HIV Flashcards
Why do NRTIs have few interactions?
Because they are activated intracellularly.
Side effects of NRTIs?
They strongly inhibit mitochondrial DNA polymerase.
lactic acidosis
Steatosis
Lipoatrophy
Name an NRTI
AZT (Zidovudine)
Tenofovir
Emtricitabine (FTC)
Name NNRTIs
Efavirenz
Nevirapine
Rilpivirine
Name some interactions of NNRTIs
They are metabolised by P450 enzymes so therefore decrease the metabolism of other drugs metabolised in this way e.g. rifampicin, carbemazipine,
Which mutation is key to resistance in NRTIs and NNRTIs?
K103.
Name some protease inhibitors.
Darunavir,
Ritonavir (boosts activity of others)
Atazanavir
Name some interactions of protease inhibitors.
They are metabolised by P450 enzymes so therefore decrease the metabolism of other drugs metabolised in this way e.g. rifampicin, carbemazipine,
Name an integrase inhibitor.
Raltegravir
Elvitegravir
Why do integrase inhibitors have very few interactions during their metabolism?
THey are metabolised by UGT1A1 which metabolises very few drugs, hence not many interactions,.
