Homeostasis Flashcards

1
Q

what is homeostasis

A

the ability of living organisms to regulate it’s internal conditions, despite the changing environment

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2
Q

stimulus response model

A

Homeostasis involves a stimulus-response model in which the change in the condition of the external or internal environment is detected and appropriate responses occur via negative feedback

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3
Q

what are sensory receptors

A

sensory receptors (chemoreceptors, thermoreceptors, mechanoreceptors, photoreceptor, nociceptor) detect stimuli and can be classified by the type of stimulus

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4
Q

types of effectors

A

effectors are either muscles (which contract in response to neural stimuli) or glands ( which produce secretions)

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5
Q

what are hormones

A

hormones are chemical messengers ( produced mostly in endocrine glands) that relay messages to cells displaying specific receptors for reach hormone via the circulatory or lymphatic system

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6
Q

cells sensitivity to hormones

A

a cells sensitivity to a specific hormone is directly related to the number of receptors it displays for that hormone (an increase in receptors = upregulation, a decrease = downregulation)

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7
Q

innate immune responses in plants and animals

A

all plants and animals have innate immune responses ( general/non-specific)

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8
Q

examples of physical defence strategies of plants in response to pathogens

A

barriers and leaf structures

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9
Q

examples of chemical defence strategies of plants in response to pathogens

A

plant defensins and production of toxins

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10
Q

what is transmission of disease facilitated by

A

the transmission of disease is facilitated by regional and global movement of organisms

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10
Q

innate immune response in vertebrates

A

the innate immune response in vertebrates compromises surface barriers (skin, mucus, and cilia), inflammation and the complement system

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11
Q

Types of cellular (living) pathogens

A

o Bacteria; Leprosy
o Fungi; Athlete’s
foot (tinea)
o Protozoa;
Malaria ( genus
plasmodium)
o Parasites;
Tapeworm
(Platyhelminthes)

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12
Q

Types of acellular (non-living)

A

o Prions; CJD
o Virus; Covid-19

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13
Q

what are the Virulence factors

A

*Adherence factors: Factors that makes a pathogen stick to host cell
*Invasion factors: Components that allow bacterium to invade host cells
*Capsules: Large structure of cells that causes a polysaccharide layer that lies outside the cell envelope
Block and switch off hosts immune system
*Toxins: Poisonous substance produced within living cells or organisms
*Lifecycle change: Development changes through which an organism passes from its inception through the stage at which it reproduces

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14
Q

what is an infectious disease

A

invasion by a pathogen and can be transmitted from one host to another e.g. malaria or polio

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15
Q

what is a non-infectious disease

A

genetic and lifestyle diseases e.g. diabetes and asthma

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16
Q

what are the modes of transportation

A
  • direct contact
    -contact with bodily fluids
    -contaminated food/water
    -disease specific vectors
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17
Q

what is direct contact

A

when an infected person or organism comes in contact/touches another person therefore spreading the disease e.g kissing, shaking hands, contact with vegetation

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18
Q

what is contact with bodily fluids

A

when a pathogen spreads from blood or other bodily fluids e.g. saliva and can be transferred through the mouth, broken skin, ect

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19
Q

what is disease specific vectors

A

is when a disease is contracted through any agent who carries and transmits an infectious pathogen to another living organism e.g. Lyme disease through ticks Anthropoids are the major group of pathogen vectors ( ticks, flies ect) - many feed on blood (how pathogen enters host)

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20
Q

what is contaminated food/water

A

is when a disdeas is contracted through ingesting water/food that has been contaminated with disease causing pathgens ans is often spread through faecal route e.g. cholera, diarrhoea

