HIV AMT Flashcards
nucleoside analogs and bind to active site of RT
NRTIs
bind elsewhere on the RT enzyme to modify its function
NNRTIs
these drugs prevent binding
CCR5 antagonist
these drugs blocks integrase, prevent gDNA integration and replication
Integrase strand transfer inhibitor
interferes with early interaction with gp120 of HIV and CD4 on host
attachment inhibitors
binds to CD4 receptor and blocks attachment of HIV to CCR5 and CXCR4 co-receptors, preventing entry
post-attachment inhibitors
lowest viral quantity that can be detected
limit of detection
lowest viral quantity that can be quantified (assigned a numerical value)
lower limit of quanitification
a confirmed HIV-RNA level below the LLOD of available assays
virologic suppression
the inability to achieve or maintain suppression of viral replication to HIV-RNA level <200 copies/mL
virologic failure
two consecutive plasma HIV-RNA levels > 200 copies/mL after 24 weeks on an ARV regimen in a patient who has not yet had documented virologic suppression on that regimen. A patients baseline HIV-RNA level may affect the time course of response, and some regimens may take longer that others to suppress HIV-RNA levels
incomplete virologic response
after virologic suppression, confirmed HIV-RNA level > 200 copies/ mL
virologic rebound
after virologic suppression, an isolated detectable HIV-RNA level that is followed by a return to virologic suppression
virologic blip
confirmed detectable HIV-RNA level < 200 copies/mL
low-level viremia
taken every day to prevent HIV infection in higher-risk individuals
Pre exposure prophylaxis (PrEP)
drugs taken when there is a single high risk event
post exposure prophylaxis
