Homeostasis Topic 1 Flashcards
Where is the Thyroid located/function/hormone name released
neckish part - thyroxine - regulates growth and metabolism
Where is the Hypothalamus located and what is it’s main function
It controls many parts of the body and helps in keeping the body in a stable state called homeostasis
Controls the pituitary gland and links nervous with endocrine system
Where is the Pituitary Gland and what does it do
Major endorcrine gland
Pea sized attached to the base of the brain
Important in controlling growth and development and functioning other endocrine glands.
Releases ADH hormone which regulates water balance
Releases FSH and LH which help with sperm production or menstrual cycle in females
Where is Adrenal Glands and function? (hormone released)
On top of both kidneys
Create adrenaline hormone - which increases levels of activity
Define Homeostasis
Ability to maintain a constant internal enviroment through a mechanism called the ‘negative feedback loop’
Define the negative feedack loop
A type of self regulating system that uses counter responces to correct deviations from a set condition in the internal body enviroment, ultimately to achive homeostasis.
What are the three examples of homeostasis
Temperature regulation
Blood glucose regulation
Water balance
What is the average/normal body temp
37 C
What is a deviation in temperature regulation
When there is excess heat or not enough
What is a correction in temp regulation
Heating up the body if cold and cooling if hot
What is the nergative feedback loop if body temp is too high (Cause - temp - effect)
Exposure to a hot enviroment/exersice - above 37 C - sweating, vasodilation, lowering BMR
What is the nergative feedback loop if body temp is too low (Cause - temp - effect)
Exposure to a cold enviroment - below 37 degree C - Shivering, vasocontriction, increase in BMR
What is the hypothalamus refering to temperature
Temperature sensor and monitors blood as flows through
What is BMR
Basic Metabolic Rate; general metabolism (eating light food vs hard)
What is sweating and what is its purpose
The release of moisture from the sweat glands which evaporate on the skin and cool the skin to reach a lower temperature
What is vasodilation and its purpose
It is the widening of blood vesells close to the skin to release more heat from the blood and lower body temp down to 37 C
What is the effect of decreasing BMR
Less heat is produced
What is shivering and what is its effect
Causes rapid involuntary muscle contraction (shivering) to generate heat to increases body temp
What is vasoconstriction and its effect
The narrowing of blood vessels near the skin in order to conserve heat and keep more closer to the core region like organs in order to increase temp
What is effect of increasing BMR
Increase temp
When does hypothermia occur
When body temp falls below 35C
What are effects of hypothermia
sleepy since brain temp decreases, argumentive, confused, blue tint
Later - dont feel the cold, violent shivering
30C causes death since heart stops
When does hyperthermia occur
When body temp rises above 38C - also refered to heat exhaustion
Heat stroke is when body temp rises above 40C
high temp exposure, high humidity with temp, sweating stops working
What are the effects of hyperthermia/heat stroke
Headaches, dizziness, dry red skin, nausea, profusely sweating
Define glucose
The main energry source (sugar) for cells to function
What is the normal blood glucose level per 100ml
90mg per 100ml
Blood glucose level negative feedback loop (cause - level for cause - effect by loop)
high blood glucose
If you eat and gain lots of sugar - rises above 90mg per 100ml - Insulin is released
Blood glucose level negative feedback loop (cause - level for cause - effect by loop)
low blood glucose
If you exersice or fast etc - less than 90mng per 100ml - Glycagon is stimulated by glucagon and released (stored glucose that insulin forms)
How is glucose level monitored
Hypothalamus detectes and sensores changes which then can be controlled and chnaged by the pancreas
What occurs when blood glucose levels reach over 90mg per 100ml
Insulin released into blood stream from pancreas
Insulin has 2 effects
- increases uptake of glucose from blood
- stimulates conversion of glucose in liver into glycagon
What effects does insulin have
Insulin has 2 effects
- increases uptake of glucose from blood
- stimulates conversion of glucose in liver into gltcagon
What is glycogen
stored glucose
What occurs when blood glucose levels go under 90mg per 100ml
- Stimulates conversion of glycagon into glucose through glucagon
- Releases glucose into blood stream
When do things go wrong (blood glucose level) when below 90mg per 100ml – if negative feedback loop fails - name the thing
HYPOGLYCEMIA
If they fall below 70mg - become fainting, dizzy, nausea, light headed
- easily corrected by small and frequent snacks containing carbohydrates
When do things go wrong (blood glucose level) when above 90mg per 100ml – if negative feedback loop fails - name the thing
HYPERGLYCAEMIA
- high blood sugar level (126mg or above)
- is Type 1 and 2 diabetes (further discussed)
What is TYPE 1 diabetes/hyperglycaemia
Results from inability to produce insulion - have to inject it daily
What is TYPE 2 diabetes/HYPOGLYCEMIA
Body can produce insulin but it has a weakened affect on cells - which is a result of prolonged intake of sugar
Diabetes and lifestyle relationship
80-90% diabetes linked to lifestyle (lack exersice/lots of mass in body)
Exersice can assist bringing levels down
What are they key-functions of a kidney
- Maintain water/salt balance
- Excrete urea (waste product from breaking down excess amino acids)
Where is the nephron located
Medulla (loop of henle) and outer part (cortex for the top parts) - in kidney
Where is the cortex, medulla, renal pelvis, renal artery and vein and ureter located
cortex - outer kidney ish
medulla - triangles in kdiney
renal pelvis -kidney connecting to medullas
ureter - passage to exretory system
renal vien - bottom of renal artery (left of kidney)
renal artery - above renal vein
All steps in a nephron
Blood vessel - bowmans capsule/glomerulus - proximal tubule - loop of henle - distal tubule - collecting duct
Where does ultrafiltration and reabsorption occur
Ultrafiltration - bowman’s capsule
Reabsorption - proximal tubule
Approximately how many nephrons in the kidney
1 million
What occurs in Bowman’s capsule
The glomerulus filters out all substances (except red blood cells)
What happans at proximal tubule
100% glucose/amino acids reasbsorbed back into artery
80% water/ 70% salts (depednign on how much is in body) reabsorbed too
What is ultrafiltration
The removal and filtering of substances from blood (since it isnt very selective) - filters glucose, amino acids, lots of water and salt
What is reabsorption
Replacement of substances back into blood that shouldnt be filtered out of body - occurs along enitire nephron gradually (not just proximal tubule)
How much water in urine after nephron
approx 1-2L of H2O in urine
How many L pass through nephron
Avg person filters 180L/24h yet only produces 1-2L of urine
How does homeostasis work in the kindey when water balance goes above
High intake of water - excess water level - less ADH produced (less ADH means more water away and more urine) - more urine produced
How does homeostasis work in the kindey when water balance goes below
Low intake of twater (from sweating/moisture loss through exhalation) - depleted water levels - more ADH produced - less urine produced/less water in urine