HIV Flashcards
1
Q
DIdanosine
A
NRTI
2
Q
Tenofovir
A
NNRTI that is in NRTI class
3
Q
Abacavir
A
NRTI
4
Q
Zidovudine
A
NRTI
5
Q
Stavudine
A
NRTI
6
Q
Efavirenz
A
NNRTI
7
Q
Delavirdine
A
NNRTI
8
Q
Rilpivirine
A
NNRTI
9
Q
Atazanavir
A
PI
10
Q
Ritonavir
A
PI
11
Q
Daranavir
A
PI
12
Q
Maraviroc
A
Entry Inhibitor
13
Q
Enfuvirtide
A
Fusion Inhibitor
14
Q
Raltegravir
A
Integrase Inhibitor
15
Q
Elvitegravir
A
Integrase Inhibitor
16
Q
Dolutegravir
A
Integrase Inhibitor
17
Q
Calbicistat
A
Pharmacoenhancer
18
Q
Also pharmacoenhancer
A
Ritonavir
19
Q
Didanosine + Tenofovir
A
Dec. CD4 paridoxically
20
Q
EtOH + Abacavir
A
Inc. conc. Abacavir
21
Q
Ribavirin + Didanosine
A
Fulmainant hepatic failure
22
Q
Zidovudine + Stavudine
A
Antagonism (never see Stavudine due to toxicity)
23
Q
Tenofovir + Atazanavir
A
Must be given with Ritonavir (T dec. A leading to PI resistance, A inc. T)
24
Q
Atazanavir + PPI
A
DI
25
CYP with NRTIs?
NO
26
CYP with NNRTIs?
Hard to predict (INDUCTION or inhibition)
27
Most unpredictable NNRTI CYP interaction
EFAVIRENZ and Nevirapine
28
Rilpivirine + PPI
CI (requires acidic pH)
29
Warfarin + NNRTIs
inhibition/induction = monitor
30
Clarithromycin + NNRTIs
induction = dec. effects (use Azith)
31
Statins + NNRTIs
induction - dec. effects
32
PDE#s + NNRTIs
Less dangerous, titrate to effect of PDE#
33
CYP with PIs?
INHIBITION or induction
34
Warfarin + PIs
monitor closely
35
Voriconazole + Ritonavir
inhibition = dec. vori effects
36
BZDs + PIs
For intubation ok to use one time dose of midazolam or triazolam (short acting), ok to use LOT (no CYP)
37
Colchicine + PIs
Not recommended if renal/hepatic impairment and on PI
38
Statins + PIs
inhibition = inc. effects statins (Atorvastatin 10 = 40), Pravastatin is safest to use
39
St. John's Wort + PIs
Dec. PI effects
40
PDE#s + PIs
Inc. effects of PDE# = risk of priapism
41
Advair + PIs
Fluticasone = steroid overload (use Beclamethasone instead), Salmeterol = increased risk of QT prolongation
42
Clarithromycin + PIs
Inc risk of metallic taste and GI effects due to inc. conc of Clarithromycin
43
Maraviroc + CYP drugs
CYP interactions
44
Enfuviritide DIs
NONE
45
Raltegravir dosing
BID (first line)
46
Elvitegravir/calbicistat dosing
QD (first line)
47
Do not eat with...
Efavirenz
48
Dolutegravir dosing
QD (first line)
49
Dolutegravir DIs
Don't use with drugs that do not undergo CYP: CBZ, Phenytoin, Oxcarb, Rifampin
50
Nafcillin + Warfarin
Dec. INR
51
Warfarin + FAB 5
Flucon, FQs, Flagyl, Amio, Bactrim
52
ABX + OCs
Rifampin will lower OC conc., Bactrim will inc
53
Dapto + Statins
Risk of rhabdo (inc. risk of AE, not DI)
54
FQs/Tets + Multivalent Cations
Space out by 4 hours if possible
55
Eat with...
Rilpivirine (full meal), Elivitagrivir
