HIV Flashcards
When does AIDs occur after infection with HIV?
When CD4 cells fall below 200 cells/microlitre
How do you treat AIDs in treatment naive patients?
Triple therapy!
Two nucleoside reverse transcriptase inhibitors (NRTIs) as a backbone: emtricitabine and either tenofovir disoproxil or tenofovir alafenamide (OR) abacavir and lamivudine
Third drug (one of the following): ritonavir-boosted azanavir, ritonavir-boosted darunavir, dolutegravir, cobicistat-boosted elvitegravir, raltegravir, rilpivirine, efavirenz
How do you treat AIDs and hepatitis B?
Tenofovir disoproxil and emtricitabine (OR)
Tenofovir alafenamide and emtricitabine
How do you treat AIDs in pregnancy?
First and second drug: Tenofovir disoproxil or abacavir with either emticitabine or lamivudine
Third drug: efavirenz or ritonavir-boosted atazanavir.
What are pharmacokinetic enhancers that can be used when treating for AIDs?
Cobicistat and low-dose ritonavir
What are special precautions for use with dolutegravir?
It should not be used in pregnancy or in women of childbearing potential due to the risk of neural tube defects.
Development of osteonecrosis and/or hypersensitivity (raised liver enzymes, angioedema, conjunctivitis, arthralgia, fever, oral lesions, rash)
What are special precautions for use for elvitegravir boosted with cobicistat?
Exposure is lower during second and third trimesters of pregnancy therefore increased risk of treatment failure and increased risk of HIV-1 transmission to the unborn child.
