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NAPLEX > HIV > Flashcards

HIV Flashcards

1
Q

What stage of HIV life cycle in NRTI/NNRTIs?

A

Stage 3 - Rever Transcription

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2
Q

What stages of HIV life cycle in INST?

A

Stage4 - Intergration

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3
Q

Stages of HIV life cycle in PIs?

A

Stage 6 - Assembly

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4
Q

Stages of HIV life cycle in enfuvirtide

A

Stage 2 - Fusion

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5
Q

STages of HIV life cycle in CCR5?

A

Stage 1 - binding

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6
Q

Rx in CCR5?

A

Maraviroc (selzentry)
AE: URTIs/ Fever/ Rash(SJS), musculoskeletal symptoms, dizziness
monitoring: Test Trofile: tropism of HIV ; CCR5 only works on tropic disease
BW: hepatotoxic

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7
Q

RX in Fusion inhibitor?

A

Enfuvirtide (Fuzeon)
AE: injection site
powder for injection

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8
Q

Epzicom

A

abacavir + lamivudine

QD

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9
Q

Truvada

A

Emtricitabine + tenofovir

QD

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10
Q

Combivir

A

Lamivudine + Zidovudine

BID

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11
Q

Trizivir

A

Abacavir + lamivudine + zidovudine

BID

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12
Q

Atripla

A

Efavirenz + emtricitabine + tenofovir

QD empty stomach

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13
Q

Complera

A

Emtricitabine + rilpivrine + tenofovir

QD with food

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14
Q

Stribild

A

Elvitegravir + cobicistat+emtricitabine + tenofovir

QD with food

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15
Q

Triumeq

A

Abacavir + dolutegravir+lamivudine

QD

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16
Q

Preferred regimens for HIV pregnant woman

A

Epzicom / Truvada / Combivir

17
Q

Preferred regimen for Pre treatment HIV viral load

A

Atazanavir + ritonavir + Epzicom
Efavirenz + Epzicom
Complera

18
Q

General Preferred regimen

A

NNRTI
Atripla - CNS effects

PIs
Atazanavir + ritonavir + Truvada
Darunavir + ritonavir + Truvada

INSTIs
Dolutegravir + Epzicom
Dolutegravir + Truvada
Elvitgravir / Cobicistate/+truvada
RAltegravir + Truvada
19
Q

AE / Monitoring - Abacavir

A

Ziagen
BW - hypersensitivity RXN
HLa-B5701 allele prior
AE: n/v, HA, Rash, LFTs

20
Q

AE/monitoring - Emtricitabine

A

Emtriva
BW: exacerbate Hep B
AE: hyperpigmentation, rash, LFTs

21
Q

AE/monitoring - lamivudine

A

Epivir
BW: Epivir-HBV is not for HIV treatment
exacerbation / resistance development of HBV
AE: HA, insomnia, LFTs, rash

22
Q

TeNOFovir

A

Viread
BW: exacerbate HBV
AE: renal , Fanconi’s syndrome, osteomalacia, low bone density

23
Q

zidovudine

A

Retrovir ( only HIV IV)
BW: hematologic toxicities (neutropenia / anemia)
AE: n/v, skin/nail hyperpigmentation (BLUE), LFTs, macrocytic anemia

24
Q

Efavirenz

A

Sustiva
AE: CNS / vivid dreams / LFTs / rash
Pregnancy D

25
Q

Rilpivirine

A

Edurant
CI: all PPIs
AE: CNS HA, rash , LFTs
seperate H2RAs and Antacids 2-12 hours before / 4 hours after

26
Q

atazanavir

A

Reyataz
AE: PR interval prolongation, nephrolithiasis
monitor HEART (ECG), LFTs
seperate H2RA / Antacids / PPIs

27
Q

Darunavir

A

Prezista
Sulfa allergy
AE: SJS/TEN, LFTs, HA

28
Q

Lopinavir + ritonavir

A

Kaletra

AE: ab pain, QT prolongation, LFts,

29
Q

Ritonavir

A

Norvir
Use as booster
with food
AE: PR prolongation, Paresthesiaas

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