Histories Flashcards

1
Q

LUTS

A

Differentials:
Infective - UTI/prostatitis/in setting of stone
Benign - BPH/Stricture, constipation, Medications (Diuretics), Diabetes insipidus
Malignant - Prostate cancer / Bladder cancer (primarily trigone lesions)
Neurological - MS/Parkinson’s

History questions:
Storage
- If frequency - caffeine + water intake
Voiding
Acuity of symptoms
Dysuria/Flank pain
Fevers/Rigors/Sweats
Haematuria
- If yes –> smoking, occupational exposures, past pelvic radiotherapy
FmHx urological/breast/ovarian, bony pain, fatigue
Altered bowel habit
New medications, recent surgery
Any new weakness / change in sensation / parasthesia’s / PmHx/FmHx neurological disease or Diabetes
Previous UTI’s / Previous pelvic trauma / Previous STI’s

Investigations:
Bedside - urine dipstick, DRE, PVR, uroflow, Bladder diary
Urine MCS
Lab - PSA (if no concern of infection), FBC, Coags (if haematuria), eGFR (determine whether can do CT IVP if haematuria), CRP (if concern of infection)
Imaging - RTUS to size prostate vs CT non-con/IVP depending on Hx, MRI prostate

Treatment
Abx - 4 weeks cipro for prostatitis, 7/7 for UTI in male
Medical management - Duodart vs Tamsulosin (if concern for ED)
Operation
- Consider flexi if haematuria/microhaematuria or significant symptoms of urgency/UUI w/ risk factors of TCC (suggestive of trigonal tumour) or as part of UTI workup for younger male or if concern that there is a stricture (can also do RGUG in this case).
- Consider TURP/GLL/HOLEP/Urolift if refractory to medical management / patient preference (urolift doesn’t have retrograde ejaculation)
- TP Biopsy –> PSMA PET –> prostatectomy vs EBRT vs active surveillance vs watchful waiting vs ADT + novel hormonal agent

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2
Q

Headache/SAH
- Sudden collapsed, headache + vomiting in 31M

A

Differentials:
Intracerebral haemorrhage 2ndary to AVM, hypertensive haemorrhage, trauma
Intracranial infection - Meningitis,
Venous sinus thrombosis

Other things but not this situation:
Tumour
Carotid/Vertebral artery dissection
Giant cell arteritis - Temporal artery
Other benign causes of headache -

History:
SOCRATES
Acuity of onset of symptoms
Trigger of symptoms - before, during, after
Signs of meningism - neck stiffness, photophobia
Trauma -
Visual disturbances - brainstem compression
Weaknesses / sensory changes
Fevers/rigors/sweats
Hx of smoking / drug use / aneurysm / seizures
FmHx/PHx connective tissue disorder / PCKD
Vaccinations - meningitis/covid (venous sinus thrombosis)
Recent surgery / medical presentation / immunosuppression

Exam:
Vitals
Consciousness
GCS
Head trauma
Cranial nerve - pupillary size + reactivity + EOM –> brainstem compression
Signs of meningeal irritation
Limb weakness / sensory changes - Full neurological

Treatment:
Endovascular coiling vs Craniotomy + surgical clipping
- Coiling more favourable with narrow neck
- Coiling more favourable for posterior circulation aneurysms as difficult to access
- Coiling more favourable when active vasospasm and swelling (retracting hazardous)

Risk of vasospasm for 3 weeks following aneurysm (peaks at 7-10)
- Electrolytes, no medical complications etc. important
- Give nimodipine as per local guidelines

CSW syndrome vs SIADH
- CSW –> ANP –> reduced urinary sodium + water through kidneys (Urine Na&raquo_space;> Normal in CSF AND evidence of clinical and biochemical hypovolaemia (CVP and HCT)

CSW –> sodium and volume replacement
SIADH –> Fluid restriction

If in doubt better to treat as per CSW

Risk factors:
Prior aneurysm, smoking, cocaine, HTN, FmHx aneurysms and connective tissue disorder (e.g. Marfan)

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3
Q

Neck Lump
- 58M with 6/12 hx of neck swelling (not painful)

A

This one likely thyroid as elevates on swallowing (thyroid swellings elevate because they are enveloped by pretracheal fascia which attaches thyroid to laryngopharynx)

Thyroid Ddx:
MNG - colloid, hyperplastic, adenomatous)
Solitary nodule
- Cystic degeneration colloid
- Follicular adenoma
- Thyroid carcinoma - papillary/follicular/medullary/anaplastic
- Focal area of nodularity within Hashimoto’s

Other Ddx:
Infective
- Reactive lymphadenopathy – increase in size of the cervical lymph nodes in response to infection
- Sialadenitis
Neoplastic
- Lymphoma – a haematological malignancy that commonly causes lymphadenopathy
- Head and Neck Cancer or Salivary Gland Tumour
- Metastatic disease spread
- Skin lump, ranging from benign (e.g. lipoma) to malignant (skin cancer)
Vascular - Carotid body tumour (see below)
Inflammatory - Sarcoidosis
Traumatic - Haematoma
Autoimmune - Thyroid disease, such as Graves’ disease
Congenital
- Cystic hygroma (see below)
- Thyroglossal cyst (see below)
- Branchial cyst (see below)
- Dermoid cyst – a cystic type teratoma, form along the lines of embryological fusion, can present as midline painless lumps, more common in children and young adults

History:
SOCRATES
Duration of onset
How it has changed over time and recently
Painful/painless
Precipitating factors - recent infection
Lumps or bumps elsewhere
Dysphagia/dysphonia/dyspnoea/noisy breathing/hoarseness/haemoptysis
Fevers/rigors/sweats/unintentional loss of weight
Signs of thyroid - temperature, bowels, periods, appetite, weight gain vs loss
- HYPER - Appetite, weight loss, palpitations, bowel habit (diarrhoea), heat intolerance, tremor, nervousness, muscle weakness, anxiety, sweating
- HYPO - Cold intolerance, constipation, tiredness, poor appetite, weight gain, forgetfulness, dryness of skin, menorrhagia, anaemia, carpal tunnel
Opthalmic history - diplopia and grittiness
Smoker/alcohol/FmHx head and neck cancer/Radiation exposure (ionising radiation for acne, tonsillitis, excessive facial hair, thymic enlargement)
Immunosuppressive conditions
Change in bowel habit / nausea / vomiting

OE:
ENT
Cranial nerves
Thyroid (front, laterally and behind)
- Thrill/bruit
- Venous distension
- Pemberton + Horner
- How does it move withs wallowing
- Diffuse goitre or one side
- How does thyroid feel
- Tracheal deviation
- Lymphadenopathy
- Retrosternal extension
- Stigmata of thyroid disease
- Assess swallowing, cough, phonation
Rest of body - proximal myopathy, pre-tibial myxoedema, carpal tunnel, reflexes, thyroid acropathy, thyroid eye exam (ophthalmoplegia, lid lag, proptosis, exophthalmos, chemosis, conjunctivitis)

