Hodgkin Lymphoma - Krafts

Question 1

What is the characteristic cell in Hodgkin Lympoma?

Answer 1

Reed-Sternberg (R-S) cell

• very very large cell
• two or more nuclei
• surrounding, clear “halos,” big nucleoli
  
  • as big as the adjacent normal lymphocytes
• abundant cytoplasm

Question 2

What characterizes Hodgkin Lympoma?

Answer 2

• Younger patients, good prognosis
  
  • 20s
• Contiguous (predictable) spread
  
  • lymph node → continues through same lymph node chain
• Five subtypes
• Reed-Sternberg cell

Question 3

What characterizes Nodular Lymphocyte-Predominance Hodgkin Lymphoma?

Answer 3

• Asymptomatic young male with cervical lymphadenopathy
• Good prognosis (early stage)
• B-cell origin
• Popcorn cells
  
  • don’t really look like Reed-Sternberg cells

Question 4

What characterizes Nodular Sclerosis Hodgkin Lymphoma?

Answer 4

• Most common subtype
• Good prognosis (early stage)
• Lacunar cells
  
  • not typical Reed-Sternberg cells
  • cytoplasm retracts

Question 5

What are the cell morphologies in Nodular Sclerosis Hodgkin Lymphoma?

Answer 5

• lacunar cell
  
  • cell with single, hyperlobated nucleus and abundant, pale-staining cytoplasm
  • formalin fixation makes the cytoplasm retract, and the cell appears to be sitting in a little space, or lacuna
• Collagen bands divide lymph node tissue into nodules (hence, “nodular sclerosis”).

Question 6

What characterizes Mixed Cellularity Hodgkin Lymphoma?

Answer 6

• Worse prognosis
• Usually disseminated at presentation
• Classic Reed-Sternberg cells
• Mixture of background cells

Question 7

What characterizes Lymphocyte-Rich Hodgkin Lymphoma?

Answer 7

• Uncommon
• Usually localized at presentation
• Popcorn cell

Question 8

What characterizes Lymphocyte Depletion Hodgkin Lymphoma?

Answer 8

• Rare
• Often disseminated at presentation
• Classic Reed-Sternberg cells
• Collage or reticulin background

Question 9

What is the treatment for Hodgkin Lymphoma?

Answer 9

• Surgery
• Chemotherapy
  
  • danger of second malignancies
    
    • more difficult to treat
    • hematopoietic, breast/skin cancer
• Radiation

Question 10

What is the prognosis of Hodgkin Lymphoma?

Answer 10

• Depends on stage
• Danger: second malignancies