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HIV > HIV > Flashcards

HIV Flashcards

1
Q

DIdanosine

A

NRTI

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2
Q

Tenofovir

A

NNRTI that is in NRTI class

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3
Q

Abacavir

A

NRTI

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4
Q

Zidovudine

A

NRTI

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5
Q

Stavudine

A

NRTI

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6
Q

Efavirenz

A

NNRTI

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7
Q

Delavirdine

A

NNRTI

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8
Q

Rilpivirine

A

NNRTI

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9
Q

Atazanavir

A

PI

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10
Q

Ritonavir

A

PI

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11
Q

Daranavir

A

PI

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12
Q

Maraviroc

A

Entry Inhibitor

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13
Q

Enfuvirtide

A

Fusion Inhibitor

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14
Q

Raltegravir

A

Integrase Inhibitor

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15
Q

Elvitegravir

A

Integrase Inhibitor

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16
Q

Dolutegravir

A

Integrase Inhibitor

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17
Q

Calbicistat

A

Pharmacoenhancer

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18
Q

Also pharmacoenhancer

A

Ritonavir

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19
Q

Didanosine + Tenofovir

A

Dec. CD4 paridoxically

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20
Q

EtOH + Abacavir

A

Inc. conc. Abacavir

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21
Q

Ribavirin + Didanosine

A

Fulmainant hepatic failure

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22
Q

Zidovudine + Stavudine

A

Antagonism (never see Stavudine due to toxicity)

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23
Q

Tenofovir + Atazanavir

A

Must be given with Ritonavir (T dec. A leading to PI resistance, A inc. T)

24
Q

Atazanavir + PPI

A

DI

25
Q

CYP with NRTIs?

A

NO

26
Q

CYP with NNRTIs?

A

Hard to predict (INDUCTION or inhibition)

27
Q

Most unpredictable NNRTI CYP interaction

A

EFAVIRENZ and Nevirapine

28
Q

Rilpivirine + PPI

A

CI (requires acidic pH)

29
Q

Warfarin + NNRTIs

A

inhibition/induction = monitor

30
Q

Clarithromycin + NNRTIs

A

induction = dec. effects (use Azith)

31
Q

Statins + NNRTIs

A

induction - dec. effects

32
Q

PDE#s + NNRTIs

A

Less dangerous, titrate to effect of PDE#

33
Q

CYP with PIs?

A

INHIBITION or induction

34
Q

Warfarin + PIs

A

monitor closely

35
Q

Voriconazole + Ritonavir

A

inhibition = dec. vori effects

36
Q

BZDs + PIs

A

For intubation ok to use one time dose of midazolam or triazolam (short acting), ok to use LOT (no CYP)

37
Q

Colchicine + PIs

A

Not recommended if renal/hepatic impairment and on PI

38
Q

Statins + PIs

A

inhibition = inc. effects statins (Atorvastatin 10 = 40), Pravastatin is safest to use

39
Q

St. John’s Wort + PIs

A

Dec. PI effects

40
Q

PDE#s + PIs

A

Inc. effects of PDE# = risk of priapism

41
Q

Advair + PIs

A

Fluticasone = steroid overload (use Beclamethasone instead), Salmeterol = increased risk of QT prolongation

42
Q

Clarithromycin + PIs

A

Inc risk of metallic taste and GI effects due to inc. conc of Clarithromycin

43
Q

Maraviroc + CYP drugs

A

CYP interactions

44
Q

Enfuviritide DIs

A

NONE

45
Q

Raltegravir dosing

A

BID (first line)

46
Q

Elvitegravir/calbicistat dosing

A

QD (first line)

47
Q

Do not eat with…

A

Efavirenz

48
Q

Dolutegravir dosing

A

QD (first line)

49
Q

Dolutegravir DIs

A

Don’t use with drugs that do not undergo CYP: CBZ, Phenytoin, Oxcarb, Rifampin

50
Q

Nafcillin + Warfarin

A

Dec. INR

51
Q

Warfarin + FAB 5

A

Flucon, FQs, Flagyl, Amio, Bactrim

52
Q

ABX + OCs

A

Rifampin will lower OC conc., Bactrim will inc

53
Q

Dapto + Statins

A

Risk of rhabdo (inc. risk of AE, not DI)

54
Q

FQs/Tets + Multivalent Cations

A

Space out by 4 hours if possible

55
Q

Eat with…

A

Rilpivirine (full meal), Elivitagrivir

HIV (1 decks)

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