Ix:
TFT - TSH, T4
Thyroid anti-bodies - Thyroid peroxidase, Anti-thyroglobulin, TSH receptor antibodies
CMP
Nuclear scanning of thyroid nodule - limited role
USS +/- FNA (low false negative for FNA, non-diagnostic 5-10%)
- Irregular margin, micro-calcification, solid rather than cystic, vascularity centrally
- Lymph nodes

If FNA shows follicular lesions that are indeterminate –> hemithyroidectomy for tissue diagnosis –> proceed to total if required (10-20% malignant from tissue diagnosis)

If papillary or medullary –> total thyroidectomy w radioactive iodine ablation and suppressive thyroxine (most tumours are TSH dependent)

Risks
- Bleeding, infection, pain
- Damage to RLN, EBSLN, trachea
- Hypocalcaemia rare (2 functioning glands in each side of neck)

Prognosis
- Follicular 85% 10 year survival - check with nuclear scanning, USS, and Thyroglobulin levels
- Papillary -
- Anaplastic -
- Medullary -

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4
Q

NOF

  • 85yo post fall
A

Ddx:
Fracture - pelvis or hip
Haematoma alone
Muscle tear
Ligament / tendone
Intra-abdominal

History:
SOCRATES
MIST
Before, during, after
- Rule out cardiac causes if required
Loss of consciousness / head strike
Able to mobilise after
Cuts - tetanus
Any witnesses
Previous injuries to that area
Other injuries or places where it hurts
Any recent illnesses
Change in neurology
PmHx - OP, cancer, etc.
Fasting

Ix:
CT

Tx:
Fascia-iliaca / femoral nerve block
Analgesia - multi-modal
Usually operative management - arthroplasty
Delirium preventative measures
Laxatives

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5
Q

RLQ Pain

A

Ddx:
Bowel - Meckel’s, Appendicitis, malignancy constipation, IBD, hernia, bowel obstruction, ileitis
Gallbladder/Liver possible
Urinary- Renal colic, other kidney pathologies
Gynae - Ovarian cyst rupture, ectopic pregnancy, other gynae pathology
Vascular - Mesenteric infarct
MSK - Abdominal strain
Other - mesenteric adenitis

Hx:
For each of the systems as above

Ix:
Beta-HCG, urine dipstick + MCS
Bloods - FBC, UEC, CRP, LFT
CT -

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6
Q

Portal Hypertension

A

Portal hypertension DDx
Liver related:
Pre-hepatic - Right sided heart failure, constrictive pericarditis
Hepatic - Cirrhosis vs non cirrhosis causes (schistosomiasis, sarcoid, granulomatous), Portal vein thrombosis, Budd-Chiari
Post-hepatic - Splenic vein thrombosis, biliary pathology

Systemic related:
Coagulopathy
Drugs
Nodular hyperplasia

Hx:
SOCRATES
Acute vs chronic
Yellowing of skin and eyes
Encephalopathy, infection, vomiting blood
Swelling in legs or tummy
Easy bruising or bleeding
Unintentional weight loss
Fevers/rigors/sweats
FmHx liver disease/clotting issues
Full after eating
Alcohol, hepatitis, autoimmune disease, fatty liver, iron, copper
Travel/Live to Africa or recent other travel
Issues with heart
Sexual and drug history

Ix:
FBC, UEC, CRP, LFT, Coag - could consider thrombophilia panel, could also consider AFP
Need USS
CT may be required
EUS or MRI

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7
Q

AAA

A

Pain, hypotension, pulsatile mass

Ddx:
Renal colic
diverticulitis
bowel ischaemia
Degenerative disc disease
Ovarian torsion

Abdominal / back pain - pain radiating to back
- How long for
- Any sudden change
Any evidence of leg pain on walking distances
Ulcers / infections / blockages on legs
Hx of hypertension, smoking, FmHx of aneurysm, lipids, diabetes
Marfan’s, ehler’s danlos - joint dislocations, hyperextensivity, issues with eyes, collapsed lung
Other vascular - heart disease, carotid disease etc.
Previous staph, syphilis infections

Think about AMPLE

Exam:
Looking for marfanoid appearance, pulsating abdomen, obviously ischaemic legs, sweating, pain
Observations - would want to make sure not in shock
Go straight to abdomen - will do rest of body after
Inspect - no pulsatile mass
General palpation
Two hands to see if can palpate in inspiration if fat for the aorta
Then do aorta and iliac bruits
Going to legs then heart and face
Femoral artery palpation, popliteal, DP, PT, CRT, observe for any ischaemic ulcers, make sure nil stigmata distal emboli
Heart , pectus excavatum/carinatum
Neck - carotid, carotid bruit

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7
Q

Ischaemic limb:

A

Ddx
Vascular causes
ALI - embolisim, thrombosis, trauma
CLI - atherosclerosis, vasculitis, vasculopathy from radiation

Non-vascular causes
Compartment syndrome
Nec fasc / cellulitis
DVT causing venous gangrene
Spinal cord pathology
Vasospastic disorder
Cold exposure / frostbite
Gout
Septic arthritis

Hx:
Pain where
Any other regions
Is it on walking and relieved by rest
How long walking
Any night pain, specifically anything that wakes you up from sleep
- If calf pain but no foot pain potentially not ischaemic pain (worst supplied regions should be painful)
If night pain - relieved by standing up and going for walk or hanging leg off bed
Any fevers/rigors/sweats
Any smoking history
Diabetes, lipids, HTN, heart disease/stroke
Pax FmHx - renal failure, hypothyroidism, gout
Other medical conditions
Anaesthetic history
Drug history and allergies
Social history - related to rehab

Ask questions about neurological causes
Ask about mechanical causes

EXAMINE + ABI of not CLI

Ix:
BSL at bedside, prudent ECG as well if vasculopathic
FBC, UEC, CRP, Coag
CT angiography / Doppler USS / Angiogram+/-plasty

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7
Q

Groin lump

A

Should The Children Ever Find Lumps Readily

Size/site/shape/surface/skin changes/symmetry/scars
Temperature/tenderness/transillumanability
Colour/Consistency/Compressibility
Edge/Expansility and pulsatility
Fluctuation/Flud thrill/Fixation
Lymph nodes/Lumps elsewhere
Resonance/Relations/Neurovascular status

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8
Q

Ambulance Handover

A

IMIST + AMPLE

Identity of patient
Mechanism and time
- speed, what hit, anyone else
Injuries
Signs and symptoms and how they are faring
- A, B, C, D, all obs
- Any LOC, self-extrication, walking on scene
Treatment they have done

AMPLE / AMBO

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9
Q

Dysphagia

A

Ddx:
Mechanical vs coordination

Intra-luminal, luminal, extra
motility vs neuro

Intra - Foreign body, oesophageal web, plummer vinson

Luminal - Cancer, oesophagi’s, barrett’s, benign stricture, chemical stricture

Extra - Retrosternal goitre, lung cancer, pharyngeal pouch, head and neck cancer

motility - spasm, achalasia
neuro - MG, bulbar palsy, cerebrovascular accident - 9, 10, 12 or coordination difficulty

Hx:
Liquids, solids, both - which started first
Sudden vs gradual, how long
Does it get stuck, does it feel like difficult to swallow - where is the difficulty
Regurgitate?
Full meal?
Where does it feel like food gets stuck
Any pain or painless (if pain cancer vs infection/ulcer)
GORD/reflux
Weight loss or chest infection?
Thyroid disease symptoms or previously
Any auto-immune / allergy related conditions
Any radiation / surgery / endoscopy / smoking
FmHx

Investigations:
FBC - eosinophils, WCC
EUC - baseline b4 PPI, sometimes electrolyte abnormalities
TFT if suspicion thyroid
Iron studies - if anaemic / plummer vinson
CRP - If infection
CMP - Para-neoplastic - also b4 PPI
Barium swallow, FNE, Endoscopy
CT oral contrast depending on presentation

More
H pylori infection

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10
Q

Haematemesis

A

Ddx
PUD
Variceal bleeding
- Other bleeding from rectum, ascites, jaundice, etc.
Tumour
- Constitutional symptoms
Mallory weiss - N+V excessive
Systemic cause of bleeding

Ensure not haemoptysis!!!

