Hodgkins Lymphoma Flashcards
Explain the bimodal incidence seen in Hodgkin’s lymphoma
First peak (20-29 years of age )
Second peak at age -60
>90 of cases happens between 16-65 years of age
Histologically what does Reed stern berg cell stand for
It is a diagnostic marker for Hodgkin’s lymphoma
Reed stern berg cell has what effect
Owl eye effect
Is classical reed stern berg cell part of the majority or minority
It is part of the minority admits reactive inflammatory cells
Describe classical reed stern berg cell
Reed stern berg cell is a very large cell that has two nucleus and an eosinophilic nucleus with an area of clearing
Describe the mononuclear form of reed stern berg cell
It has the same morphological features of reed stern berg cell except that it only has one nucleus
List the variants of reed stern berg cell
Lacunar cells
L&H(lymphocytic and histiocytic)also known as popcorn cells
Pleomorphic cells
WHO classification of Hodgkin’s lymphoma
1.Classical Hodgkin’s lymphoma
2.nodular lymphocytic -predominant (NLPHL)
In classical Hodgkin’s lymphoma what cells do you find there
it contains mononuclear variant /binucleate and multinucleate cells
List the 4 histological subtypes in classical Hodgkin’s lymphoma
1.nodular sclerosing :(Lacunar cells)
2.multi cellularity (it has both classical RS and mixed inflammatory cells)
3.lymphocyte rich classical
4.lymphocyte depleted ;poor prognosis
Nodular lymphocyte -predominant Hodgkin’s lymphoma (NLPHL)
It contains both (L &H)(lymphocytic and histiocytic )cells
What are the positive immunophenotypes in classical Hodgkin’s lymphoma
CD30+
CD15+
What are the positive immunophenotypes in classical Hodgkin’s lymphoma
CD30+
CD15+
What are the negative immunophenotyoes of classical Hodgkin’s lymphoma
CD20-
CD3-
CD45-
CD75-
CD79a-
Mention the positive immunophenotypes of Nodular lymphocytic -predominant Hodgkin’s lymphoma
CD45+
CD75+
CD79+a
CD20+
