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Pathology > HLA and Autoantibodies > Flashcards

HLA and Autoantibodies Flashcards

1
Q

Ankylosing Spondylitis

A

HLA B27

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2
Q

Goodpasture’s Syndrome

A

HLA DR15

HLA DR2

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3
Q

Graves Disease

A

HLA DR3

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4
Q

SLE

A

HLA DR3
PTPN22
CTLA4

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5
Q

T1DM

A 
HLA DR3
HLA DR4
PTPN22
PTPN22
CTLA4
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6
Q

RA

A

HLA DR4

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7
Q

Anti Phospholipid Syndrome

“Hugh’s syndrome”

A

Cardiolipin

Lupus antigcoagulant

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8
Q

Autoimmune hepatitis

A

Anti-smooth muscle
Anti-LKM-1
Anti-SLA

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9
Q

Autoimmune Haemolytic Anaemia

A

Anti-Rh

Blood group antigen

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10
Q

ITP

A

Anti-glycoprotein IIb-IIIa

Ib-IX Antibody

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11
Q

Churg Strauss Syndrome

A

p-ANCA

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12
Q

Coeliac Disease

A

Anti-tissue transglutaminase antibody

Anti-endomysial antibody

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13
Q

Congenital heart block in infants of mothers with SLE

A

Anti-Ro

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14
Q

Dermatitis herpetiformis

A

Anti-endomysial antibody

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15
Q

Dermatomyositis

A

Anti-Jo1

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16
Q

Diffuse Cutaneous Scleroderma

A

Antibodies to topoisomerase/Scl70
RNA polymerase I,II,III
Fibrillarin

17
Q

Goodpasture’s Syndrome

A

Anti-GBM

18
Q

Graves Disease

A

Anti-TSH receptor

19
Q

Hashimoto’s Thyroiditis

A

Antibodies to thyroglobulin

thyroperoxidase

20
Q

CREST

A

Anti-centromere

21
Q

Microscopic Polyangitis

A

p-ANCA

22
Q

Mixed connective tissue disease

A

Anti-U1RNP

23
Q

Myasthenia Gravis

A

Anti-Ach

24
Q

Pernicious anaemia

A

Antibody to gastric parietal cells

Antibody to IF

25
Q

Polymyositis

A

Anti-Jo1

26
Q

Primary biliary cirrhosis

A

Anti-mitochondrial

27
Q

RA

A

Anti-CCP

RF

28
Q

Sjogren’s Syndrome

A

Anti-Ro

Anti-La

29
Q

SLE

A 
Anti-dsDNA
Anti-Ro
Anti-La
Anti-Sm
Anti-U1RNP
30
Q

T1DM

A

Antibodies to glumate decarboxylase

Antibodies to pancreatic B Cells

31
Q

Wegener’s Granulomatosis

A

c-ANCA

Pathology (7 decks)

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