Prior to vomiting blood were they vomiting at all / nauseous
Do they normally have dyspepsia / chest pain before or after eating
Any malaena or change in bowel habit
Any recurrent use of NSAIDS or aspirin
Any diagnosed liver disease, have they ever noticed they were yellow
Any haemorrhoids, distended abdomen, easy bruising
Immunisations / needle use / alcohol intake / smoking
Any fevers/rigors/sweats/weight loss
Previous medical history, anaesthetic risk, allergies
Social and family history

If they are confused more likely hepatic encephalopathy as ammonia from urea not being metabolised adequately

Terlipressin for splanchnic vasoconstriction reduce flow through portosystemic shunt

Code blue and call on call endoscopist
ABCDE - need to intubate urgently to protect airway
Oxygen +++
Massive haemorrhage protocol, 2 wide bore IV, terlipressin, try and avoid over filling –> raises portal pressure and promotes further bleeding (better to give blood itself and aim for CVP 6-10, Pulse <100, Systolic >100 / MAP 65
May need to consider lactulose etc. if encephalopathic - keep monitoring
IDC for fluid status monitoring, ensure doesn’t become coagulapathic from massive haemrrhage
Must commence IvAbx as this prevents late septic complications
Sepsis may even sometimes (from SBP) lead to increased portal venous flow and lead to the variceal bleeding

When stable - focussed assessment including chart review, history, examination and then formulate plan

IR can consider TIPPS / embolisation if EBL not helpful

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11
Q

Hoarseness of voice

A

Consider - Oesophageal mass, Lung mass, otherwise could be primary throat/RLN issue from neck mass or thyroid mass

Could also be haematological or iatrogenic

Ddx
Infectious - Laryngitis, Croup, Laryngeal TB, Candida
Structural - Vocal cord nodule, HPV, Trauma, Paralysis of cord
Neurological - RLN palsy, Vagus nerve lesion (stroke, tumour), Parkinson’s disease, MG, ALS
Malignant - Cancer of larynx, thyroid, lung and oesopaghus
GI - Reflux, functional dysphonia
Endocrine - Hypothyroidism

Hx:
SOCRATES
Acute vs chronic
Intermittent or persistent
Dysphagia, dysphonia, SOB, Cough
Coughing up blood, progressive worsening
Lump
Fevers/rigors/sweats/unintentional loss of weight
Alcohol, smoking
Vaccinations, recent infection, TB previously
Reflux
Trauma
Weaknes/changee in sensation - FmHx neurological disease or cancer of larynx, thyroid or parathyroid, head and neck, oesophagus, blood
Heat/cold sensitivity, fatigue, weight gain, loss of hair, dry skin, palpitations or tremor
Easy bruising, lots of infections, anaemia
Immunosuppressed

EXAMINE

Ix:
FBC, UEC/CMP, TFT, CRP
USS if lump +/- FNA etc.
Could do CXR
Endoscopy/Laryngoscopy
CT for staging

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12
Q

Varicose veins + venous ulcer

A

Hx:
Previous DVT
Recurrent varicose veins / previous treatment
Stroke with weakness, neuromuscular disease
MSK injury of the area
Any abdominal pain, PR bleeding, PV bleeding
Any abdominal congestion, fevers/rigors/sweats

KTW syndrome PW syndrome

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13
Q

Raynauds

A

Ddx BADCAT

Blood disorders (polycythaemia), arterial drugs (BB, OCP), connective tissue disorders (RA, SLE, Scleroderma), Trauma

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14
Q

Thyroid history

A

Hyper
Increased appetite with loss of weight
Preference for cold
Increased sweating
Proximal myopathy with wasting and weakness
Diarrhoea + Frequency
Thacycardia + AF
Ameno/oligomenorrhea
Nervousness/irritability
Fine tremor

Hypo:
Weight gain and decreased appetite
Preference for hot weather
Dry skin, loss of hair
Muscle fatigue
Constipation
Bradycardia
Menorrhagia
Slow thought, depression, dementia
Symptoms of carpal tunnel syndrome

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15
Q

Causes of ptosis

A

Unilateral -
3rd nerve palsy
Horner’s - partial
Syphilis

Bilateral
Congenital ptosis
Myopathies - MG, dystrophia myotonica
Syphilis

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16
Q

Salivary gland tumour

A

Ddx
Benign - pleomorphic adenoma, warthog’s tumour, basal cell adenoma,
Malignant - Mucoepidermoid, adenoids cystic, acidic cell, carcinoma ex pleomorphic adenoma, SCC, lymphoma, metastatic
Mimicers - Sialadenitis, sialolithiasis, sjogren’s, IGG4 related disease, Sarcoidosis

Hx:
How quickly growth and pain
Any pain with eating
Any warmth or hot skin
Hard consistency vs soft
Fixed to skin
Weakness in muscles of face
Sensation near ear (greater auricular nerve) or face
Pus?
Dry mouth, dry eyes
Autoimmune diseases or connective tissue disease (RA, SLE)
Fevers/rigors/sweats/unintentional weight loss
Smoking history
Radiation
Other past medical history
Immunisations
Bruising/infections/known other cancer
Skin cancers - history of being in the sun a lot

What is Sjogren’s syndrome?
* Autoimmune condition - 90% occur in women at an average age of 50 years
* Intermittent or constant swelling of one or all of the salivary glands
* Clinical diagnosis if at least two of the following triad is present:
Keratoconjuctivitis sicca (dry eyes)
* Xerostomia (dry mouth)
* Associated connective tissue disorders
such as rheumatoid arthritis (50% of cases), scleroderma, systemic lupus erythematosus, polymyositis or polyarteritis nodosa
* If no associated connective tissue disorders are present, this is known as primary Sjbgren’s disease (note that Mikulicz syndrome is enlargement of the salivary and lacrimal glands secondary to sarcoidosis, lymphoma or tuberculosis, associated with dry mouth and dry eyes, but no arthritis)
* Pathology is lymphocyte-mediated destruction of the exocrine glands secondary to 8-cell hyper-reactivity and associated loss of suppressor T-cell activity
* Patients are at 40x increased risk of developing lymphoma, usually 8-cell non-Hodgkin’s type
* Several antibodies present, e.g. anti-salivary antibodies, rheumatoid factor, but two specific antibodies present - anti-SSA-Ro and anti-SSS-La

