HIV Flashcards

0
Q

Clinical manifestations

A

Vague, non specific flu-like symptoms (fever, headache, malaise, fatigue, N/V, abdominal cramping
Persistent generalized lymphadenopathy-enlargement of 2 or more extrainguinal sites for more than 3 months

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1
Q

Risk factors for HIV

A
Behavior
Blood transfusions 
Health care worker
Poverty
Older age
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2
Q

Clinical manifestations of AIDS Dementia Complex

A
Fluctuating memory loss
Confusion
Difficulty concentrating 
Lethargy
Diminished motor speed
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3
Q

PCP manifestations

A
Fluctuating fever
Chills
Cough
Chest pain 
Dyspnea on exertion 
Anorexia, weight loss
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4
Q

Treatment for PCP

A

Sulfa drugs

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5
Q

Symptoms of sulfa drug allergic reactions

A

Rashes on the trunk

Really high fever (serum sickness)

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6
Q

Candidiasis manifestations

A

White, friable plaques on the tongue or. Uncalled mucosa

Difficulty swallowing

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7
Q

Mycobacterium Avium Complex manifestations

A
Chills
Fever
Weakness
Night sweats
Abdominal pain
Weight loss
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8
Q

When is an HIV pt susceptible for getting MAC

A

When CD4 falls below 50

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9
Q

Kaposi’s sarcoma manifestations

A

Vascular macules, papules, or violet lesions
Affects skin & viscera
Commonly affects face, especially tip of nose and pinnae of ears
Commonly affects GI tract, lungs, and lymphatic system

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10
Q

Treatment of Kaposi’s Sarcoma

A

Interferon alpha & Zidovudine AZT (NRTI) used in combination

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11
Q

Rapid diagnostic

A

Further testing always required

Nurse’s must prepare for immediate teaching following results

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12
Q

ELISA

A

99.5% sensitive

Detects HIV antibodies, not the virus itself

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13
Q

Western blot antibody testing

A

99.9% sensitive

More reliable, but is time consuming & expensive

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14
Q

HIV Viral load

A

Levels greater than 5,000-10,000 indicate need for treatment
Correlates disease progression and response to treatment

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15
Q

CBC

A

Used to detect anemia, leukopenia, thrombocytopenia,

Lymphopenia is especially common in HIV

16
Q

CD4 cell count

A

Monitors the disease and guides therapy

Correlates very closely with immunodeficiency disorders

17
Q

Immune complex dissociated p24 assay

A

Indicates active reproduction of HIV
Is positive before seroconversion
Useful in monitoring disease progression & antiviral activity of experimental medications

18
Q

What 4 circumstances is treatment initiated

A
  1. Symptomatic - suppress the infection
  2. Prophylaxis - CD4 below 200
  3. Stimulate hematopoietic response
  4. Treating opportunistic infections or malignancies
19
Q

NRTI

A

Zidovudine (AZT, Azidothymidine)
Didanosine (DDI, Videx)
Abacovir

20
Q

NRTI
Zidovudine (AZT, Azidothymidine)
ADMINISTRATION

A

PO 0.5 before or 1 hour after meals

Swallow capsules whole

21
Q

NRTI
Zidovudine (AZT, Azidothymidine)
ADVERSE EFFECTS

A

Nausea
Headache
Anemia
Neutropenia

22
Q

NRTI
Zidovudine (AZT, Azidothymidine)
When to notify PCP

A
Sore throat
Swollen lymph glands
Fever
Unusual fatigue or weakness
Easy bruising
Bleeding gums
Injury that will not heal 
Muscle pain or wasting
23
Q

NRTI
Didanosine (DDI, Videx)
CONTRAINDICATIONS

A

Previous pancreatitis

Kidney problems

24
Q

NRTI
Didanosine (DDI, Videx)
ADMINISTRATION

A

Tablets are chewed or dissolved in 1 oz of water
Take on empty stomach
Do not drink with alcohol

25
Q

NRTI
Didanosine (DDI, Videx)
ADVERSE EFFECTS

A

Peripheral neuropathy
Diarrhea
Depression

26
Q

NRTI
Didanosine (DDI, Videx)
Stop drug & notify PCP for

A
Pancreatitis
Hepatic failure
Extremity pain
Weakness
Numbness, or tingling
27
Q

NRTI
Abacavir
ADMINISTRATION

A

Take without regard to food or water

28
Q

NRTI
Abacavir
Nursing responsibilities

A

Assess for possible hypersensitivity reactions, anemia, neutropenia

29
Q

PI

ADVERSE EFFECTS

A

Lipodystrophy
Elevated cholesterol & triglycerides (do not treat with lovastatin or simvastatin)
Insulin resistance
Diabetes

30
Q

NNRTI

A

Nevirapine (Viramune)
Delavirdine (Rescriptor)
Efavirenz (Sustiva)

31
Q

NNRTI Nevirapine (Viramune)

A

Risk for liver toxicity

Stevens-Johnson syndrome

32
Q

Entry inhibitors action

A

Prevent HIV from entering target cells by binding to the protein envelope that surrounds the virus
Improves cd4 count & lowers viral load