HIVSH1

Question 1

Fusion

Answer 1

HIV Fusing with cell membrane of CD4. Release cytoplasm into the CD4 cell = entry = binding and fusion
Once single stranded HIV RNA inside the cell the next step is reverse transcription ( transcription: double stranded DNA transcribed into single stranded messenger RNA). Reverse transcription is the opposite

Single stranded HIV RNA turning itself into a double stranded HIV DNA. Done by HIV enzyme called reverse transcriptase.
Once you have HIV DNA, whole reason for this whole reverse transcription was for HIV virus to get double stranded DNA. This double stranded HIV DNA can integrate itself with the host cell DNA ( which also is double stranded DNA ). = integration. Done by enzyme integrase.

Now when host cell dna replicates, it’ll automatically replicate HIV DNA with itself at the same time. Thats how HIV virus uses CD 4 to replaicate its genetics material. Transcription and translation. = messenger RNA gets encoded to amino acid chain. Long chain. Needs to broken down to functional units.

Question 2

LAND FIRST pneumonic

Question 3

Viral enzymes gets made for HIV RNA virus to bud off host cell.

Question 4

First set of medications are gonna be entry inhibitors.
Entry: binding and fusion

Answer 4

Binding inhibitors: ibalizumab

Fusion inhibitors: enfuvirtide

Question 5

NRTI side effects all have SE’s that are common to the whole class

Answer 5

T

Lactic acidosis
Headache

And #3) fatty liver : hepatic statosis

Question 6

NNRTIs common SE:

Answer 6

Rash

Hepatotoxicity

Question 7

Integrase inhibitors

Answer 7

RBED

GI
Nausea
HA
Fatigue

Question 8

Protease inhbitors

Answer 8

LAND FIRST
All end with navir

All can cause hyperglycemia, hyperlipdemia and Lipodystophy

Question 9

First step inside the cell is

Answer 9

Transcription

NRTis and NNRTIs are first step inside the cell blocker

Question 10

Last step before viral genetic material and viral enzymes bud off are

Answer 10

Protease inhibitors

Question 11

Inducers pneumonic

Answer 11

SRCOP

S-st John’s wort / Sustiva ( efavirenz )
R- rifampin /
C- carbamazapine
O- Oxcarbamazapine
P- pheytoin and phenobarbital