EXAMINE

Ix:
USS +/- FNA
CT/MRI for staging or to check facial nerve involvement
Autoimmune panel if Sjogren’s (ANA, Anti-RO/LA) + IGG4
Swab culture
FBC, CRP

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17
Q

Digital clubbing

A

Ddx

Gastro - cirrhosis, IBD, Malabsorption, lymphoma
Resp - Bronchial SCC, Lung disease (CF), Fibrosing alveoli’s, Mesothelioma
Cardiac - Cyanotic congenital heart disease, IE, Atrial myxoma
Rare - Familial

Cause - Multifactorial - TNF, Vagus affected, increased growth hormone, vasodilatation of nail-bed vessels secondary to unidentified factor which normally inactivated in lung, platelet precursors fragmented within pulmonary circulation - trapped in peripheral vasculature

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18
Q

Surgical jaundice

A

Pre, hepatic, post

Ddx; post op
Haemolysis from transfusion
Hepatic- anaesthetics, sepsis, intra/post operative hypotension
Post - bile duct injury

How long have you been yellow for
Any weight loss/appeitite/back pain
Fevers/rigors/sweats
Immunisations
Stool/urine
Pruritus
Foreign travel, recent blood transfusion
Alcohol
OCP/Phenothiazines
Drug use
Previous surgery - gallstones

Acuity of symptoms onset and then
Start with - any pain at all or any pain around meal-times
Any fevers/rigors/sweats
Previous gall bladder surgery or gall stones
Any change in bowel habit, PR bleeding
Any dark urine at all
Any itching
Any fatigue and unexplained loss of weight
Have you got any known liver disease or disease of the blood
Any recent blood loss or blood transfusion
Then ask about travel, IVDU, alcohol, sick contacts, unsafe sexual practices, tattooing or body piercing, recent illness, recent new medications
Any autoimmune diseases
Smoking, Pmhx, allergies, social history and family history

Ix:
At a minimum
Urine if dark urine make sure not haematuria
FBC - platelets, wbc
UEC - hepatorenal, urea, baseline
LFT - differentiate between cause
CRP - inflamattory/infective
Liver USS
Can do serology, AFP, other tumour markers, liver screen etc. depending on Hx
CT also depending on Hx including quad phase

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19
Q

Duputreyns

A

(a) What i s your differential diagnosis?
The differential diagnosis includes:
* Skin contracture - look for scar from previous wound
* Tendon contracture - thickened area, which moves on passive flexion of involved finger
* Congenital contracture of the little finger - affects PIPJ
* Ulnar nerve palsy - ring and little fingers are hyperextended at MCPJ and flexed at PIPJ.

Describe any tethering or pitting of the skin on the palmar aspect of the hand, and also note the appearance of any visible cords Look for scars from previous surgery
*
* Describe any flexion deformities at the metacarpophalangeal and proximal interphalangeal joints (MCPJ and PIPJ) of the involved fingers

  • Look for involvement of the thumb and the first web space (a sign of more aggressive disease)
  • Ask the patient to turn his hands over to look for Garrod’s pads (thickening of the subcutaneous tissues) over the PIPJ.
    Feel
  • Palpate the swelling, particularly noting its fixation to skin
  • Does the other palm have similar thickening? Move
  • Assess the range of motion in the involved fingers
  • Note the presence of fixed deformities by passively moving the involved joints.

(b) What conditions are associated with
Oupuytren’s contracture?
We have found the following mnemonic helpful to remember the associations - DEAFEST PAIL:
Diabetes mellitus Epilepsy
Age (positive correlation) Family history (autosomal
dominant)/Fibromatoses*
Epileptic medication (e.g. phenobarbitone) Smoking
Trauma and heavy manual labour Peyronie’s disease (fibrosis of the corpus
cavernosum - seen in 3% of patients with
Dupuytren’s)
AIDS
Idiopathic (most common)
Liver disease (secondary to alcohol).

(a) What i s the underlying pathophysiology of the condition?
Local microvessel ischaemia is thought to result in increased activity of xanthine oxidase, resulting in superoxide free radical production that in turn stimulates myofibroblast proliferation and type Ill collagen formation. Specific platelet-derived and fibroblast growth factors also play a role in the aetiology. Allopurinol, which inhibits xanthine oxidase, may help to reduce symptoms.
The process of chronic inflammation is thought to be essential to the subsequent fibrosis (see Further reading).

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20
Q

Carpal tunnel

A

DDx
* Anatomical abnormalities:
* Bone - previous wrist fractures, e.g.
Calles fracture, acromegaly
* Soft tissues - lipomas, ganglia
* Physiological abnormalities:
* Inflammatory conditions - rheumatoid arthritis, gout
* Alterations of fluid balance - pregnancy, menopause, hypothyroidism, obesity, amyloidosis, renal failure
* Neuropathic conditions - diabetes mellitus, alcoholism.
*Overuse / idiopathic

(b) Name one investigation you might perform before offering this lady treatment?
Nerve conduction studies:
* Symptoms of carpal tunnel syndrome can be mimicked by higher (more proximal) lesions of the median nerve. These high lesions are characterized by loss of sensation over the thenar eminence due to involvement of
the palmar cutaneous branch, and loss of the relevant forearm flexors (especially flexor pollicis longus)
* Symptoms may also be due to cervical nerve root lesions (e.g. secondary to a cervical disc herniation) or thoracic outlet syndrome
* Nerve conduction studies also assist in determining the severity of the lesion.

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21
Q

Lumbar disc

A
  • Age
  • Occupation
  • Features of the pain, especially site,
    radiation, any history of injury, and relieving
    and exacerbating factors
  • Neurological symptoms (e.g. weakness, numbness and paraesthesia) and their distribution
  • Sphincter disturbance - bladder and bowel symptoms (unlikely in patients used for examination purposes)
  • Effect on patient’s lifestyle, e.g. work, sleep
  • Previous treatments, e.g. use of analgesia, physiotherapy, caudal epidurals, operative
    intervention
    Explore other causes of back pain, e.g. diseases of the pancreas, abdominal aortic aneurysm, loin pain from renal causes.
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22
Q

Breast Lump

A

DDx
Benign - Fibroadenoma, breast cyst, fibrocystic change, lactational adenoma, lipoma, phyllodes tumour, hamartoma
Malignant - Ductal carcinoma, lobular, inflammatory breast cancer, paget’s disease of the nipple, phyloddes
Inflammatory - Mastitis, abscess, necrosis, mondor’s disease, granulomatous mastitis

Hx
SOCRATES
Lump history, lymph node history
Nipple discharge
Skin changes to breast
Risk factors
Menstruation early, late menopause, late age of first pregnancy or no pregnancy
HRT
Family history - BRCA? other cancers?
Fevers rigors sweats
Weight loss, back pain, shortness of breath
Autoimmune/Inflammatory diseases
Trauma, irritation, cream, allergy of skin anywhere else
Other health issues, allergies
Previous surgeries, anaesthetic risk
Social history, profession, requirement for reconstruction

