HLA and Autoantibodies

Question 1

Ankylosing Spondylitis

Answer 1

HLA B27

Question 2

Goodpasture’s Syndrome

Answer 2

HLA DR15

HLA DR2

Question 3

Graves Disease

Answer 3

HLA DR3

Question 4

SLE

Answer 4

HLA DR3
PTPN22
CTLA4

Question 5

T1DM

Answer 5

HLA DR3
HLA DR4
PTPN22
PTPN22
CTLA4

Question 6

RA

Answer 6

HLA DR4

Question 7

Anti Phospholipid Syndrome

“Hugh’s syndrome”

Answer 7

Cardiolipin

Lupus antigcoagulant

Question 8

Autoimmune hepatitis

Answer 8

Anti-smooth muscle
Anti-LKM-1
Anti-SLA

Question 9

Autoimmune Haemolytic Anaemia

Answer 9

Anti-Rh

Blood group antigen

Question 10

ITP

Answer 10

Anti-glycoprotein IIb-IIIa

Ib-IX Antibody

Question 11

Churg Strauss Syndrome

Answer 11

p-ANCA

Question 12

Coeliac Disease

Answer 12

Anti-tissue transglutaminase antibody

Anti-endomysial antibody

Question 13

Congenital heart block in infants of mothers with SLE

Answer 13

Anti-Ro

Question 14

Dermatitis herpetiformis

Answer 14

Anti-endomysial antibody

Question 15

Dermatomyositis

Answer 15

Anti-Jo1

Question 16

Diffuse Cutaneous Scleroderma

Answer 16

Antibodies to topoisomerase/Scl70
RNA polymerase I,II,III
Fibrillarin

Question 17

Goodpasture’s Syndrome

Answer 17

Anti-GBM

Question 18

Graves Disease

Answer 18

Anti-TSH receptor

Question 19

Hashimoto’s Thyroiditis

Answer 19

Antibodies to thyroglobulin

thyroperoxidase

Question 20

CREST

Answer 20

Anti-centromere

Question 21

Microscopic Polyangitis

Answer 21

p-ANCA

Question 22

Mixed connective tissue disease

Answer 22

Anti-U1RNP

Question 23

Myasthenia Gravis

Answer 23

Anti-Ach

Question 24

Pernicious anaemia

Answer 24

Antibody to gastric parietal cells

Antibody to IF

Question 25

Polymyositis

Answer 25

Anti-Jo1

Question 26

Primary biliary cirrhosis

Answer 26

Anti-mitochondrial

Question 27

RA

Answer 27

Anti-CCP | RF

Question 28

Sjogren's Syndrome

Answer 28

Anti-Ro | Anti-La

Question 29

SLE

Answer 29

``` Anti-dsDNA Anti-Ro Anti-La Anti-Sm Anti-U1RNP ```

Question 30

T1DM

Answer 30

Antibodies to glumate decarboxylase | Antibodies to pancreatic B Cells

Question 31

Wegener's Granulomatosis

Answer 31

c-ANCA