Hogkin-Huxley Model 1&2 Flashcards
In long cellular processes e.g. dendrites, how does passive response change with distance from stimulus?
it decreases exponentially
what is the equation for the change in potential along dendrites?
define the terms of this equation
∆Vm = ∆Vmax * e^(-x/λ)
∆Vm- change in membrane potential
∆Vmax - the potential where input is injected (the highest potential)
x- the distance we measure from
λ- the length constant (the rate a which decay happens- calculated by working out the time to decrease to 37%)
What are the 3 components of resistance?
Rm, Ra and Rext
what is Ra?
how the dendrite resists down its axial length
what’s Rext?
the external resistivity of external medium (ECM)
What’s Rm?
the relationship between Rext and Ra
What happens if Rm is high?
there’s less current flowing out (less leaky), so the voltage will decay slower in space, hence travel further
define electrotonic conduction
the passive spread of voltage along a membrane
what property does lambda represent?
conductance
what 2 physiological conditions (linked to resistance) gives greatest conductance?
1) if Rm is high- there’s low ion channel density/high insulation (myelination) so the membrane is not very leaky- increases conductance
2) if Ra is low- the diameter of membrane process is high, thick dendrites so reduced resistance- better conductance
how is membrane potential calculated?
Vm= Vin - Vout
what is reversal potential
change in direction of net current as Vm swings around Es
what is driving force calculation?
Es- Vm
what is membrane current calculation?
Is-gs (Es-Vm)
what are the strengths of the RC-based leaky integrate and fire model
we have good biological understanding, it’s simple, has an exponential solution