HIV in pregnancy

Question 1

All pregnant women with HIV should receive …, as early as possible in the pregnancy, regardless of CD4 count or viral load.

Answer 1

All pregnant women with HIV should receive antiretroviral therapy (ART), as early as possible in the pregnancy, regardless of CD4 count or viral load.

Question 2

The first line of investigation for suspected HIV in pregnancy is …, …, and neonatal ….

Answer 2

The first line of investigation for suspected HIV in pregnancy is maternal HIV-1/HIV-2 antigen/antibody enzyme-linked immunosorbent assay (ELISA), maternal HIV-1/HIV-2 antibody differentiation immunoassay, and neonatal HIV DNA or RNA polymerase chain reaction (PCR).

Question 3

The preferred first-line treatment for HIV-1-infected pregnant women who are <38 weeks and not in labour (regardless of HIV RNA level) is …?

Answer 3

Two nucleoside reverse transcriptase inhibitors are recommended as the backbone of combination regimens: abacavir/lamivudine

Question 4

The first-line treatment for HIV-1-infected pregnant women with HIV-1 RNA levels >1000 copies/mL and who are at 38 weeks or in labour is…?

Answer 4

• elective Caesarean section
• plus zidovudine, and continue antiretroviral therapy

Question 5

The first-line treatment for HIV-1-infected pregnant women with HIV-1 RNA levels ≤1000 copies/mL and who are at 38 weeks or in labour is…?

Answer 5

normal vaginal delivery, plus continue antiretroviral therapy.
consider zidovudine