HIV

Question 1

Which combos work better?

Answer 1

Tenofovir and emtricitabine

Abacavir and lamivudine

Question 2

Side effects of NRTI

Answer 2

Mitochondrial toxicity
- NRTI are more selective for HIV RT than human DNA polymerase
- Anemia, granulocytosis, peripheral neuropathy, lactic acidosis, myopathy, hepatic stenosis
- Lipoatrophy

Abacavir hypersensitivity–>black box
-malaise, headache dizziness, GI, DC if develop
Test for HLA-B*5701 before treatment

Question 3

Resistance of NNRTI

Answer 3

1 single mutation in binding site can lead to resistance