homeostasis Flashcards
describe how ultrafiltration occurs
hydrostatic pressure
small molecules (glucose, ions) and liquids (water) pass through capillary endothelium
- through basement membrane
- into renal capsule
where does ultrafiltration occur
glomerulus
what does homeostasis mean
involves physiological control systems that maintain the internal environment within restricted limits
what is homeostasis important for
- maintaining core body temperature
- maintaining blood pH in relation to enzyme activity
what does negative feedback mean
any deviation from normal value, there are mechanisms put in place to bring conditions back to original level
what detects changes in blood glucose levels
pancreas - beta cells (when levels are high) and alpha cells (when levels are low) in islets of Langerhans
- ISLETS OF LANGERHAN release insulin/glucagon to bring glucose levels to normal
when is insulin released
BGL to high
when is glucagon released
BGCtoo low
when is adrenaline released
when body anticipates danger
= more glucose released from hydrolysis of glycogen in liver
what happens after insulin is released
liver cells become more permeable to glucose
- enzymes activated to convert glucose to glycogen
- glucose removed from blood and stored as glycogen in cells
- normal BGC
what occurs after glucagon and adrenaline are released
second messanger model occurs to activate enzymes to hydrolyse glycogen into glucose
- glucose released back into blood
- BGC normal
what is the role of insulin in lowering BGC
- attaches to receptors on surfaces of target cells (liver/muscle) which changes tertiary structure of channel proteins in cell membrane = more glucose absorbed (facilitated diffusion)
- more protein carriers incorporated into cell membranes so that more glucose is absorbed from blood into cells
- activates enzymes to convert glucose into glycogen (glycogenesis)
what is the action of glucagon which increases BGC
- attaches to receptors on target cells (liver/muscle)
- causes protein to be activated into adenylate cyclase
- ATP converts to cAMP
- cAMP activates protein kinase (hydrolyses glycogen into glucose)
- activates other enzymes to convert glycerol from lipids and AA from proteins into glucose
explain the second messenger model
- glucagon binds to receptors on cell membrane
- changes shape to adenylate cyclase
- adenylate cyclase activates the conversion of ATP to cAMP (second messenger)
- cAMP activates protein kinase which converts glycogen into glucose
what is gluconeogenesis and where does this occur
creating glucose from other molecules (amino acids and glycerol in liver)
occurs in liver due to enzymes found there
what is glycogenesis and where does it occur
converting glucose into glycogen
occurs in the liver and catalysed by enzymes there