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21
Q

what kind of immune system dies vertebrates have

A

vertebrates have booth innate and adaptive (specific) immune response

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22
Q
A
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23
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24
types of physical defence mechanisms (passive)
Thick barriers (e.g., bark); resistant to pathogens Leaf hairs (often containing chemicals), spines or prickles; defence against herbivores Waxy cuticles; prevents formation of moisture to inhibit bacterial infection Stoma size; small = less pathogens can enter
25
types of chemical defence mechanisms (active)
Plants produce toxic chemicals in response to pathogens (caffeine, morphine, etc.,) Some produce defensins – proteins that inhibit development of pathogens
26
what is 1st line of defence
they are physical barriers to reduce pathogen invasion
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types of 2nd line of defence
-phagocytosis -inflammatory response -fever
28
what is phagocytosis
Phagocytosis is when Phagocytic leukocytes migrate to infection sites and engulf foreign bodies to kill it " eats cells that shouldn't be there"
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what does the inflammatory response do
the inflammatory response Increases capillary permeability at infected sites, recruiting leukocytes (leads to localised swelling) to kill the pathogen/bacteria
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what happens during a fever
Increase body temp to activate heat-shock proteins and support microbial growth
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where are leukocytes (white blood cells) found
in the blood, tissue and lymphatic system
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types of leukocytes
* Neutrophils * Basophils * Eosinophils * Monocytes * Lymphocytes (3rd line of defence)
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describe neutrophils leukocytes
-most abundant type -first responder to infection -Die after phagocytosing a few pathogens
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describe Basophils leukocytes
o Circulate in bloodstream o Responsible for initiating inflammatory responses by releasing chemicals (histamine)
36
describe Eosinophils leukocytes
o Prominent at sites of allergic reaction and parasite infections o Rare in blood, common at mucous membranes
37
describe monocytes leukocytes
o Share phagocytosis with neutrophils o Longer lasting o Differentiate into two types of cells Macrophages (phagocytose) Dendrite cells
38
describe Lymphocytes leukocytes
o Responsible for production of antibodies Antibodies; target specific antigens on pathogens o Include B and T cells o Involved in destruction of virus-infected body-cells o Slowest to respond (require antigen presentation)
39
what is the inflammatory response
* The way the body reacts when pathogens damage cells * Damaged cells release prostaglandins (chemical that directs blood flow to an injured area) which work like histamine (causes vasodilation to recruit leukocytes to area) * Damaged cells also release chemokines that recruit phagocytes to site of damage to fight infection
40
what is the complement system
* Works in conjunction with innate immune system * Where your body produces proteins that can trigger phagocytosis (usually from liver)
41
what is Acquired (adaptive immunity)
*Responds to specific antigens by creating antibodies and memory cells *Relies on the clonal expansion of plasma cells to produce large numbers of antibodies thus there is a delay between initial exposure to pathogen and production of large quantities of antibodies *Distinguishes self-cells from antigens via lymphocytes that enter the blood from the bone marrow or thymus and become either T lymphocytes (thymus) or B lymphocytes (bone marrow)
42
what is the Humoral Immune Response
*From serum antibodies (produced by plasma cells) *Refers to bodily fluids where free-floating serum antibodies bind to antigens and assist in elimination *When they encounter pathogen, produce antibodies that complimentarily fit antigen *B-cells divide rapidly to produce cells with replicates of the antibodies or cells that remain long after in case of reinfection (memory cells)
43
what is the Cell-mediated immune response
*Response carried out by T-cells *Helper T-cells activate other immune cells *Cytotoxic T-cells assist with elimination of pathogens and infected host cells
44
what are T-cells
1. Attract and activate phagocytes 2. Localise pathogen to prevent locomotion 3. Rupture pathogen membrane and destroy it 4. Can also become memory cells
45
Passive Vs active immunity
Active: - The production of antibodies by the body itself - Longer-lasting *Creates memory cells Types of active - NATURAL; infection -ARTIFICIAL; vaccination Passive: -The acquisition of antibodies from another source -short-lived *No memory cells developed Types of passive NATURAL; maternal antibodies ARTIFICIAL; monoclonal antibodies
46
what are FACTORS THAT AFFECT IMMUNITY
*Persistence of pathogens within host *Transmission mechanism *Proportion of the population that is immune/has be immunised *Mobility of individuals in the affected population
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48