Triple - Exam, USS +/- FNA, Mammogram —> Core biopsy/excisional biopsy –> definitive treatment +/- hormonal treatment

Mammography concerning features =
Mass of increased density
Ill defined margins
Speculated stellate architecture
Miicrocalcifications
Distortion of breast anatomy

extensive DCIS component, multi-focal disease, patient preference reasons for not sparing breast procedure, previous collagen vascular disorders

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23
Q

Burn history

A

IMIST from ambulance
What burnt patient - fire, electricity, oil, gas
Duration of contact
Ignition of clothing?
Closed environment?
ALOC
VIolent movement / trauma associated when falling
What PPE worn

AMPLE

ABCDE - EMST

Want to do secondary survey + assess which burns are deep dermal or full thickness, or partial derma

Capillary vasodilatation and recruitment closed capillary loops –> major extravasation of plasma to all interstitial tissues –> persists in areas under burn –> shock

Deep tissue death + vascular thrombosis = worsens this

Compartment syndrome highly likely

Without skin = rapid cooling with exposure –> raise room temperature + glad wrap

Bicarbonate to alkalinise urine making pigments water soluble (haemochromogens)

4thj degree = deep to subcutaneous fat

Watch for ARF and sepsis

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24
Q

PR Bleeding

A

Ddx
Lower GI
- Haemorrhoids, fissure, diverticular, CRC, angiodysplasia, proctitis (radiation, IBD, infection), ischaemic colitis
Upper GI
- PUD, varices, fistula
Small bowel
- Crohn’s, Meckel’s, GIST/Carcinoid/Adenocarcinoma

Vascular
- Coagulopathy, thrombocytopenia, HHT

Hx:
SOCRATES
Where when how often blood
Painful/painless/colour
Chronicitity
Mucous/pus
Diarrhoea/frrequency
Constipation before episode
Symptoms better or worse after food
Fevers/rigors/sweats/suspicious food/unintentional weight loss
Recent travel
Fatigue/Dizziness on sitting or standing/Palpiations
FmHx auto-immune/IBD/Cancer
FOBT/Colonoscopy
Recent NSAID or anticoagulant use
Radiation/SMoking/Alcohol
Liver disease/yellow skin
H pylori/dyspepsia/
Easy bruising/bleeding elsewhere/petechiae
Skin lesions
Systems review

MUST EXAMINE INCLUDING DRE

Ix:
FBC, UEC - urea, iron studies, LFT, CRP
Colonoscopy
CT angiography
Capsule endoscopy

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25
Q

CLI DDx

A

Spinal canal disease
Sciatia
Peripheral neuropathy

Risk factors
Smoking diabetes, HTN, Genetic Dyslipidaemia

Aetiology
- Atheroscloeris, buergers, vasculitis, arterial trauma, adventitial disease,

26
Q

Breathlessness and weight loss

A

DDx
Respiratory - Lung cancer, tuberculosis, COPD, interstitial lung disease, pulmonary fibrosis, pulmonary embolism, metastatic cancer
Cardiovascular - Heart failure, pulmonary hypertension, endocarditis
Infectious - Tuberculosis, HIV/AIDS, chronic fungal infections
Haem - Lymphoma, anaemia, leukaemia
Metabolic/Endocrine - Hyperthyroidism, adrenal insufficiency, diabetes
Autoimmune - Sarcoidosis, rheumatoid lung disease, systemic lupus erythematosus (SLE)

Hx
Nature and severity of shortness of breath
After how much Exertion
How rapidly did this develop
Rest, during night, when lies flat (how many pillows, wake up sob)
Cough, productive, blood
Weight loss
Fevers/rigros/sweats
Smoking history
Asbestos
Family hsitory
Foreign travel
Family history other cancers
Previous blood clots or DVT
Hoarseness of voice
Difficulty swallowing

FBC, UEC, CMP, LFT
CXR
ABG
Sputum MCS, AFB, Cytology

27
Q

Hypertension

A

DDx:

Hx:
SOCRATES
Rule out hypertensive crisis - irritability, headache, visual disturbances, confusion, altered consciousness, seizures
Renal disease - polyuria, nocturne, dysuria, thirst, haematuria, colic, lethargy, general malaise
Phaeo- sweating, palpitations, anxiety, tremor - in paroxysms
Cushings - truncal weight gain, thinning of skin, easy bruising, proximal myopathy, striae, hirsutism
Heart failure symptoms
Back pain
Chest pain
NSAIDS, OCP, HTN drugs, Steroids, Antidepressants
Tobacco, alcohol, illicit drugs
Family history
Known renal disease, pre-eclampsia when pregnant, known arterial disease
Thyroid disease

28
Q

Collapsed young man

A

Ddx - head trauma, tumour, mets, stroke, CNS infection, metabolic disorder - hypoglycaemia, hyponatraemia, hyperclacaemia, medication, drug withdrawal

Risk factors - non-compliance, viral, abuse of alcohol, sleep deprivation

How did seizure start, any aura
Any focal or lateralising features at seizure onset
Seizure duration
Time taken to recover

What happened before, during and after

Any witnesses

FmHx, associated symptoms (fevers)

Past history head trauma, neurological illness, cardiovascular, cancer, drug and alcohol consumption

29
Q

Leg weakness / foot drop

A

FINISH THIS

Sudden onset or gradual
Any associated pain at all
Any preceding trauma, stretch, peripheral nerve injury
Any weakness in any other limb or region on the same side
Any back pain
Any symptoms on the other side as well
Any fevers/rigors/sweats
Any unexplained weight loss
Any headache, any nausea or vomiting - particularly in the morning or when’s training
Any seizures
Any visual symptoms, weakness, numbness anywhere else,
Bowel and bladder disturbance
Any autoimmune disease
Any immunosuppression or diabetes
Family history of anything to do with brain, norves, brainstemV

30
Q

Vertigo

A

Need to distinguish whether they are lightheadded for which Ddx
- Cardiac arryhtmia, postural hypotension, anaemia, hypoglycaemia, loss of consciousness (syncope or epilepsy)

Otherwise vertigo - world spinning around them
- spontaneous, recurrent, changes in posture

Need to clarify whether peripheral or central
- vertebrobasilar ischaemia, dyelinatioatn, cerebellar disease, migraine, vasculitis CNS, neuromyelitis optica
- temporal lobe epilepsy
- cerebelloponine angle tumour - deafness, ataxia, facial sensory loss

Peripheral
- BPPV, vestibular neuronitis, meniers disease, middle ear dieseae

Vestibular apparatus vs vestibular nuclei and connections

Hearing loss
Vision loss,
Tinnitus
New weakness / change in sensation / difficulty walking or balancing
What brings on symptoms
How long for
Fevres/rigors/sweats
Headache or any pain
N+Vomiting,
tongue biting or incontinence
Cardiac risk factors and diseases
Family history and personal history of any neurological diseases, migraines, tumours

