HMP shunt Flashcards
1
Q
In what tissues does the HMP shunt occur?
A
liver
RBCs
lactating mammary glands
adrenal cortex
2
Q
What is the most important product of the HMP shunt?
A
NADPH
3
Q
What use does NADPH have?
A
- reduces oxidative stress in RBCs
- required for cholesterol and fatty acid synthesis
4
Q
Which enzymes require NADPH?
A
glutathione reductase
HMG-CoA reductase
5
Q
What is the RL step of HMP shunt?
A
glucose-6-phosphate dehydrogenase
6
Q
What enzyme in the HMP shunt requires B1?
A
transketolases
