HIV & Antiretrovirals Flashcards
Abacavir
ABC
NRTI
Ziagen
Didanosine
ddI
NRTI
Videx EC
Emtricitabine
FTC
NRTI
Emtriva
Lamivudine
3TC
NRTI
Epivir
stavudine
d4t
NRTI
Zerit
tenofovir
TDF
NRTI
Viread
zidovudine
ZDV or AZT
NRTI
Retrovir
Delaviridine
DLV
NNRTI
Rescriptor
Efaviranz
EFV
NNRTI
Sustiva
Atripla
Nevirapine
NVP
NNRTI
Viramune
Rilpivirine
RPV
NNRTI
Endurant
Complera
Atazanavir
ATV/r or ATV
PI
Reyataz
Darunavir
DRV/r
PI
prezista
fosamprenavir
FPV/r or FPV
PI
Lexiva
indinavir
IDV/r or IDV
PI
crixivan
Lopinavir
LPV/r
PI
Kaletra
Neflinavir
NFV
PI
viracept
Ritonavir
RTV or /r
PI
norvir
Saquinavir
SQV/r
PI
Invirase
Tipranavir
TPV
PI
Aptivus
enfuvirtide
T20
fusion inhibitor
maraviroc
MVC
CCR5 antagonist
raltegravir
RAL
Integrase inhibitor
Elvitegravir
EVG
integrase inhibitor
what is aa normal CD4 count?
500-1000 cell/mm3 or greater
what is the cutoff point CD4 count for AIDS?
<200 cell/mm3
what does having a low cd4 count pts at risk for?
opportunistic infections
malignancies
non-aids related complications
what does the viral load measure?
HIV-1 RNA levels in he blood .
Helps you track the effeicacy of ART
which conditions are considered AIDS defining conditions?
Bacteria -histoplamsosis -MAC -TB -PJP -salmonelace spticemia recurrent -toxoplasmosis Fungus -recurrent vagina candidasis or candidtiasis of lungs, trachea, esophagus but not oral Virus -CMV -HSV Malignacies: kaposi's sarcoma, etc Other: -cryptosporidiosis -encephalopathy -HIV wasting syndrome
who should be routinely tested for HIV according to the CDC?
All americans 13-64 years old -new TB infections -STD treatemt -pregnant women high risk people : MSM , IVDU
what are some of the Non-AIDS releated complications of HIV?
CV disease appearing more frequent and at an earlier age
Renal disease
Liver disease progression (leading cause)
cognitive impairment (dementia)
what may be contributing to the increase in the mortality of HIV patients?
there is always T cell activation and inflammation. Long term inflamation may be the cause of inc mortality
what are the top 5 signs and simptoms of an acute HIV infection?
2-8 weeks after exposure the patient has flu-like symptoms that resolve
- Fever
- Lymphadenopathy
- Pharyngitis
- Rash
- Myalgia/arthralgia
how long does it take for an HIV person to have seroconversion?
4-8 weeks after exposure
which 5 different test are there to test for HIV?
- Rapid HIV test
- ELISA (screening test)
- Western Blot
- OTC HIV test (Ora Quick)
- Viral load assay
Which of the tests serves as the confirmatory test for HIV (the final positive diagnosis)?
Western blot, all positive tests from other tests must be confirmed by this method
how fast is the rapid HIV test?
resuls take less than 60 minutes
how fast is the ELISA?
results in 1-2 days
How fast do you get results with the western blot?
2-3 weeks, sometimes longer
how quick is the OraQuick at geting reuslts?
20-40 mintues
how accurate is the OraQuick ?
92% of time catches the HIV+ patients
99% of the time catches the HIV negative patients
what are risk factors for gettign HIV?
- Blood transfusiton before 1985 fro HIV1, before 1992 for HIV 2
- needle sharing IVDU
- anal > vaginal sexual episode
- perinatal transmission through breastfeeding > 50% risk
- needle stick
Has ART been shown to decrease transmission of HIV?
Yes in serodiscordant couples, who started immediate ART , a study showed that there was 97% HIV transmission reduction (HPTN 052 study)
Which medicaitons was approved in July 2012 to reduce HIV transmission? what is this therapy called?
Tenofovir/emtricitibine (Truvada) for HIV negative individuals (discordant couples / MSM) before sexual couples with HIV + partner. It hisis called PrEP (Pre-exposure prophylaxis)
By how much is PrEP supposed to stop HIV Transmission?
Maximum 73% HIV transmission if > 90%. Drops with decreased adherence
who is eligible for PrEP according to the CDC?
- High risk of acquirng HIV
- documented HIV/HBV negative
- Confirmed CrCL >60ml/min (TDF)
- StD and HCV screened and treat
- avoid PrEP in breast feeding women
dosing for PrEP
Truvada one tablet daily max 90 days supply
must give risk reduction, adherence counseling/condoms
what should you monitor in PrEP patients?
HIV ab and preg test q 2-3 motnhs and when PrEP stopped.
Scr and bone loss
-adherence and HIV risk
what are the toxicities of truvada long term?
renal toxicity
bone demineralization
uknone about risk to fetus/ hiv negative people long term
who should get Post-exposure prophylaxis? PEP
- After a needle stick
- mucocutaneous or cutaneous exposure to blood or body fluids
- after risky sex
- IVDU
- sexual assault
which fluids can transmit HIV and which cant?
YES: blood, semen, vaginal fluids , breast milk
NO: saliva, vomit, urine, feces , sweat , tears, respiratory secretions
how soon should you take the PEP?
ASAP , accoding to CDC 72 hour wind based on animal data, NY up to 36 hours based on amimal data
Dose of PEP agents and duration?
Truvada 1 po daily x 28 days or combivir po bid x 28 days
PLUS
Raltegravir 400mg po bid or poretease inhibitors
Avoid NNRTIs
what clinical marker do you follow for HIV therapy?
HIV-RNA level (viral load), want it to drop as quick as possible within first 4-6 weeks
goals of HIV therapy? why start treatment?
improve QOL reduce mortality and morbidity reduce progression to AIDS decrease inflammation and its complications decrease transmission of HIV
when should you obtain genotype testing for HIV + patients?
at the time of diagnosis
before starting ART
if pregnant
what baseline tests should you order before starting ART?
CD$ cell count Viral load HLA-B5701 allele (if abacavir) CBC w/ differential LFTs FBG SCr, BUN, UA fasting lipids Hep A, B, C serology assess adherence!! mediations history comorbidities
what is the typical skeleton of HAART?
2 NRTIs + [NNRTI or PI or INSTI]
Efavirenz dose for preferred regimen and MOA
NNRTI
60mg po daily
Truvada
tenofovir 300 / emtricitabine 200
truvada dose for preferred regimen
1 tab po daily
when should you avoid truvada?
CrCL < 30 ml/min