HIV and AIDS Flashcards
Pathophysiology of HIV Infection and AIDS
HIV is a retrovirus that causes a chronic disorder of impaired immunity; HIV can progress to AIDS; Individuals with AIDS are profoundly immunocompromised
Stage 1 of HIV
- Begins with onset of acute infection responses after an initial invasion by the virus causes overt symptom
- This stage is relatively short and in most infected adults can progress over time to the HIV disease chronic stage of HIV-II
Stage 2 of HIV
Stage HIV- II is considered as the chronic HIV illness
May last for years due to current medications
First, intermittent acute infections followed by periods or relative wellness
Secondly, chronic progressive debilitation occurs
Stage 3 of HIV
Stage HIV-III is the final, most serious form of HIV known as AIDS.
Severe reduction of immunity and increased risk for cancer
May live for years before dying
Signs and Symptoms
- Fever
- Sore throat
- Rash
- Night Sweats
- Chills
- Headache
- Muscle Ache
Classification of HIV
Class 0: Patient develops a first positive HIV test result within 6 months after a negative HIV test result. CD4+ T-cell counts are usually in the normal range and no AIDS-defining condition is present.
Class 1: Patient has a CD4+ T-cell count of greater than 500 cells/mm3 (0.5 X 109/L) or a percentage of 29% or greater. No AIDS-defining illnesses are present. (HIV-I)
Class 2: Patient has a CD4+ T-cell count between 200 and 499 cells/mm3 (0.2 to 0.499 X 109/L) or a percentage between 14% and 28%. No AIDS-defining illnesses are present. (HIV-II)
Stage HIV-III
Class 3: Patient has a CD4+ T-cell count of less than 200 cells/mm3 (0.2 X 109/L) or a percentage of less than 14%. Any patient, regardless of CD4+ T-cell counts or percentages who has an AIDS-defining illness. AIDS diagnosis.
Unknown:
> Patient has a confirmed HIV infection but no information regarding CD4+ T-cell counts, CD4+ T-cell percentages, and AIDS-defining illnesses is available.
HIV Infectious Process
Stage 1:
> Develop an acute infection within 4 weeks of being infected (Flu-like symptoms)
Stage 2:
> Infected adults are diagnosed
> Appropriate drug therapy suppress viral reproduction, allowing the patient to maintain a relatively level of immunity for protection
> Because drug therapy only suppress viral reproduction and does not kill the organism, eventually many patients progress to stage 3
> Poor CD4+ T-Cell function leads too:
> Leukopenia (decreased number of circulating WBC)
> Lymphocytopenia (decreased number of lymphocytes)
> Production of incomplete and non functional antibodies
> Abnormally functioning macrophages
> At risk for bacterial, fungal, viral infections and opportunistic cancers
Stage 3:
> CD4+ T-Cell of less than 200 cells/mm3 or an opportunistic infection
HIV Progression
- The time from the beginning of HIV-I infection to HIV-III ranges from months to years depending on how HIV is acquired, other health problems, personal factors, and interventions
- When HIV results from a single sexual encounter, progression takes longer
- Personal Factors influencing time to progression include:
> Frequency of Re-exposure
> Presence of other STIs
> Nutrition status
> Stress - Infection within first four weeks of infection
> May not even consider they have HIV- just think they have a cold
> Will begin to feel better when symptom relieve, but the disease is only starting
> When viral numbers are in the bloodstream and genital tract, sexual transmission is possible - May have a few symptoms, but as progression occurs, more health problems occur
> Coughing, SOB
> Diarrhea, weight loss, N/V
> Dry skin or lesions, poor wound healing, night sweats
> Confusion, dementia, memory loss, HA, fever, visual changes, personality changes, seizures
Health Promotion and Maintenance
- HIV and AIDS cannot be cured, the continued use of antiretroviral therapy allows patients to live longer, healthier lives*
- Teach all adults about the transmission routes and ways to reduce their exposure*
- Stress that HIV is not transmitted through casual contact in the home, school, or workplace
- Sharing household utensils, towels and linens, and toilet facilities does not transmit HIV
- HIV is not spread by mosquitos or other insects
