HIV Slides 14-27: Drugs

Question 1

What is the preferred regimen in HLAB5701 negative patients?

Answer 1

Dolutegravir (DTG) + Abacavir (ABC) + Lamivudine (3TC)

INSTI based

Question 2

What is the preferred regimen in patients with CrCL over 30 mL/min but less than 70 mL/min?

Answer 2

Elvitegravir (EVG) + Cobicistat (C) + Tenofovir alafenamide (TAF) + Emtricitabine (FTC)

INSTI based

Question 3

What is the preferred regimen in patients with CrCL over 70 mL/min?

Answer 3

Elvitegravir (EVG) + Cobicistat (C) + Tenofovir disoproxil fumarate (TDF) + Emtricitabine (FTC)

INSTI based

Question 4

What is the only PI based regimen?

Answer 4

Ritonavir (R) boosted Darunavir (DRV) + Tenofovir disoproxil fumarate (TDF) + Emtricitabine (FTC)

Question 5

What are the 2 INSTI based preferred regimens that aren’t specific to any patient population?

Answer 5

Dolutegravir (DTG) + Tenofovir alafenamide (TAF) + Emtricitabine (FTC)

Raltegravir (RAL) + Tenofovir disoproxil fumarate (TDF) + Emtricitabine (FTC)

Question 6

What do all nucleoside analog inhibitors of reverse transcriptase have in common?

Answer 6

All require intracellular phosphorylation to be effective

Question 7

What do all nonnucleoside reverse transcriptase inhibitors have in common?

Answer 7

They should not be used alone because of resistance development

Also they are not effective in HIV-2

Question 8

Name the nucleoside analog inhibitors of reverse transcriptase (7)

Answer 8

Abacavir
Didanosine
Emtricitabine
Lamivudine
Stavudine
Tenofovir
Zidovudine

Question 9

Name the nonnucleoside reverse transcriptase inhibitors?

Answer 9

Delavirdine
Efavirenz - preferred agent!
Etravirine
Nevirapine
Rilpivirine

Question 10

Name the protease inhibitors

Answer 10

Atazanavir
Darunavir
Fosamprenavir
Indinavir
Lopinavir/Ritonavir boosted
Nelfinavir
Ritonavir (only used to boost other agents; potent inhibitor of CYP3A4)
Saquinavir
Tipranavir

Question 11

Name the integrase inhibitors

Answer 11

Dolutegravir
Raltegravir
Elvitegravir (Only available co-formulated)

Question 12

How does Maraviroc work?

Answer 12

CCR5 antagonist; receptors on CD4 cells exist as CCR5 or CXCR4 or mixture

Binding is necessary for fusion of viral and host membranes

Question 13

As CD4 counts decrease, which receptor increases?

Answer 13

CXCR4

Question 14

How does Enfuviritide work?

Answer 14

Blocks fusion of virus with T-cell membrane