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ImmunoSero > History > Flashcards

History Flashcards

1
Q

Father of Immunology

A

Louis Pasteur

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2
Q

Introduced HIV

A

Montagner and Sinoussi

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3
Q

1st blood transfused

A

Pope Innocent VII

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4
Q

T cell receptor gene discovery (year)

A

1984

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5
Q

Bacteria with No cell wall

A

Mycoplasma & Ureaplasma

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6
Q

Phagocytosis

A

Initiation (CR3)
Chemotaxis (C5a)
Engulfment (C3b)
Digestion (Ureaplasma)

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7
Q

Test for Chemotaxis

A

Boyden Chamber Assay

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8
Q

Cachectin by Macrophages

A

TNF-alpha

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9
Q

Causes meningitis

A

H.influenzae
N.meningitidis
S.pneumoniae

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10
Q

CGD

A

failure of Neutrophils to produce O2

(-) NADPH Oxidase

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11
Q

CGD Test

A

NBT Dye test

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12
Q

CGD blood component

A

Granulocyte concentration

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13
Q

Complement activation

A

C142356789

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14
Q

Receptor for EBV

A

CD21

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15
Q

Have IgD on surface

A

Mature B cells

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16
Q

Discovered 1st in Bursa of Fabricius in Birds

A

B cell

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17
Q

Identified by E-Rosette

A

T cell

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18
Q

HLA can be found on

A

Chromosome 6 (short arm)

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19
Q

Most efficient APR

A

Dendritic cells

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20
Q

A potent antigen has a weight of

A

> 10 kDa

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21
Q

Most immynogenic graft

A

BM

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22
Q

Least immunogenic graft

A

Cornea

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23
Q

Most acceotable theory

A

Clonal selection theory

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24
Q

Best to cross placenta

A

IgG1

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25
Q

Don’t cross the placenta

A

IgG2

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26
Q

Best to fix complement

A

IgM

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27
Q

IgM

A

Agglutination

28
Q

IgG

A

Precipitation

29
Q

Antigen-antibody complexes

A

Classical pathway

30
Q

Microorganism’s mannose

A

Lectin pathway

31
Q

Most severe

A

C2 deficiency

32
Q

Most common deficiency

A

C2 deficiency

33
Q

Hutchinsonian triad can be found in

A

Congenital syphilis

34
Q

Hutchinsonian triad consists of

A

Keratitis
Notched teeth
Deafness

35
Q

Primary syphilis symptom

A

Hard chancre

Dx: dark field

36
Q

Secondary syphilis

A

Condylomata lata

Dx: Dark field, serologic test

37
Q

Latent stage

A

Asymptomatic

Dx: serologic

38
Q

Tertiary syphilis

A

Gummas (found treponemes)

Dx: serologic

39
Q

Serologic tests for Syphilis

A

Wasserman test : C’ fixation
Nontreponemal serologic: VDRL, RPR
Treponemal serologic: TPI, FTA-ABS, TPHA, MHA-TP, HATTS)

40
Q

Gold standard syphilis test

A

FTA-ABS

41
Q

ASO is reported in what units

A

Todd units

NV: 0-166

42
Q

Dane particle

A

Hepatatis B

43
Q

Major cause of post transfusion Hepatitis

A

Heoatitis C

44
Q

Coinfection hepatitis

A

Hepatitis D with Hepa B

45
Q

Australia antigen

A

HBsAg

1st marker to appear

46
Q

High vertical transmission

A

HBeAg

47
Q

NOT a serologic marker

A

HBcAg

48
Q

1st Antibidy produced

A

IgM anti-HBc

49
Q

Total anti-HBc

A

Lifelong marker

50
Q

Core window

A

IgM anti-HBc

51
Q

Lifelong marker hepatitis

A

Total anti-HBc

52
Q

Convalescence marker

A

Anti-HBc

53
Q

HBsAg test

A 
1st gen. Test: ouchterlony double diffusion 
2nd gen test: counterelectrophoresis
Rheophoresis
C' fixation
3rd gen test: RIA, ELISA, RPHA, RPKA
54
Q

HIV envelope gene

A

gp160, gp120, gp41

55
Q

Gag genes

A

p55, p15, p17, p24

56
Q

First antibody to appear in HIV infection

A

p24

57
Q

HIV Screening

A

ELISA (standard)
Agglutination
Dot-Blot

58
Q

HIV Confirmatory

A 
Western blot (gold standard)
Immunofluorescence assay
59
Q

RA Tests

A

Rose-Waaler test (sheep cell)

Singer-plotz test (latex fixation)

60
Q

Infectious mononucleosis

A

EBV

61
Q

Test for IM

A

Paul-Bunnell Screening test

Davidson differential test

62
Q

Forssman antigen

A

Infectious mononucleosis

63
Q

Widal test is for

A

S. Typhi

64
Q

Weil-Felix test

A

Rickettsii

65
Q

Cook who became famous because of carrier of febrile disease who killed 50% persons

A

Mary Mallon

ImmunoSero (1 decks)

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