HIV Flashcards
1
Q
5 HIV Drug Classes
A
- Nucleoside Reverse Transcriptase Inhibitors (NRTI)
- Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI)
- Protease Inhibitors
- Integrase Inhibitors
- Entry Inhibitors
2
Q
Nucleoside Reverse Transcriptase Inhibitors (NRTI) MOA
A
- Chain terminator
- Stops transcription to DS DNA
3
Q
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI) MOA
A
- Inhibits reverse transcriptase enzyme
4
Q
Protease Inhibitors
A
- Inhibits enzyme
5
Q
Integrase Inhibitors
A
- Inhibits enzyme
6
Q
Entry Inhibitors
A
- Inhibits entry into CD4 cell
7
Q
HIV Regimens Needs what 3 things?
A
- 2 NRTI plus
- at least 1 from another class
8
Q
INSTI-Based Regimen
A
- 2 NRTI plus
- Integrase Inhibitor
9
Q
PI-Based Regimen
A
- 2 NRTI plus
- Boosted Protease Inhibitor
10
Q
NRTIs (7)
A
- Abacavir (Ziagen)
- Lamivudine, 3TC (Epivir)
- Emtricitabine, FTC (Emtriva)
- Tenofovir, TDF (Viread)
- Zidovudine, ZDV or ATZ (Retrovir)
- Stavudine, d4T (Zerit)
- Didanosine, ddl (Videx)
11
Q
NRTIs - Key Features
A
- Renal dose adjustment (except abacavir)
- No CYP450 interactions
- Boxed warning: lactic acidosis & hepatomegaly w/ steatosis (zidovudine, stavudine, didanosine > others)
- Abacavir: hypersensivity - test for HLA-B*5701
- Tenofovir toxicities: nephrotoxicity, osteoporosis, Fanconi syndrome. Thought to be lower w/ tenofovir alafenamide
12
Q
Abacavir Brand
A
Ziagen
13
Q
Abacavir Class
A
NRTI
14
Q
Abacavir Dose
A
300 mg PO BID or
600 mg PO QD
15
Q
Abacavir Cautions
A
- Don’t mix with EtOH (incr abacavir levels)
- Caution in CVD due to possible incr risk of MI
