HIV Drug Classes

Question 1

NRTI agents (nucleoSide)

Answer 1

Lamivudine (3TC)
Emtricitabine (FTC)
Abacavir (ABC)

Question 2

NRTI agents (nucleoTide)

Answer 2

Tenofovir Disoproxil (TDF)
Tenofovir alafenamide (TAF)

Question 3

NRTI (nucleoSide) MOA

Answer 3

Inhibits HIV reverse transcriptase by incorporating nucleosides that lack 3’-OH group
Terminates viral dsDNA growth from ssRNA

Question 4

NRTI (nucleoTide) MOA

Answer 4

Nucleotide RT Inhibitors
Inhibits HIV reverse transcriptase by incorporating nucleosides that lack 3’-OH group
Terminates viral dsDNA growth from ssRNA

Question 5

INSTI MOA

Answer 5

HIV integrase inhibitor

Prevents HIV DNA insertion into host cell genome

Question 6

INSTI agents

Answer 6

Raltegravir (RAL)
Dolutegravir (DTG)
Elvitegravir (EVG)
Bictegravir

Question 7

NNRTI MOA

Answer 7

Non-nucleoside reverse transcriptase inhibitor

Noncompetitor inhibition of HIV RT

Question 8

NNRTI agents

Answer 8

Efavirenz (EFV)
Etravirine (ETR)
Rilpivirine (RPV)

Question 9

PI MOA

Answer 9

Prevents formation of mature virions by selectively inhibits virus proteases

Prevents HIV from being cut into smaller proteins for assembly into new infectious particles

Question 10

PI agents

Answer 10

Darunavir (DRV)

Atazanavir (ATV)

Question 11

PK boosters

Answer 11

Cobicistat (c)

Ritonavir (R)

Question 12

Cobicistat MOA

Answer 12

Boosts concentrations of protease inhibitors by inhibiting CYP450 ( CYP3A) family and P-gp efflux pumps

Question 13

Ritonavir MOA

Answer 13

Inhibits CYP3A4, P-gp, OATP, CYP2c9, 2C19, 2Bg

In addition to PK booster, also a protease inhibitor