HL1: Emergencies and Resuscitation Flashcards
Normal UO (infants, young children)
1.5-2 mL/kg/hr
Normal UO (older children)
1 mL/kg/hr
Hypotension (<1mo)
SBP<60
Hypotension (1mo-1yr)
SBP<70
Hypotension (>1yr)
SBP< 70 + (2 x age)
Target end tidal CO2 during CPR
> 20mmHg
Shockable arrest rhythms (2)
Vfib and pulseless Vtach
Defibrillation doses
Initial shock: 2 J/kg
Second shock: 4 J/kg
Indication for emergent cardioversion
Hemodynamically unstable patients with tachyarrythmias and palpable pulses
Cardioversion doses
Initial shock: 0.5-1 J/kg
Second shock: 2 J/kg
Emergency meds you can administer via ETT
NAVEL: naloxone, atropine, vasopressin, epinephrine, lidocaine
Target RR during resuscitation
20-30 bpm (1 breath every 2-3 sec)
Sellick maneuver
The use of cricoid pressure to minimize gastric reflux and aspiration
How long should preoxygenate prior to endotracheal intubation?
At least 3 minutes
What should set suction devide to during ET intubation?
-80 to -120 mmHg
ETT size equation
ETT size = (age/4) + 4
ETT depth equation
ETT depth (cm) = ETT size x 3
4 common cuases for ET inbubation failure
DOPE: Displacement, Obstruction, Pneumothorax, Equipment failure
Adenosine indication & mechanism (in resuscitation)
SVT 2/2 AV node reentry or accesory pathways
Blocks AV node conduction
Adenosine dosing (in resuscitation)
Initial: 0.1 mg/kg (IV), max 6mg wait 2min between doses
2nd: 0.2 mg/kg (IV), max 12mg
3rd: 0.3 mg/kg (IV), max 12 mg
Adenosine side effects (in resuscitation)
Sense of doom, brief period of asystole
Amiodarone indication and mechanism (in resuscitation)
Shock-refractory VF, VT or SVT
K channel blocker, prolongs QT and QRS
Amiodarone dosing (in resuscitation)
5 mg/kg (IV/IO), max 300mg
Amiodarone side effects (in resuscitation)
Polymorphic VT, hypotension, decreased cardiac contractility
Atropine indication and mechanism (in resuscitation)
Bradycardia (esp in rapid sequence intubation where also decreases oral secretions), cholinergic drug toxicity, 2nd/3rd degree AV block
Anticholinergic increases AV node conduction
Atropine dose (in resuscitation)
0.2 mg/kg (IV/IM/IO), min 0.1 mg/dose, max 0.5 mg/dose. repeat once every 5min Max total 1mg (child) or 3mg (adolescent).
Atropine dose (rapid sequence intubation)
0.4-0.6 mg/kg
Atropine side effects
Tachycardia, myocardial ischemia, paradoxical bradycardia with too low dosing
Calcium chloride indication
Hypocalcemia, hyperkalemia, CCB overdose
Calcium chloride dose
20 mg/kg (IV/IO), max 1g
Calcium chloride side effects
Risk of myocardial necrosis, peripheral infoltration leading to tissue injury
Dextrose (in resuscitation) dose
0.5-1 g/kg (IV/IO).
Newborn: 5-10 mL/kg D10W
Infant/child: 2-4 mL/kg D25W
Adolescents: 1-2 mL/kg D50W
Epinephrine indication and mechanism (in resuscitation)
Asytole, PEA, VF, VT (give within 5 minutes). Diastolic hypotension, bradycardia.
Alpha agonism
Epinephrine dosing (in resuscitation)
0.01 mg/kg (IV/IO), max 1mg
Or, 0.1 mg/kg (ET), max 2.5 mg
repeat every 3-5 min
Epinephrine side effects
Tachycardia, ectopy, tachyarrythmias, hypotension
Lidocaine indication and mechanism (in resuscitation)
Shock-refractory VF, VT (second line after amiodarone). Used in ET intubation to prevent increase in ICP. Can use on status asthmaticus.
