HLA Flashcards
1
Q
which chromosome/arm is the HLA MHC complex located?
A
the p arm (short arm) of chromosome 6
2
Q
what are the components of MHC class 1 and class 2?
A
class 1 - one polymorphic chain and beta-2-microglobulin
class 2 - two polymorphic chains
3
Q
what are the HLA associated with Coeliac disease?
A
HLA-DQ2 = 90% HLA-DQ8 = 2-10%
however, many false positive
useful as a rule-out, but not rule-in test
4
Q
what population would you HLA type when starting? And what is the HLA
- carbamazepine
- abacivir
A
- Han Chinese in Taiwan - HLA-B1502, HLA-B3101
2. white populations - HLA-B*5701
5
Q
Which HLA is the highest risk for DM?
A
the highest seems to be DR3/DR4.
not sure about the background to this, but it came up in lecture