FINISH THIS

31
Q

Back

A

DDx

Vascular
- Intermittent claudication
- Chronic venous insufficiency

MSK
- Joint disease
- Muscle/ligament injury
- Stress fracture

Neurogenic
- SCiatica
- Spinal canal stenosis
- Cauda equina syndrome

How long
Any associated pain
Is it shooting - how far down does it go (if not further than knee probs not sciatica)
Any associated weakness / change of sensation
Any bowel or bladder changes
Any fevers/rigors/sweats , recent infection
Any loss of weight, constitutional symptoms, neurological disease/tumoru FmHx
Any clots / vascular issues
Cardiac issues Hx

FINISH THIS

32
Q

Joint History approach

A

Site
Quality
Severity - effect on life
Time course ?insidious
Context - recent illness, STI, trauma, travel
Aggravating factors
Relieving factors
Fevers/rigors/sweats
Sensory/Weakness
Sore throat
Weight loss
Headache
Gait disturbance
Rashes ulcers
Genital discharge
Dysuria
Sicca symptoms
Raynauds
Diarrhoea

Autoimmune, IBD, OP, bleeding disorder
IVDU/smoking/eTOH

Occupation

33
Q

Constipation

A

Structural - associated pain, bulge, constitutional symptoms, onset, family history
- Hernia
- Cancer
- Appendicitis
- Intusseception
- IBD?
Dietary
- Alcohol
- Caffeine
- Dehydration
Medications
- Opioids
- Anti-histamines
- Laxative use
- Anti-diarrhoeals
Metabolic/Endocrine
- Hypercalcaemia
- Hyperparathyroidism
- Hypothyroidism
Neuromuscular
- Parkinson’s
- Cauda Equina
Congenital
- Hirschprung’s
- Cystic fibrosis

FINISH THIS

34
Q

How to differentiate between ulcers

A

DDx
Arterial
Neuropathic
Pressure
Venous

Other Ddx same as leg laceration

Hx:
SOCRATES
Location, pain
Leg swelling, aching, heaviness, itching
Varicose veins, DVT, obesity, prolonged standing, previous venous surgery
Severe pain worsening with elevation, claudication, rest pain, cold feet
Smoking, diabetes, hypertension, dyslipidaemia, PVD,
Painless, numbness, tingling, burning
Diabetes, alcoholism, spinal cord disease
Fevers/rigors/sweats
Immobility, malnutrition, sensory loss

Exam:
Location
Margins, exudate
Surrounding skin
Peripheral pulses
Capillary refill

Complete neurological exam - monofilament and vibration testing

Confirmatory tests
Doppler USS
ABI
CT angiography
HBA1c
May require imaging to rule out deep infection such as CT

35
Q

Leg laceration

A

Ddx:
Traumatic
Sharp force
Blunt force
Crush
Avulsion
Bite wounds

Non-traumatic
Infectious
- Nec fasc
- Cellulitis
- Mycobacterial or fungal infection
- Cutaneous anthrax
Ulcer
- Venous, arterial, neuropathic, pressure
AUtoimmune/Derm
- Pyoderma gangrenosum
- Epidermolysis bullosa
- Vasculitis
- Lichen sclerosis
SCC/BCC/Melanoma

History:
SOCRATES
Foreign material, what object, how, dirty, tetanus, occupation
Pain - out of proportion?
Wound progressionl
Walk / cold feet / neurological symptoms
Anywhere else
Fevers/rigors/sweats
Risk factors for causes - ulcers, skin condition, skin cancer, auto-immune, derm,
Unintentional loss of weibght / radiation
Auto-immune
Recent travel
Previous TB

MUST EXAMINE including neurological exam

Ix:
Wound swab!!, BSL at bedside!!
FBC - infection
UEC - Risk for PAD
CRP - Inflamamtory/INfection
Blood cultures - infection
HBA1c - diabetic
LFT - Albumin ?poor healing
Autoimmune panel
X-ray for gas
CT?
ABI/USS/
MRI for OM

Punch vs excision biopsy

36
Q

Loin Pain

A

DDx
Renal - stone, RCC, pyelo, abscess, infarction, trauma, obstructive uropathy
GI - Appendix, diverticulitis, IBD, Gall bladder, Pancreatitis
Vascular - AAA, Retroperitoneal haemorrhage
MSK - Muscle strain, vertebral pathology, herpes zoster
Reproductive - Torsion - ovary and testicular, endometriosis, PID
Neurological - Radiculopathy, spinal cord compression, diabetic

Hx:
SOCRATES
LUTS, haematuria, dysuria
Fevers/rigors/sweats/loss of weight
Bowel habit, Malaena, Jaundice, Pruritus
Previous surgeries of bowel, kidney, reproductive
Leg pain on walking, Previous easy bruising/bleeding, anticoagulation
Strain, previous issues with back, trauma, burning followed by pain and rash on one side of body
Periods / scrotal pain / discharge
Any trouble with sensation around anus, any weakness/change in sensation

I WOULD EXAMINE

Ix:
Urine dip + MCS, BSL/ECG if required but unlikely
FBC, UEC, CRP, LFT, Coag
CT depending otherwise USS repro

37
Q

Haematuria

A

Ddx:
Urological
TCC/Prostate cancer/RCC
UTI
Stones
BPH
Trauma
Radiation cystitis
Iatrogenic
Schistosomiasis

Non-urological
Systemic - Coagulopathy, vasculitis, sickle cell
Vascular - Renal artery dissection, malignant hypertension, aneurysm rupture
Renal - PCKD, Glomerulonephritis
Drug induced - abx, ibuprofen, cyclophosphamide
Pseudo - jaundice, rhabdo, porphyria, beeturia, drugs (rifampicin)

Hx:
SOCRATES
Painful vs painless
- Smoking, occupation, exposure to paints/dyes
Infective vs non-infective
Constitutional symptoms
LUTS
Previous urological and fmHx of urological/kidney/other cancer or no cancer
Pelvic radiation
stones / neck mass / constipation
Bleeding / bruising / epistaxis / bleeding anywhere else
Trauma
Travel overseas
Hypertension / headache/blurry vision
Medications
Cough/chest infection/swelling in legs
After finish Hx - do systems review –> Notice skin yellow, recent long run / long lie, eating beetroot, weakness/change in sensation

Examine patient

Ix:
Urine dip + MCS
Urine cytology x3
Urine red cell morphology
FBC, UEC, CRP, Coag, PSA, LFT if suspicion of pseudo/coagulopathy, autoimmune panel if worried about auto-immune, sickle cell screening
CT IVP/RTUS
Flexible cystoscopy

38
Q

Scrotal Swelling

A

Ddx
Urological
Torsion / torsion of appendage
Epididymo-orchitis
SCrotal trauma
Fournier’s
Iatrogenic
Tumour
Kidney stone
Varicocele/Spermatocele/Hydrocele
Idiopathic

Non-urological
Hernia
Parasitic infection
Lymphadenopathy
Oedema

Hx:
SOCRATES
Sudden onset and when
Pain and if so - Constant / coming and going
Able to get over or not
Testes in origin or scrotum
LUTS? Haematuria? Dysuria?
Fevers/rigors/sweats/unintentional weight loss
FmHx cancer
Trauma
Flank pain / previous kidney stones
Heavy lifting / previous hernia
Recent overseas travel / any travel
Swelling anywhere else in body
Lumps or bumps anywhere else