Infected Fluids with Highest HIV Concentrations
- Blood
- Semen
- Breast Milk
- Vaginal Secretions
Infected Fluids with Lowest HIV Concentration
- Tears
- Saliva
- Sweat
*Low risk for transmission unless obvious blood is present
HIV is Transmitted in Three Ways
- Sexual
- Parenteral
- Perinatal
HIV Staus
- Early diagnosis allows for early treatment and prevention, a concept known as Treatment As Prevention (TAP)
- Recommendations for HIV Screening:
> One-time screening between ages 15-65
> An annual screening for those who are at greater risk for HIV infection
> Prenatal screening
> Frequent testing in adults with repeated high-risk exposures - Testing help prevention because test can diagnose HIV infection before immunity changes or disease symptoms develop
- ALL SEXUALLY ACTIVE ADULTS SHOULD KNOW THEIR HIV STATUS
Recommendations for Annual HIV Testing and One-Time Screening
You should be tested annually for HIV if you:
- Have a sexually transmitted disease
- Use injection drugs
- Consider yourself a risk
- Are a women of child bearing age with identifiable risks including
> Used injection drugs
> Engaged in sex work
> Had sexual partners who were infected or at risk
> Had sexual contact with men from countries with high HIV prevalence - Received a blood product transfusion between 1978 and 1985
- Plan to get married
- Are undergoing medical evaluation or treatment for symptoms that may be HIV related
- Have been or are in a correctional institution such as jail and prison
- Are a sex worker or have had sex with a sex worker
- Between the age of 18-65
- As part of routine prenatal screening when you are pregnant
Sexual Tranmission
- Genital, anal, or oral sexual contact with exposure of mucous membranes to infected semen or vaginal secretions
- Abstinence or mutually monogamous sex with a noninfected partner is ONLY absolute way of preventing infection
- The risk for becoming infected from a partner with HIV positive and has a detectable viral load is always present
- Sexual Acts of Practices in which infected seminal fluid come is contact with mucous membranes or non intact skin are the most risky for sexual transmission of HIV
- Viral Load, the amount of virus present in blood and other body fluids, affects transmission
- Safe Sex Practice
- reduce instances where non-intact skin or mucous membranes come in contact with HIV-infected blood/body fluids- use latex or polyurethane condoms for both genital and anal intercourse
- use water-based lubricant with a latex condom
- use a condom or other latex barrier (dental dam) during oral-genital or oral-anal contact
- use latex gloves for finger/hand contact with a vagina or rectum
Safe Sex Practices
- Reduce instances where non-intact skin or mucous membranes come in contact with HIV-infected blood/body fluids
- Use latex or polyurethane condoms for both genital and anal intercourse
- Use water-based lubricant with a latex condom
- Use a condom or other latex barrier (dental dam) during oral-genital or oral-anal contact
- Use latex gloves for finger/hand contact with a vagina or rectum
Pre-Exposure Prophylaxis (PrEP)
- Use of HIV antiretroviral drugs by an HIV-UNINFECTED adult to prevent HIV infection
- Used for people who are at high risk for acquiring HIV infection such as:
> Men who have sex with men
> Nonmonogamous heterosexually active men and women
> Injection drug users
> Relationship in which one partner is HIV positive and one partner is HIV negative - Important to ensure the adult is HIV negative using a HIV antigen/antibody test
> Other tests include: kidney function, other test for STI, liver function, and Hep. A,B,C - After starting PrEP, ongoing testing of kidney function and HIV infection is performed q3 months because both drugs can be toxic to kidney and liver
- PrEP is not protected until 7 days of consistent dosing allows a steady-state blood drug level to be achieved
- When the initial period is completed, one dose can be missed and protection is still adequate
- If two consecutively missed doses greatly reduce protection and the patient needs to start over with another 7-day lead in period until the new steady state is achieved before being sexually active.
