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Rheumatology > HLA associations > Flashcards

HLA associations Flashcards

1
Q

Which Chromosome are the genes for HLA chromosomes encoded

A

Chromosome 6

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2
Q

Class I HLA antigens

A

HLA A, B and C are class I antigens

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3
Q

Class II HLA antigens

A

DP, DQ, DR are class II antigens

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4
Q

HLA- A3

A

Haemochromatosis

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5
Q

HLA-B51

A

Behcet’s

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6
Q

HLA-B27

A

ankylosing spondylitis
Reiter’s syndrome
acute anterior uveitis

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7
Q

HLA-DQ2/DQ8

A

Coeliac disease

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8
Q

HLA-DR2

A

Narcolepsy

Goodpasture’s

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9
Q

HLA-DR3

A

dermatitis herpetiformis
Sjogren’s syndrome
primary biliary cirrhosis

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10
Q

HLA-DR4

A

type 1 diabetes mellitus*

rheumatoid arthritis - in particular the DRB1 gene (DRB104:01 and DRB104:04 hence the association with DR4)

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11
Q

What is hydroxychloroquine used for

A

Mangement of Rheumatoid arthritis and systemic/discoid lupus

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12
Q

Adverse effects of Hydroxychloroquine

A

Bull’s eye retinopathy -severe and permanent visual loss

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13
Q

Interferons- what are they?

A

Cytokines released by the body in response to viral infections and neoplasia

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14
Q

Interferon alpha features

A

produced by leucocytes
antiviral action
useful in hepatitis B & C, Kaposi’s sarcoma, metastatic renal cell cancer, hairy cell leukaemia
adverse effects include flu-like symptoms and depression

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15
Q

Interferon beta features

A

produced by fibroblasts
antiviral action
reduces the frequency of exacerbations in patients with relapsing-remitting MS

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16
Q

Interferon gamma features

A

predominately natural killer cells. Also by T helper cells
weaker antiviral action, more of a role in immunomodulation particularly macrophage activation
may be useful in chronic granulomatous disease and osteopetrosis

17
Q

Antibodies in diffuse cutaneous systemic sclerosis

A

anti-scl 70

18
Q

Antibodies in limited cutaneous systemic sclerosis

A

Anti-centromere antibodies

Rheumatology (11 decks)

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