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Timeline Of Immuno Sero > History Of Immuno Sero > Flashcards

History Of Immuno Sero Flashcards

0
Q

Recognition of “adaptive” protection against disease

A

Egypt & China

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1
Q

Fever

A

Mesopotamia

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2
Q

Anatomic identification of organs

A

Hippocrates

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3
Q

Acquired resistance to poisons

A

Mithridate Eupator, King of Pontus

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4
Q

Four cardinal signs of inflammation

A

Celsus

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5
Q

“Snuff” variolation for smallpox

A

Sung Dynasty, China

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6
Q

Bursa of birds described

A

Fabricius

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7
Q

Lymphoid tissue identified in small intestine

A

Peyer

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8
Q

Observed the positive effects of variolation on the native population and had the technique performed on her own children.

A

Lady Mary Wortley Montagu

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9
Q

First demonstration of vaccination (smallpox vaccination)

A

Edward Jenner

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10
Q

First description of the role of microbes in putrefaction and fermentation

A

Theodore Schwann

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11
Q

Confirmation of the role of yeast in fermentation of sugar to alcohol

A

Charles Cagniard-Latour

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12
Q

First “modern” proposal of the germ theory of disease

A

Jacob Henley

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13
Q

Demonstration of the contagious nature of puerperal fever (childbed fever)

A

Ignaz Semmelweis

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14
Q

Tuberculous granulomas

A

Rokitansky

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15
Q

Langhans Giant Cells

A

Langhans

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16
Q

Confirmation of the role of microbes in fermentation

A

Louis Pasteur

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17
Q

Theory that bacterial virulence could be attenuated by culture in vitro and used as vaccines. Proposed that live attenuated microbes produced immunity by depleting host of vital trace nutrients.

A

Louis Pasteur

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18
Q

Phagocytosis

A

Ernst Haeckel

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19
Q

First aseptic practice in surgery using carbolic acid

A

Joseph Lister

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20
Q

First demonstration that microbes can cause disease ANThrax

A

Robert Koch

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21
Q

Mast Cells

A

Paul Ehrlich

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22
Q

Confirmation and popularization of the germ theory of disease

A

Louis Pasteur

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23
Q

Birth of cellular pathology

A

Virchow

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24
Q

Cellular theory of immunity via phagocytosis by macrophage and microphages (polymorphonuclear leukocytes)

A

Elie Metchnikoff

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25
Q

Introduction of the concept of “therapeutic vaccination”.

A

Louis Pasteur

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26
Q

Anti-rattlesnake venom discovered

A

Sewall

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27
Q

Identification of bacterial toxins (Diptheria bacillus)

A

Pierre Roux and Alexandre Yersin

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28
Q

Bactericidal action of blood

A

George Nuttall

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29
Q

Demonstration of antibody activity against diphtheria and tetanus toxins. Beginning of humoral theory of immunity.

A

Emil von Behring and Shibasaburo Kitasato

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30
Q

Demonstration of cutaneous (delayed type) hypersensitivity

A

Robert Koch

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31
Q

Use of live bacteria and bacterial lysates to treat tumors (Coley’s Toxins)

A

William B. Coley

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32
Q

Bacteriolysis

A

Richard Pfeiffer

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33
Q

An antibacterial, heat-labile serum component (complement) is described

A

Jules Bordet

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34
Q

Antibody formation theory “side chain theory” “horror autotoxicus”

A

Paul Ehrlich

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35
Q

Blood groups

A

Karl Landsteiner

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36
Q

Transplantable tumors

A

Carl Jensen and Leo Loeb

37
Q

Immediate hypersensitivity (anaphylaxis)

A

Paul Portier and Charles Richet

38
Q

Intermediate hypersensitivity, the “Arthus reaction”

A

Maurice Arthus

39
Q

Opsonization

A

Almroth Wright & Stewart Douglas

40
Q

“Serum sickness” allergy

A

Clemens Von Pirquet and Bela Schick

41
Q

Successful organ transplantation

A

Correl and Guthrie

42
Q

Coined the word “allergy”

A

Clemens Von Pirquet

43
Q

Coined the term “immunochemistry”