what is metabolism
*chemical reactions occurring in the cells = metabolism o these metabolic processes process in small steps, the sum of which is called a metabolic pathway o all the anabolic and catabolic reactions happening in an organisms metabolism as a whole  CATABOLIC REACTIONS BREAK DOWN (e.g., C6H12O6(glucose) to CO2 and H2O)  ANABOLIC REACTIONS BUILD COMPLEX MOLECULES (E.G., from H2O and CO2 to C6H12O6(glucose) in photosynthesis) - Require energy
49
what are optimal conditions
-Each step of metabolic pathways requires a specific enzyme (THE 5 FACTORS THAT AFFECT ENZYME ACTIVITY)
50
what is Tolerance limit
-The range of particular environment (eg. light, temperature, availability of water) or physiological (particular chemical concentrations) factor within which an organism can survive.
51
what is the negative feedback loop
o Causes a response that brings the body back to normal E.g., FEVER: High temp detected by sensors Relayed to temp-regulatory control centre in brain Control centre processes info and activates effectors (e.g., sweat glands)
52
what is postive feedback loop
o Involves an increase in function away from normal E.g., CHILDBIRTH:  Head presses on cervix Pressure activates a signal Oxytocin gets released from pituitary gland Oxytocin increases contractions
53
what are sensory receptors
Structures that detect changes in the external of internal environment
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steps of Stimulus model
Input -> receptor ->regulator -> effector ->output
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types of sensory receptors
*NOCICEPTOR o Responds to damaging or potentially damaging stimuli by sending signals to spinal cord and brain *THERMORECEPTOR o Detects differences in temp *CHEMORECEPTOR o Detects chemical composition of blood levels (CO2, O2, ion conc.) *MECHANOCEPTOR o Detect touch, pressure, vibration and sound from ex. And int. environments *PHOTORECEPTOR o Detects changes in light (RETINA)
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what is a stimulus
: a detectable change in internal or external environment (INPUT). Can be physical or chemical
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process of stimulus model
*sensory RECEPTORs detect the stimuli *A chemical message is then transmitted to the coordinating centre (REGULATOR) that determines if a change is required *Another chemical messenger brings about a response (OUTPUT) within a cell or EFFECTOR organ
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types of neurons
*Sensory neurons: o Convert external stimuli from organism’s environment into internal electrical impulses *Motor neurons: o Form the pathway which impulses pass from brain/spinal cord to effectors
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how nerve implus occur in ACTIVE TRANSPORT/DIFFUSION/SELECTIVE PERMEABILITY OF CELL MEMBRANE
* ACTION POTENTIAL (when nerve impulse passes through) o Occurs when resting potential across membrane has high stimulis (ex. Mechanical) o AXON becomes depolarised (inside becomes less negative) o 35mV o Then returns to resting potential (REPOLARISATION)
60
what are nerve impulses
* Neurons convey info via nerve impulses (electrical signal) * RESTING POTENTIAL o When a nerve is not sending a nerve impulse it has a resting potential of -70mV  Inside of neuron is negative relative to outside  INSIDE; lots of large negative ions  OUTSIDE; lots of Na, Cl and Ca ions
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how does action potential occur
* VOLTAGE-gated ion channels (closed during resting potential) open allowing sodium ions to move in (makes inside more positive) AT PEAK OF ACTION POTENTIAL; Na channels close K channels open  K leaves  inside becomes negative again
62
transmission of nerve impulse
* Impulse forms because action potential causes a small current to flow in cytoplasm and in extracellular fluid which stimulates depolarisation of the next part of the nerve membrane
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what are synapses
* The junction between a neuron and another neuron or effector by passage of a nerve impulse or of a chemical called a neurotransmitter
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what is signal transduction
* the conversion of chemical signals that are transmitted from outside the cell to a functional change or response within the cell
65
hydrophilic signals
Received by receptors on cell membrane 1. signal molecules binds to specific receptors outside of cell membrane. When combined the receptor changes shape or activates an internal response 2. activation inside the cell causes a signal transduction cascade creating effector protein 3. the resulting effector protein results in * changes to cellular metabolism/function/movement * gene expression change 4. sometimes there is no transduction cascade and the effector protein is produced from the change in receptor shape 5. receptor can be ‘reset’ and release the signal molecule
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thermoregulation
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ENDOTHERM
animal that produces it's own heat
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STRUCTURAL FEATURES