Examine!!
- Able to get over / under, transilluminate, prehn, cremasteric,

Ix:
Urine dip + MCS
Urine STI screen
USS
FBC - anaemia/wcc, CRP - inflammatory/infection, UEC - stone
AFP, LDH, Beta HCG
CT CAP if feels obvious tumour or CT AP if large hernia

39
Q

Post op chest pain

A

Ddx
Cardiac - MI, Pericarditis, Tamponade
Pulmonary - PE, PTX, Pneumonia
GI - Oesophageal rupture, GORD, PUD
MSK - pre-existing
Surgical - related to laparoscopy or thoracotomy etc.
Anxiety
LUQ Abdominal pain
- Pancreatitis, Haemorrhage, Mesenteric ischaemia, splenic infarct or pain, aortic dissection, kidney stone, herpes zoster:

Hx:
SOCRATES
Acute vs chronic
Pre-op or only post op
Insidious
Related to breathing?
Exertional?
Sitting up or lying down?
After or before food?
SOB / cough / coughing up blood
Fevers/rigors/sweats
Cardiac risk factors - Previous MI, FmHx, Diabetes, Dyslipidaemia, HTN
Leg swelling or pain
Palpitations or dizziness especially on sitting or standing
Previous blood thinners / previous DVT

Ix:
ECG
Trop, ABG (alkalosis), FBC, CRP, Coag
CXR - PTx, Pneumonia, Widened mediastinum or mediastinal air
CTPA/Gastrograffin swallow
Echocardiogram

40
Q

Diarrhoea

A

DdX:
Viral/bacterial/antibiotic/parasitic - gastroenteritis
IBD
IBS
Cancer
Bile acid diarrhoea / CLD
Coeliac/Lactose/Pancreatitis related/SIBO
Endocrine / Metabolic - Hyperthyroidism, Carcinoid, VIPoma, Addison’s
Medication induced
Post surgical - short bowel/fistula/dumping syndrome

Hx:
SOCRATES
How many stools
Acute / chronic
Watery/Bloody
Tenesmus, fevers/rigors/sweats/unintentional weight loss
Abdominal pain ?relieved by diarrhoea
Recent travel
FmHx CRC/IBD/Autoimmune
Iron deficiency / steatorrhea, after dairy ingestion/gluten
Yellow skin, pruritus, Liver disease, biliary surgery, gall bladder
Tremors/AF/Loss of hair/Heat insensitivity/
Hyperpigmentation of skin and low blood pressure (dizziness on sitting and standing)
Flushing/dehyrdration
Antibiotics/Laxatives/PPI/Metformin
Recent surgery

Stool culture + MCS, calprotectin
FBC, CRP, TTG IGA, LFT, UEC for dehydration, consider lipase,
May require colonoscopy especially if overdue
ACTH and cortisol if Addisons’

41
Q

Abdominal pain

A

Ddx:
RUQ - Cholecystitis, Cholangitis, hepatitis, Liver abscess, Pyelo, Kidney stone
LUQ - Gastritis, PUD, Pancreatitis, Splenic infarction or rupture, Pyelo, Kidney stone
Epigastric - GORD, MI, Aortic dissection
RLQ - Appendicitis, Crohn’s, Torsion/cyst rupture, ectopic
LLQ - UC, Ovarian, Diverticulitis
Generalised or vascular - Mesenteric ischaemia, AAA, Peritonitis, Cystitis,
Any malignancy - Kidney, Bowel, Liver, Other

Hx:
SOCRAATES
When start
Radiate
Fever/vomiting/diarrhoea/weight loss/blood in stool/change in bowel habit
Previous surgeries, CVD, Smoking, NSAIDS
Urinary symptoms, dysuria
Medications - NSAID, Opoid
Stones
Gynaecological hx, urological hx
Autoimmune/IBD
FmHx any of above including any cancers
Previous gallstones/pancreatitis
Jaundice, pruritus, liver disease things
Sexual hx, discharge
Muscular strain

Must examine!!! Including DRE

Ix:
FBC, UEC, CRP, LFT, Lipase
CT AP

42
Q

Haemoptysis

A

Ddx
Respiratory
PE
Bronchial artery rupture
Lung cancer
TB
Pneumonia
Abscess
Aspergillosis
COVID, Influenza, viral pneumonia
COPD
SLE/Vasculitis
Bronchiectasis

Non-respiratory
Coagulopathy. TTP
AAA
Mitral stenosis
Heart failure
Ensure not haematemesis
Iatrogenic

Hx:
SOCRATES
How much and since when
Fresh or dark red
Blood streaked sputum?
Fevers/night sweats/weight loss
Smoking, TB, Travel
Surgery OCP
Pleuritic chest pain, shortness of breath, leg swelling
Orthopnoea, PND
Nosebleeds brusing, bleeding gums, epistaxis
Haematuria, joint pain, rash
Autoimmune
Anticoagulant

EXAMINE

Ix:
Sputum MCS, ECG
FBC, Coag, UEC (urea), CRP
Depending on Hx could do D-dimer/ANCA/Anti-GBM and LFT
CXR at a minimum
Otherwise CT Chest/CTPA
Bronchoscopy?
Endoscopy?

43
Q

Melanoma

A

Ddx:
Skin cancers - BCC, SCC, kaposi
Benign skin lesion - seborrheic keratosis, blue/spitz nevus, solar lentigo, pigmented dermatofibroma
Pre-malignant - atypical naves, lentigo maligns, actinic keratosis
Addison’s disease, PIH, Drug eruption, tattoo

Hx:
SOCRATES
- Raised, flat, vascular, changing with time, itchy, bleeding, crusting
Trauma or irritation
Sun exposure, occupation, whether wear sunscreen or not (and where), tanning bed, moles
Often get sunburnt, fair skin, red/blond hair
FmHx
Other skin lesions
Previous skin cancers
Fevers/rigors/sweats/unexplained weight loss
Bony pain, persistent headache, vision changes
Autoimmune diseases or immunosuppression
Do you feel weak, tired, episodes of fainting or light headedness on standing, hyperpigmentation, N+V or diarrhoea
Systems review

Ix:
EXAMINE
Dermascopy
Excisional biopsy
Could do FBC, CRP ensure not infected lesion, Coags if indicated

44
Q

Post-operative pain (abdominal)

A

DDx
Expected post-operative
Wound and soft tissue complication - infection/haematoma/seroma/dehiscence
Abscess/peritonitis/NF
Post-operative haemorrhage, compartment syndrome, ischaemia
nerve injury, neuropathic pain
Pneumothoraxi, Bowel obstruction, urinary retention
MI / PE / DVT
Pneumonia
Ileus

Hx:
SOCRATES
Fever, erythema, wound discharge
Dizziness sitting and standing, cool peripheries
Abdominal distention N+V
SOB/chest pain
hypoxia
Leg swelling, redness, diaphoresis
Previous cardiac history if chest pain
Diabetes obesity smoking immunosuppression

