HIV Flashcards
What is the first line PI based regimen?
Darunavir/Ritonavir + Tenofovir/Emtricitabine (Truvada)
What are the first line INSTI based regimens?
Raltegravir + Tenofovir/Emtricitabine (Truvada)
Elvitegravir/Cobicistat/TAF/Emtricitabine (Genvoya)
Dolutegravir + Tenofovir/Emtricitabine (Truvada)
Dolutegravir + Abacavir/Lamivudine (Triumeq)
Which agents require a CrCL over 70 before starting?
Stribild (Elvitegravir / Cobicistat / Emtricitabine / Tenofovir)
Tenofovir
Cobicistat
Genvoya (Elvitegravir/Cobicistat/TAF/Emtricitabine)
Which agent requires you to be Treatment experienced before starting?
Etravirine
Which agent requires a low viral load? What is the cutoff?
Rilpivirine
(Also in complera)
Cutoff is viral load over 100,000 or CD4 below 200
Rilpiv = sounds like rip up = rip up the drug if you’re too far gone
Which agent has a CD4 cutoff? What is the cutoff?
Nevirapine
NEVer use if CD4 is over 400 in males or over 250 in females (risk of hepatotoxicity)
Which agents should be taken on an empty stomach?
Didanosine
Efavirenz
Indinavir
Aunt Diane is on a diet
When I don’t eat I have crazy dreams (Efavirenz)
Don’t eat indian food while taking Indinavir
What agents can be taken with HBV?
Emtricitabine
Tenofovir
Lamivudine
Need Tenofovir + one of the other agents for adequate suppression
Atripla, Complera, Stribild, Genvoya would be good
Emily takes ten lambs to Haley’s Bakery (HB)
She tripped on Jenn’s computer and has to build a new one
Which agent causes fat accumulation?
Indinavir (Crix belly)
This will cause an indent in your shirts bc it stretches out the stomach
Which agent is contraindicated with PPI’s?
Rilpivirine
Which agents are contraindicated with Fluticasone?
PI’s
1st line regimen Darunavir/Ritonavir + Truvada contraindicated
Which agents are contraindicated with simvastatin and lovastatin?
PI’s
Stribild and Genvoya
STRIBILD (Elvitegravir, Cobicistat, Emtricitabine, Tenofovir)
GENVOYA (elvitegravir, cobicistat, emtricitabine, tenofovir AF)
(1st line regimen Darunavir/Ritonavir + Truvada contraindicated)
Which agent is for treatment naive patients only?
Rilpivirine (R is for Rookie)
Remember this is also the one you can’t give if CD4 is too low!
(No complera either!!!)
What is the preferred agent in pregnancy?
Kaletra:
Lopinavir
Ritonavir
LR Little replicas
Kaletra = Callie had a baby (Sophia) who is a Little Replica of her
Which of the following antiretrovirals is the LEAST likely to cause lipoatrophy?
A: Zidovudine ᅚ
B: Emtricitabine ᅞ
C: Stavudine ᅞ
D: Didanosine
B: Emtricitabine ᅞ
Which of the following medications should be taken WITHOUT food?
A: Efavirenzᅞ
B: Elvitegravirᅞ
C: Rilpivirineᅞ
D: Raltegravir
A: Efavirenzᅞ
Also Didanosine, Indinasine
Which of the following antiretroviral medications is associated with nephrolithiasis?
Answer C was also accepted for this question.
ᅚ
A: Atazanavir ᅞ
B: Ritonavir ᅞ
C: Raltegravir ᅞ
D: Zidovudine
A: Atazanavir ᅞ
HIV 10
Which of the following NRTIs should NOT be co-administered due to the potential risk for CD4 cell toxicity (decline)?
A:Tenofovir and didanosine
B:Tenofovir and abacavir
C:Tenofovir and stavudine
D:Tenofovir and lamivudine
A:Tenofovir and didanosine
James is a 52-year old, HIV infected male on a regimen of darunavir, ritonavir, tenofovir, and emtricitabine. His physician would like to start a statin based on his most recent lipid panel and PMH. Based on the above, which of the following statins would you want to avoid giving James?
A: Rosuvastatin
B: Lovastatin
C: Atorvastatin
D: Pravastatin
B: Lovastatin
Which of the following drugs is metabolized primarily through glucuronidation?
A: Delavirdine
B: Nevirapine
C: Dolutegravir
D: Nelfinavir
C: Dolutegravir
Doctor Ray is SWEET
Dolutegravir, Raltegravir
HIV 13
Which of the following is a correct match of antiretroviral and corresponding side effect/adverse event?
A: stavudine - increase MCV (macrocytosis)
B: emtricitabine - skin hyperpigmentation
C: darunavir - increase total bilirubin (hyperbilirubinemia)
D: raltegravir - hepatic steatosis
B: emtricitabine - skin hyperpigmentation
Which of the following medications is NOT part of the DHHS first-line (preferred) regimen for the treatment of HIV-infected adults and adolescents?
A: Efavirenz
B: Elvitegravir
C: Etravirine
D: Emtricitabine
C: Etravirine
EXTRA - need to have had EXTRA tx experience before we start this one
