HIV Flashcards
NRTI drugs sideffects
Nucleoside analogues-
Older -Zidovudine, stavudine(pancreatitis) -Lipodystrophy/atrophy
Lamivudine, emtricitabine,abacavir (HLAB1507 sensitivity, CV risk, rash)
Nucleotide analogue- Tenofovir( Renal dysfunction , osteoporosis)
NNRTI drugs side effects
Nevirapine -Rash ,hepatitis
Efavirens - neuropsychiatric, suicidal
2nd gen
Etravirine, Rilpivirine
Protease inhibitors
Less likely chances of resistance
Atazanavir- hyperbilirubinemia, renal stones, hyperlipidemia -all drugs
Darunavir -as above
Lopinavir/ ritonavir
Fusion inhibitors
Enfuvirtide
CCR5 inhibitors -Maraviroc
Integrase strand transfer inhibitors
Raltegravir
Dolutegravir -most potent, daily dosing, high barrier to resistance
Elvitegravir
ART regimen for ART naïve patient
2 NRTI + 3rd agent
HIV virological suppression
HIV RNA <20 copies
Incomplete virological response
Inability to achieve virological suppression after 24 weeks of Rx - copies >200/ml on 2 consecutive samples
Virological failure - inability to maintain virological suppression to <200 copies
PreP Regimen
Tenofovir+ Emtricitabine
Differences between HIV 1 and HIV 2
Distribution -Worlwide vs Africa/Europe Viral load - High vs Low CD4 Tcells - Low vs High Replication, progression -faster vs slower Coreceptor -CCR5,CXCR4 vs mutiple
Primary reservoir of HIV
Memory Tcells
Primary source -activated T cells
Mutation in coreceptor that confers resistance to HIV 1
Delta 32 mutation in CCR5
Role of HLA in HIV
HLA B507 protective early
HLA B2701 protective late
HLA B3503 -susceptible
HAART associated with increased risk of MI
Protease inhibitors
HAART causing indirect hyperbilirubinemia
Atazanavir
