HIV

Question 1

What stage of HIV life cycle in NRTI/NNRTIs?

Answer 1

Stage 3 - Rever Transcription

Question 2

What stages of HIV life cycle in INST?

Answer 2

Stage4 - Intergration

Question 3

Stages of HIV life cycle in PIs?

Answer 3

Stage 6 - Assembly

Question 4

Stages of HIV life cycle in enfuvirtide

Answer 4

Stage 2 - Fusion

Question 5

STages of HIV life cycle in CCR5?

Answer 5

Stage 1 - binding

Question 6

Rx in CCR5?

Answer 6

Maraviroc (selzentry)
AE: URTIs/ Fever/ Rash(SJS), musculoskeletal symptoms, dizziness
monitoring: Test Trofile: tropism of HIV ; CCR5 only works on tropic disease
BW: hepatotoxic

Question 7

RX in Fusion inhibitor?

Answer 7

Enfuvirtide (Fuzeon)
AE: injection site
powder for injection

Question 8

Epzicom

Answer 8

abacavir + lamivudine

QD

Question 9

Truvada

Answer 9

Emtricitabine + tenofovir

QD

Question 10

Combivir

Answer 10

Lamivudine + Zidovudine

BID

Question 11

Trizivir

Answer 11

Abacavir + lamivudine + zidovudine

BID

Question 12

Atripla

Answer 12

Efavirenz + emtricitabine + tenofovir

QD empty stomach

Question 13

Complera

Answer 13

Emtricitabine + rilpivrine + tenofovir

QD with food

Question 14

Stribild

Answer 14

Elvitegravir + cobicistat+emtricitabine + tenofovir

QD with food

Question 15

Triumeq

Answer 15

Abacavir + dolutegravir+lamivudine

QD

Question 16

Preferred regimens for HIV pregnant woman

Answer 16

Epzicom / Truvada / Combivir

Question 17

Preferred regimen for Pre treatment HIV viral load

Answer 17

Atazanavir + ritonavir + Epzicom
Efavirenz + Epzicom
Complera

Question 18

General Preferred regimen

Answer 18

NNRTI
Atripla - CNS effects

PIs
Atazanavir + ritonavir + Truvada
Darunavir + ritonavir + Truvada

INSTIs
Dolutegravir + Epzicom
Dolutegravir + Truvada
Elvitgravir / Cobicistate/+truvada
RAltegravir + Truvada

Question 19

AE / Monitoring - Abacavir

Answer 19

Ziagen
BW - hypersensitivity RXN
HLa-B5701 allele prior
AE: n/v, HA, Rash, LFTs

Question 20

AE/monitoring - Emtricitabine

Answer 20

Emtriva
BW: exacerbate Hep B
AE: hyperpigmentation, rash, LFTs

Question 21

AE/monitoring - lamivudine

Answer 21

Epivir
BW: Epivir-HBV is not for HIV treatment
exacerbation / resistance development of HBV
AE: HA, insomnia, LFTs, rash

Question 22

TeNOFovir

Answer 22

Viread
BW: exacerbate HBV
AE: renal , Fanconi’s syndrome, osteomalacia, low bone density

Question 23

zidovudine

Answer 23

Retrovir ( only HIV IV)
BW: hematologic toxicities (neutropenia / anemia)
AE: n/v, skin/nail hyperpigmentation (BLUE), LFTs, macrocytic anemia

Question 24

Efavirenz

Answer 24

Sustiva
AE: CNS / vivid dreams / LFTs / rash
Pregnancy D

Question 25

Rilpivirine

Answer 25

Edurant
CI: all PPIs
AE: CNS HA, rash , LFTs
seperate H2RAs and Antacids 2-12 hours before / 4 hours after

Question 26

atazanavir

Answer 26

Reyataz
AE: PR interval prolongation, nephrolithiasis
monitor HEART (ECG), LFTs
seperate H2RA / Antacids / PPIs

Question 27

Darunavir

Answer 27

Prezista
Sulfa allergy
AE: SJS/TEN, LFTs, HA

Question 28

Lopinavir + ritonavir

Answer 28

Kaletra

AE: ab pain, QT prolongation, LFts,

Question 29

Ritonavir

Answer 29

Norvir
Use as booster
with food
AE: PR prolongation, Paresthesiaas