HIV Drugs and Miscellaneous

Question 1

Genome type of HIV? Enveloped or no?

Answer 1

Positive sense ssRNA x2

Enveloped

Question 2

3-in-1 enzyme functions?

Answer 2

RNA dep DNA pol, DNA dep DNA pol, RNase H

Question 3

Life cycle phases?

Answer 3

Attachment
Entry
Uncoating
Synthesis of protein and nucleic acid
Assembly
Release

Question 4

What part of HIV virus interacts with CCR5 or CXCR4?

Answer 4

sequences within gp120

Question 5

CCR5 and CXCR4 are found where?

Answer 5

on CD4 cell surface

Question 6

Co-receptor binding site is found where?

Answer 6

gp120

Question 7

Co-receptor binding triggers a conformational change in what?

Answer 7

gp41 subunit

Question 8

What is the receptor for HIV?

What is the “co-receptor”?

Answer 8

CD4

CCR5 or CXCR4

Question 9

Most commonly used agents?

Answer 9

RT inhibitors

Question 10

Zidovudine/Retrovir/AZT - MOA?

Answer 10

NRTI - competitive binding of RT to terminate DNA chain elongation

Question 11

Which drug has serious hypersensitivity reaction risk?

Answer 11

Abacavir (also cardiac risk)

Question 12

Which drug has IV form?

Answer 12

AZT

Question 13

Which drugs are effective for Hep B?

Answer 13

Lamivudine/Emtricitabine and Tenofovir

Question 14

Lamivudine is commonly used with ___?

Answer 14

AZT or tenofovir

Question 15

TDF or TAF less toxic?

Answer 15

TAF has less renal and bone toxicity

Question 16

Lopinavir MOA?

Answer 16

Protease inhibitor

Question 17

Raltegravir MOA?

Answer 17

Integrase inhibitor

Question 18

Raltegravir benefits?

Answer 18

well tolerated and few side effects

Question 19

Maraviroc MOA?

Answer 19

unique - inhibits co-receptor (but may not be active in all stages of disease)

Question 20

Lopinavir drawbacks?

Answer 20

potent, need to be aware of drug interactions

Question 21

NRTI drugs?

Answer 21

Tenofovir (TDF and TAF) and AZT/Zidovudine

Question 22

Lopinavir/Ritonavir use?

Answer 22

boost levels of primary drugs

Question 23

standard of care before starting Abacavir?

Answer 23

Check HLA-B5701