HLA Flashcards

1
Q

A3

A

Hemochromatosis

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2
Q

B27

A

PAIR:

Psoriasis, Ankylosing Spondylitis, IBD, Reiter’s syndrome

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3
Q

DQ2/DQ8

A

Celiac disease

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4
Q

DR2

A

MS, hay fever, SLE, Goodpasture’s

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5
Q

DR3

A

DM 1, Grave’s disease

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6
Q

DR4

A

Rheumatoid Arthritis, DM 1

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7
Q

DR5

A

Pernicious anemia -> B12 deficiency, Hashimoto thyroiditis

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8
Q

MHC I

A
HLA-A, HLA-B, HLA-C
binds TCR & CD8
on ALL nucleated cells (not RBCs)
Ag loaded in RER
mediates viral immunity
B2-microglobulin
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9
Q

MHC II

A

HLA-DR, HLA-DP, HLA-DQ
binds TCR & CD4
only on APCs

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