HIV

Question 1

Which HIV subtype is prevalent in the world?

Answer 1

HIV 1

Question 2

Fusion envelope protein of HIV

Answer 2

gp 41

Question 3

Shape of nucleocapsid of HIV

Answer 3

icosahedral

Question 4

gp 120 bind to_ receptors

Answer 4

CD4 and chemokine receptor

Question 5

Drug that inhibits binding of gp120 to CCR4

Answer 5

Maraviroc

Question 6

Drug that inhibits gp 41

Answer 6

Enfuvirtide

Question 7

gene coding for gp 120 and gp 41

Answer 7

env gene

Question 8

Name CD4 positive cells

Answer 8

T cell
Monocytes
Macrophages
Langerhans cells
Microglial cell
Dendritic cells in lymph nodes and spleen

Question 9

Matrix protein of HIV

Answer 9

p17

Question 10

gene coding for reverse transcriptase, integrase and protease in HIV

Answer 10

pol gene

Question 11

Name anti-retroviral drugs that can cause skin rash and Steves Johnsons syndrome

Answer 11

Nevirapine

Efavirenz

Question 12

During acute phase of HIV infection

Answer 12

Viremia is present
Antibodies are not significant to be detected
Fever, fatigue, weigh loss, CD4 counts are normal

Question 13

Clad E is caused by

Answer 13

heterosexual sex

Question 14

Clad B

Answer 14

homosexual(male sex)

Question 15

Two drugs that are always present in HAART regimens

Answer 15

Emtricitabine

Tinofovir

Question 16

Nef protein inhibits synthesis of

Answer 16

MHC class 1

Question 17

Tat gene

Answer 17

enhances viral transcription

Question 18

Regulatory genes in HIV

Answer 18

Tat
Rev (brings mRNA rapidly into cytoplasm)
Vif (destroys APOBEC3G= Viral infectivity factor)
VPR (inc. replication)
VPU (inc. release)
Nef

Question 19

APOBEC3G

Answer 19

causes hyper-mutation in HIV