* Brown Adipose Tissue o Specialised for rapid heat production o Stores lipids (lots of energy) o Contains more mitochondria than white fat o Provides insulation o Skin, feathers, fur and blubber provide insulation  Reduce heat flow between animals and environment
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BEHAVIOURAL RESPONSES
* Kleptothermy o The sharing of heat amongst animals * Hibernation o Prolonged, usually seasonal state (colder months) of reduced activity and metabolic depression o Body temp drops o Reduced energy expenditure o Can also delay reproduction * Torpor o Reduction of metabolic activity daily (or usually nightly) o Period of torpor depends on air temp (colder means greater days in torpor) * Aestivation o Form of hibernation/torpor that occurs during warmer months o Usually in response to a lack of food in arid environments
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PHYSIOLOGICAL MECHANISMS
* Construction of the capillaries restricts blood flow in the skin, lowering heat loss * Vasodilation allows blood to flow through the skin capillaries and transport heat from the body to the skin facilitating heat loss
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EVAPORATIVE HEAT LOSS
* Panting increases the cooling effects in birds and many mammals * Sweating moistens the skin, helping to cool an animal down
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what is COUNTERCURRENT HEAT EXCHANGE
* The arrangement of blood vessels in many marine animals and birds allows for counter current heat exchange * Transfer of heat between fluids flowing in opposite direction and reduce heat loss
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HOMEOSTATIC MECHANISMS rolw
The hypothalamus has a central role in thermoregulation – it registers core body temp and coordinates nervous and hormonal responses to restore normal body temps
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insulin role
* Insulin signals cells to take up glucose from the blood -> increasing metabolic activity
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what is osmoregulation
Osmoregulation is the process of maintaining salt and water balance (osmotic balance) across membranes within the body.
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nephron role
* Filters blood * Reabsorbs nutrients * Secretes excess waste molecules * Water is absorbed from o Collecting duct o Distal convoluted tubule
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WHAT CONTROLS THE BODY’S REABSORPTION OF WATER?
* Anti-diuretic hormone (ADH) o Produced in hypothalamus o Increases permeability of the distal convoluted tubules and collecting ducts to water o This results in more water being reabsorbed from the glomerular filtrate back into the blood o Thus less concentrated urine is excreted o Restores normal water balance (negative feedback loop)
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what happens in opposite of ADH
if osmoreceptors detect higher water content -> less ADH released -> decreases permeability and so forth
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what triggers anti-diuretic hormones
* High blood concentration * Low blood volume * Low blood pressure
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what are Osmoconformers
o Cannot regulate o Match their body’s salt levels/osmolarity of body fluids to their environment o Make substances to keep external and internal molarity equal o No energy used e.g. some marine animals
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what are osmoregulators
2) OSMOREGULATORS o Actively control internal salt and water balance/keeps osmolarity of body fluids constant o Need to be able to get rid of excess salts or actively promote uptake of salts from environment o Use energy to maintain the osmatic gradients via active transport (e.g., most land animals & fish)
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Hydrophyte
- Any plant adapted to grow wholly or partly submerged in water or wet habitats
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Mesophyte
o A plant adapted to growing in well-watered soil.
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* XEROPHYTE
o A plant that has adaptations to survive in an environment with little liquid water.
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* HALOPHYTE
o A plant that grown in waters of high salinity.
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stomata
o Openings on the underside of leaves o When the plant has enough water, stomata open. Oxygen and water vapor can exit. o When plant is low on water stomata to close. This reduces water loss through transpiration, helping the plant conserve water and maintain its internal balance.
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* VACUOLES
o Vacuoles regulate the turgidity by regulating the amount of water present inside the cell. o cell has excessive water: vacuole usually absorbs the water and then diffuses it out of the cell o cell lacks water: water from the vacuole tends to revert into the cell thereby maintaining turgidity
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* CUTICLE
o prevents evaporation of water from the epidermal surface (DRY/HOT ENVIRONMENT) o can also prevents external water and solutes from entering the tissues (WET/HUMID ENVIRONMENT)
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