HIV Drugs

Question 1

ART - Antiretroviral Therapy

Answer 1

Usually a combo of 2-3 of several drugs

Question 2

Fusion Inhibitors

Answer 2

Fuzeon

Prevents cellular fusion between HIV & CD4+

Question 3

Entry Inhibitors/CCR5 Antagonist

Answer 3

Blocks CD4+ coreceptor from docking with HIV virus

Question 4

Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)

Answer 4

Acts by blocking the RNA from turning into DNA

Question 5

Nucleoside Analog Reverse Transcriptase Inhibitors (NRTIs)

Need to know one drug from this classification

Answer 5

Acts by joining with the DNA the virus has made and creates “bad” DNA that can’t form new viruses

Abacavir (Ziagen)

Question 6

Integrase Inhibitors

Answer 6

Inhibits the HIV integrase thereby stopping the integrase from putting the viral DNA in the host DNA inside the nucleus

Question 7

Protease Inhibitors

2 drugs

Answer 7

Inhibits the HIV protease by stopping the long strand of protein from being chemically “cut” by the protease and thereby stopping it from releasing small particles of the virus
Indinavir (Crixivan)
Nelfinavir (Viracept). This one take with food. Diarrhea is common side effect

Question 8

Combination Drugs

Answer 8

Increases pt adherence due to less meds

Combivir

Question 9

Immune Stimulating Drugs (one med)

Answer 9

Cytokine (hormone) that regulates activities of WBC. This stimulates the WBC in the immune system:
Interleukin 2

Question 10

Interferon

Answer 10

Interferes with viral replication of the virus in the host cell, makes infected/tumor cells stand out T-cells and macrophages. Activates the T-cells and macrophages. Also used in cancer pts

Question 11

Interleukin 2

Answer 11

Cytokine - immune boosting med

Question 12

Abacavir (Ziagen)

Answer 12

Nucleoside Analog Reverse Transcriptase Inhibitor (NRTI)

Makes “bad” DNA

Question 13

Indinavir (Crixivan)

Answer 13

Protease Inhibitor

Question 14

Nelfinavir (Viracept)

Answer 14

Protease Inhibitor