HIV

Question 1

Time to suppression after initiation of therapy

Answer 1

12-24 weeks

Question 2

NRTI elimination

Answer 2

Renal (Exception: Abacavir)

Question 3

Abacavir elimination

Answer 3

Alcohol dehydrogenase (NRTI renal exception)

Question 4

Diminished efficacy with VL >100,000

Answer 4

Abacavir

Rilpivirine

Question 5

1st Generation NNRTIs

Answer 5

Nevirapine
Efavirenz
Delavirdine

Question 6

2nd generation NNRTIs

Answer 6

Rilpivirine

Etravirine

Question 7

NNRTI Metabolism

Answer 7

CYP3A4 Inducers (Exception: Rilpivirine)

Question 8

Must take at night on an empty stomach, causes vivid dreams

Answer 8

Efavirenz

Question 9

Must take with a 500 calorie meal

Answer 9

Rilpivirine

Lopinavir/Ritonavir, Saquinavir, Tipranavir, Elvitegravir, Atazanavir taken with food

Question 10

The two pharmacokinetic boosters

Answer 10

Ritonavir

Cobicastat

Question 11

Must be boosted with Tenofovir

Answer 11

Atazanavir

Question 12

Elvitegravir metabolism

Answer 12

CYP3A4 and UGT1A1

Question 13

Only first line given BID

Answer 13

Raltegravir

Question 14

Cytidine NRTIs

Answer 14

Emtricitabine

Lamivudine

Question 15

Causes hyperpigmentation of hands & soles

Answer 15

Emtricitabine

Question 16

Guanosine NRTIs

Answer 16

Abacavir

Question 17

Adenosine NRTIs

Answer 17

TDF
TAF
Didanosine

Question 18

Thymidine NRTIs

Answer 18

Zidovudine

Stavudine

Question 19

Post-Exposure Prophylaxis (PEP)

Answer 19

(TDF + Emtricitabine) + Raltegravir or Dolutegravir