HLAs & Abs

Question 1

HLA B5

Answer 1

Bechet - uveitis, genitical ulceres, apthous ulcer
PCKD
UC

Question 2

HLA DQ2

Answer 2

Coeliacs - dermatitis herpetiformis

Question 3

HLA D3

Answer 3

Addisons disease
Grave’s disease
Sjogren

Question 4

Role of HLAs

Answer 4

Interact with CD8 positive T cells
involved in cytotoxic reactions

Question 5

C1 deficiency

Answer 5

SLE
RA
(also C2 and C4)

Question 6

C2 deficiency

Answer 6

SLE
RA
Recurrent URTI with streptococcus pneumoniae

Question 7

C3 deficiency

Answer 7

RARE:
recurrent infection with encapsulated bacteria: haemophilus, S. pneumonia, Neisseria meningtides, salmoella typhi

Question 8

C4 deficiency

Answer 8

SLE
RA
heriditory angioedema
unchecked activation of C1 leads to consumption of C4

Question 9

C5 deficiency

Answer 9

opportunistic infection: menigoccous and gonnorhoea
C5 activates the C5-C9 pathway which leads to membrane attack complex - no cell lysis without

Question 10

HLA DQ2/HLA DQ8

Answer 10

coeliac

Question 11

HLA DR3/ HLA DQ4

Answer 11

T1 diabetes

Question 12

anti-rho/anti la

Answer 12

SLE (CONGENITAL SLLE)
Sjogrens

Question 13

ANA

Answer 13

SLE
sjogrens
oligoarticular JIA

Question 14

Anti-Jo1

Answer 14

myositis specific - idiopathic inflammatory myopathies

Question 15

anti ds DNA

Answer 15

SLE

Question 16

anti-smooth muscle

Answer 16

AI hepatitis

Question 17

rheumatoid factor

Answer 17

polyarticular JIA

Question 18

HLA b27

Answer 18

ankylosing spodylitis

Question 19

pANCA

Answer 19

wegners granulomatosis

Question 20

cANCA

Question 21

HLA - B47

Answer 21

21 hydroxylase deficiency

Question 22

HLA CW6

Answer 22

psoriasis

Question 23

HLA DR2

Answer 23

MS
SLE