Postexposture Prophylaxis (PEP)
- PEP with cART is used for adults who have had:
> Occupational Exposure (sharps injury)
> Non-occupational Exposure (consensual sexual exposure with a person of unknown HIV status)
> Those who suffered a sexual assault
- Starting cART as soon as possible (within 36 hours) is critical to preventing HIV infection
- Occupational Exposure: contact between blood, tissue or selected bodily fluids from a patient who is positive for HIV and the blood, broken skin, or mucus membranes of a health care professional
> Most cases of occupational exposure requiring PEP involve a percutaneous needle stick with a needle
> STEPS:
1. Washing the wound carefully for 1 full minute
2. Immediately contact employee health to begin documentation, testing and prophylaxis
3. cART with 2 hours of exposure has the best outcome in preventing HIV infection
4. Return for HIV testing every 1, 3 and 6 months
5. Electrolytes, CBC, Creatine checked 2 weeks after starting cART - Nonoccupational Exposure
> Consensual and nonconsensual sexual exposures, involving insertive and receptive types of sex with oral, vaginal or anal contact
> Other types include sharing of needles and inadvertent percutaneous or mucosal contact in the home - Exposure to HIV as a result of sexual assault also includes testing for other STIs. For women of child-bearing age, emergency contraception is offered
Parenteral Transmission
- Sharing of needles (sharps) or equipment contaminated with infected blood or receiving contaminated blood products*
- Preventive Practices
> Proper cleaning of needles, syringes and other drug paraphernalia
> Clean a used needle and syringe by first filling and flushing them with clear water
> Teach them to fill the syringe with ordinary household bleach and shake it for 30-60 seconds
> Advise IDU to carry a small container with this solution whenever sharing needles or to participate in community needle exchange programs - Transmission of HIV through blood transfusion is very low
> All blood is screened
Perinatal Transmission
- From the placenta, from contact with maternal blood and body fluids during birth, or from breast milk from an infected mother to child*
- Inform women of child-bearing age with HIV infection about the risks for perinatal transmission
- Encourage HIV-positive women who are pregnant to continue the therapy or, if they are not on antiviral therapy, to start the therapy as soon as possible
Transmission and Health Care Workers
- Needlestick and “sharps” injuries are the main means of occupation-related HIV infection for health care workers
- Can also be infected through exposure of non intact skin and mucous membranes to blood and body fluid
- To prevent HIV transmission to patients, health care workers must wear gloves when in contact with patients’ mucous membranes or non intact skin
- Infected workers with weeping dermatitis must wear gloves or not perform direct patient care
Nursing Assessment: Health History
Ask About:
1. Gender, Age, Occupation and Home Environment
2. Assess current illness (when it started, severity of symptoms, associated problems and interventions)
3. When was HIV infection diagnosed and which symptoms led to that diagnosis
4. Give chronologic history of infections and problems since diagnosis
5. Ask about sex practices, STIs, and infectious diseases
6. Ask whether they have engaged in past or present injection drug use
7. Assess cognitive function and knowledge level of the diagnosis, symptom management, diagnostic tests, treatments, community resources and modes of HIV transmission
8. Assess safer sex practices and provide appropriate teaching
Physical Assessment/Sign and Symptoms
Immunologic:
1. Low white blood cell count (<200 cells/mm3)
2. High blood immunoglobulin levels
3. Opportunistic Infections
4. Lymphadenopathy
Integumentary:
1. Dry skin, lesions
2. Poor wound healing
3. Night Sweats
Respiratory:
1. Cough, shortness of breath
GI:
1. Diarrhea
2. Weight loss
3. Nausea and Vomiting
CNS:
1. Confusion, dementia, memory loss
2. Headache
3. Fever
4. Visual change
5. Personality changes
6. Seizures
Viral Infection:
1. Cytomegalovirus
Bacterial Infection:
1. Tuberculosis
Fungal Infection:
1. Candidiasis
2. Pneumocystis jiroveci pneumonia
Malignancies:
1. Kaposi’s sarcoma
Protozoal Infection:
1. Cryptosporidiosis
Nursing Assessment: Psychosocial Assessment
- Assess baseline neurologic and mental status
- Evaluate the patient for subtle changes in memory, ability to concentrate, affect and behavior
- Ask about social support system (family, friends, significant other)
- Assess patient’s feelings, thoughts and behaviors (anxiety, mood, cognition, energy, and activity level)
- The patient with HIV disease HIV-III has less energy as the disease progresses. Pace interviews, assessments and interventions to match his or her energy levels*