Na-channel blocker
Lidocaine dosing (in resuscitation)
1 mg/kg (IV/IO), max 100mg
Or, 2-3 mg/kg (ET)
repeat every 5 minutes Max 3 mg/kg in the first hour
Lidocaine side effects (in resuscitation)
Myocardial depression, AMS, seizures, muscle twitching
Mag sulfate indication and mechanism (in resuscitation)
Torsades, hypomagnesemia
Calcium antagonist decreases abnormal depolarizations
Mag sulfate dose (in resuscitation)
50 mg/kg (IV/IO), max 2g
Mag sulfate side effect
Hypotension, bradycardia
Naloxone dose (in resuscitation)
0.1 mg/kg (IV/IO/subQ/IM), max 2g
Or, 0.2-1 mg/kg (ET)
Or, 2-8 mg (IN)
redose every 2 min prn
Procainamide indication and mechanism (in resuscitation)
Refractory SVT, afib, aflutter, VT
Na-channel blocker
Procainamide dose (in resuscitation)
Load 15-20 mg/kg (IV/IO) and infuse over 30-60 minutes
Procainamide side effects
Proarrythmic, polymorphic VT, hypotension
Glycopyrrolate indication
Prevents hypersalivation and bradycardia in ET intubation, and preserves pupillary exam iso trauma (compared with atropine)
Glycopyrrolate dose (in ET intubation)
0.004-0.01 mg/kg (IV/IO/IM), max 0.1 mg
Etomidate (induction agent sedative) pros and cons
Pros: minimal CV side effects, can minimally decrease ICP
Cons: supresses adrenal corticosteroid synthesis, lowers seizure threshold, avoid in septic shock
Fentanyl (induction agent analgesic sedative) pros and cons
Pro: minimal CV effects, good in shock
Con: chest wall rigidity, bradycardia, respiratory depression
Ketamine (induction agent analgesic sedative) pros and cons
Pros: bronchodilation, abates bradycardia, increases HR and SVR, dissociative amnesia
Cons: hallucinations, hypersalivation, vomiting, laryngospasm
Midozolam (induction agent amnestic anxiolytic sedative) pros and cons
Pro: miniman CV effects
Cons: resp depression, hypotension
Propofol (induction agent sedative) Pros and cons
Pro: ultra short acting
Cons: myocardial depression, metabolic acidosis, paradoximal hypertension in children, avoid in shock
Succinylcholine (induction agent, depolarizing neuromuscular blockade) proc and cons
Pros: rapid onset, short acting, reversible with acetylcholinesterase inhibitor
Cons: hyperkalemia, increased ICP, intraocular and intragastric pressure, bradycardia, malignant hyperthemia
Succinylcholine (induction agent, depolarizing neuromuscular blockade) contraindications
NM disease, myopathies, spinal cord injuries, crush injury, burns, renal insufficiency
Rocuronium (induction agent, nondepolarizing neuromuscular blockade) pros and cons
Pros: minimal CV effects, reversible with sugammadex
Cons: decreased clearence in hepatic insufficiency, caution in patients with difficult airway
How is vecuronium different from rocuronium?
Longer time to paralysis
HFNC max flow
2 L/kg/min
(or ~12L/min for infants/toddlers, ~30L/min for children, and ~50L/min for adolescents)
Goal tidal volume (Vt) in mechanical ventilation to avoid volutrauma
4-6 mL/kg
Goal peak inspiratory pressure (PIP) in mechanical ventilation to avoid barotrauma
<35 cmH2O
Max FiO2 in mechanical ventilation to avoid oxygen toxicity
FiO2 < 60%
Indications for SBT
FiO2<50%, PEEP=5, PIP<20, RR wnl, acid/base wnl
What is the first and most sensitive VS change before shock?
Tachycardia
What is something you should do in all etiologies of shock?
Administer 100% supplemental oxygen
Dobutamine mechanism and use (in shock)
Selective B1 agonist
For normotensive, poorly perfused shock
(Beware arrythmias)
Dopamine mechanism and use (in shock)
Stimulates NE release, direct alpha agonism at high doses. Ionotrope.
For shock with poor contractility
Milrinone mechanism and use (in shock)
Type 3 PDEi, ionodilator, improve CO with minimal effect on HR
For normotensive shock with myocardial dysfunction
Epinephrine mechanism and use (in shock)
B1/B2/A1 agonist
Hypotensive shock, cold septic shock
Norepinephrine mechanism and use (in shock)
B1/A1 agonist
Warm shock, low SVR
Phenylephrine mechanism and use (in shock)
Pure A1 agonist
General vasoconstrictor
(Beware reflex bradycardia)
Vasopressin (ADH) use (in shock)
For cardiac arrest, refractory hypotension in septic shock, and GI hemorrhage
Blood product dose in hemorrhagic shock
10 mL/kg boluses of PRBCs
IM epi dose in anaphylaxis
0.01 mg/kg/dose, max 0.3mg/dose.
redose every 5-15 minutes
Definition of pulmonary hypertension
resting mean pulmonary arterial pressure (PAP) >25 mmHg among children >3 months
Hypertensive emergency definition
BP acutely >99%ile with signs of end organ damage (encephalopathy, vision disturbance, CHF, AKI)
Hypertensive urgency definition
BP acutely >99%ile with NO signs of end organ damage
What is a goal rate of correction of BP in hypertensive emergency/urgency?
reduce BP by 25% in the first 8 hours, then gradual normalization over the next 24-48 hours
4 meds you can use in a tet spell
ketamine (increases SVR, sedating), morphine (sedating, suppresses hyperpnea), phenylephrine (increases SVR), propranolol (increases ventricular filling)
Lethargy
depressed consciousness resembling sleep from which a patient may be briefly aroused by stimulation
Stupor
depressed consciousness resembling sleep from which a patient may be briefly aroused only with profound stimulation
GCS: what are the categories and how many points each?
EVM: Eye 4, Verbal 5, Movement 6
Initial management of symptomatic hyponatremia
3-5 mL/kg bolus of 3% HTS over 15-30 minutes until seizure stops or serum sodium >125
Complex febrile seizure definition
At least one of the following: duration >15 minutes, more than one within 24 hours, or focal onset
What pressure is diagnostic of elevated ICP?
At least 20 mmHg
When does the PDA close?
DOL 5-10
PE ECG finding
Sinus tachy with S1Q3T3
5 H’s (reversible causes of PEA arrest)
Hypoxia, hypothermia, hypoglycemia, hyper/hypokalemia, hypovolemia, H+ (acidosis)
5 T’s (reversible causes of PEA arrest)
Tension pneumo, tamponade, thrombus (PE, MI), toxins, trauma