A

Svante Arrhenius

44
Q

Inheritance of ABO blood groups

A

Emil von Dungern & Ludwik Hirzfeld

45
Q

Viral immunology theory

A

Peyton Rous

46
Q

2nd demonstration of filterable agent that caused tumors

A

Peyton Rous

47
Q

Genetics theory of tumor transplantation

A

Clarence Little

48
Q

Inbred Mouse Strains

A

Clarence Little and Leonell Strong

49
Q

Hapten

A

Karl Landsteiner

50
Q

Cutaneous Allergic Reactions

A

Carl Prausnitz and Heinz Kustner

51
Q

Found lysozyme and penicillin

A

Alexander Fleming

52
Q

Reticuloendothelial system

A

Aschoff

53
Q

Chemical mediators of inflammation

A

Lewis

54
Q

Isolation of pure antibody preparation

A

Lloyd Felton and GH Bailey

55
Q

Quantitative precipitin reaction

A

Heidelberger

56
Q

Identification of the H-2 antigen in mice

A

Peter Gorer

57
Q

Identified Gammaglobulin

A

Tiselius and Kabat

58
Q

Antigen-Antibody binding hypothesis

A

John Marrack

59
Q

Identification of the Rh antigens

A

Karl Leindsteiner & Alexander Weiner

60
Q

Hemolytic disease of the newborn (Rh antigens)

A

Philip Levine

61
Q

Immunoflourescence technique

A

Albert Coons

62
Q

Anaphylaxis

A

Karl Landsteiner and Merill Chase

63
Q

Adjuvants

A

Jules Freund and Katherine McDermott

64
Q

Hypothesis of Allograft rejection

A

Peter Medawar

65
Q

Passive transfer of cell mediated immunity

A

Merill Chase

66
Q

Identification of mouse MHC (H2)

A

George Snell & Peter A. Gorer

67
Q

Twins do not demonstrate transplant rejection

A

Owen

68
Q

Antibody production in plasma B cells

A

Astrid Fagraeus

69
Q

Growth of polio virus in tissue culture, neutralization with immune sera, and demonstration of attenuation of neurovirulence with repetitive passage

A

John Enders, Thomas Weller, Frederick Robbins

70
Q

Immunological tolerance hypothesis

A

Macfarlane Burnet & Frank Fenner

71
Q

Discovery of Suppressor T cells

A

Richard Gershon and K Kondo

72
Q

Discover of agammagobulinemia (antibody immunodeficiency)

A

Ogden and Bruton

73
Q

Vaccine against yellow fever

A

1951

74
Q

Graft vs. Host disease

A

Morton Simonsen and WJ Dempster

75
Q

Immunological tolerance hypothesis

A

Rupert Billingham, Leslie Brent, Peter Madawar, Milan Hasek

76
Q

Discovery of histamine in mast cells

A

James Riley and Geoffrey West

77
Q

Clonal Selection Theory

A

Niels Jerne, David Talmage, Macfarlane Burnet

78
Q

Discovery of interferon

A

Alick Isaacs and Jean Lindermann

79
Q

Induction of auto immunity in animals

A

Ernest Witbsky et al

80
Q

Discovery of human leukocyte antigens

A

Jean Dausset and Snell

81
Q

Discovery of antibody structure

A

Gerald Edelman and Rodney Porter

82
Q

Discovery of lymphocyte circulation

A

James Gowans

83
Q

Discovery of lymphocyte “blastogenic transformation” and proliferation in response to mitogenic lectins-phytohemagglutinin (PHA)

A

Peter Nowell

84
Q

Discovery of thymus involvement in cellular immunity

A

Jacques Miller

85
Q

Demonstration that glucocorticoids inhibit PHA-induced lymphocyte proliferation

A

Peter Nowell

86
Q

Classification of immune mechanism

A

Gel and Coombs

87
Q

Development of the plaque assay for the enumeration of antibody-forming cells in vitro

A

Niels Jerne & Albert Nordin

88
Q

Antibody idiotypes

A

Jaques Odin et al

89
Q

T and B cell cooperation in immune response

A

Anthony Davis

90
Q

Mixed lymphocyte reaction

A

Bain, Vas et al

Timeline Of Immuno Sero (1 decks)

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