EXAMINE - bladder scan, DRE - pelvic abscess, DVT

Ix:
Urine dipstick + MCS, ECG,
FBC, CRP - inflammation infection
UEC - post op ileus electrolyte
Trops
LFT - bile leak liver dysfuction
Coag - DIC
ABG - acidosis - ischemia, sepsis
CTPA/Doppler USS
Wound MCS
CXR for pneumonia
CT for anastomotic leak

45
Q

DVT risk pre-op

A

DDx/Risk
Immobilisation
Malignancy
Pregnancy
Thrombophilia/Antiphospholipid syndrome
Recent surgery
Previous DVT
Nephrotic syndrome
Ortho/Abdominal/pelvic surgery/neurosurgery/>3 hour surgery
OCP

Wells -
Active cancer (treatment ongoing or within 6 months) +1
Paralysis, paresis, or recent immobilization of a limb +1
Bedridden for ≥3 days or major surgery in past 4 weeks +1
Localized tenderness along deep venous system +1
Swelling of entire leg +1
Calf swelling >3 cm compared to other leg +1
Pitting edema +1
Collateral superficial veins (non-varicose) +1
Alternative diagnosis more likely -2

Virchow - stasis, hypercoagubility, Endothelial

Hx:
SOCRATES
Leg pain, swelling, redness
Immobilisation
Chest pain, SOB, Haemoptysis
Neurological deficits (PFO), stroke like
Weight loss, night sweats, unexplained fatigue,
Previous DVT PE
History of clots - factor 5 protein C/S, APLS
Smoking OCP, HRT
Recent surgery

EXAMINE

Ix:
D Dimer
Coags
Thrombophilia
Venous doppler USS
CTPA
Echo

46
Q

Post-operative delirium

A

Ddx:
Infective - Pneumonia, UTI, wound, Sepsis of other cause, post-operative
Metabolic - hypoxia, hypoglycaemia, electrolyte, uraemia
Neurological - stroke, seizure, haematoma, pre-existing dementia
Medications - opioids, benzodiazepines, anti-cholintergics, polypharmacy, alcohol withdrawal, anaesthetic related
Cardiovascular - hypotension, hypertensive crisis, MI
Uncontrolled pain, psychosis, surgical stress response

Ensure not psychiatric, dementia, POCD

Hx:
SOCRATES
Fluctuating or persisitent
Lucid?
Fever/rigors/sweats
Tachycardia/cough/dyspnoea/chest pain/weakness/change in sensation/agitation/rtremors/dehydration/pain
Urinary symptoms
Wound
Post-operative course
DVT/PE
Drugs given
New medications
previous Delirium
Pre-existing cognitive impairment
Bowels
Systems review

EXAMINE - bladder scan, DRE

Ix:
ECG, BSL
FBC, CRP, UEC, LFT (hepatic encephalopathy)
Blood cultures, CXR, Urine MCS
ABG
Tox screen

CT Brain
RTUS
USS doppler

47
Q

Pre-op bruising

A

Ddx:
Medications - anticoagulant, anti-platelet, NSAID, SSRI, Corticosteroid
Platelet disorders - thrombocytopenia, platelet dysfunction, congenital platelet disorder
Coagulation factor deficiency - Hemophilia A/B, Liver disease, Vitamin K deficiency (warfarin, prolonged antibiotics, malabsorption)
Vascular fragility - Euler’s Danos, Marfan
Systemic - CKD, Liver disease, MM
Nutritional - Vitamin C and K
Cushings/Diabetes/CKD/Age/Hematologic
Amyloidosis/DIC sepsis related

Hx:
SOCRATES
Spontaneous, trauma, mucosal bleeding, petechiae, haemarthrosis, haematoma
Location, Epistaxis, GI bleeding, haematuria
Liver disease, anticoagulants
Medications
CKD/Cushing’s
Fatigue, weight loss, fevers, rigors, sweats
Weight gain, moon face, buffalo hump
Skin changes
Autoimmune disorder
Infective signs - Chest, urine, skin - chronic infections
Neurological signs?
Food alcohol intake
Smoking

EXAMINE

Ix:
FBC, Blood film, Clotting, LFT, UEC - CKD, D-dimer, Von willebrand, Factor 8 and 9, Vitamin C and K
Cortisol

CT/Brain MRI?
Abdominal USS - Hepatosplenomegaly
Bone marrow biopsy

48
Q

Projectile vomiting in child

A

Ddx
Hypertrophic pyloric stenosis (early)
Intestinal atresa
Malrotation with midgut volvulus
Metabolic disorder -

GORD
Food intolerance
Infections
Intra-cranial pressure

Gastroenteritis
Increased intracranial pressure
Appendicitis
Toxin ingestion
Liver disesase
Metabolic disorder (urea cycle defect), organic academia

Hx:
SOCRATES
Projectile or not
Bilious or not
Bloody or coffee ground
Feeds
Morning
Abdominal distension or pain/constipation
Weight loss, dehydration, ltheragy
Drawing up of legs
Bulbing fontanelle, seizures
Fever, poor feeding, irritability, neck stiffness
Unintentional loss of weight
FmHx cancer
N+V
Smelly urine, Diarrhoea,
Premature, issues with pregnancy
Pre-eclampsia
FmHx GI issues
Yello0w, scratching,

EXAMINE - pyloric mass, ICP, bulging fontanelle, fluid status

Ix:
Glucose, urinalysis
FBC, CRP
UEC - electrolyte
LFT, Ammonai,
Gas - alkalosis = stenosis, acidosis sepsis/shock/inborn errors
Bilirubin/LOFT - neonatal liver disease

49
Q

Incontinence

A

DDx
Stress - weak pelvic floor (previous complicated birth), cachexia, previous prostatic surgery, pelvic organ prolapse, rectal prolapse
Urge - infection, detrusor overactivity, TCC at trigone
Overflow incontinence - HPCUR, BOO (cancer or non-cancer)
Functional incontinence - Dementia, stroke
Neurological - MS, Parkinson’s stroke, spinal cord injury
Metabolic - DM, Hypercalcaemia with nephrogenic DI
medications - diuretics, anticholinergics, opioids
Mixed

Hx:
SOCRATES
SUI/UUI
LUTS - haematuria
Rule out infection, fevers/rigors/sweats/flank pain/rUTI’s
FmHx prostate cancer / PSA
Unintentional loss of weight
Smoking, occupational exposures, blood thinners, pelvic radiation
Prolapse of organs
Pregnancy history
Surgical history
Weakness/change in sensation anywhere
Obesity
Mediations
COPD/Cough
Situational
Stones / constipation / abdominal pain

EXAMINE INCLUDING DRE and PV exam

UROFLOW

Ix:
FBC, CRP, UEC (HPCUR), HBA1c, Calcium (hypercalcium), PSA blood test
Urine dipstick + MCS

RTUS + Cystoscopy

MRI spine if neurological cause

Further down the track urodynamics to diagnose detrusor overactivity

Rule out reversible causes
Pelvic floor physio
Bladder training
Medication - Anti-cholinergics, oestrogen, ISC

Sling/botox/sacral nerve stimulation/TURP

50
Q

Iron deficiency anaemia

A

DDx
Blood loss
- GI bleeding, menorrhagia, post surgical, haematuria, blood donation
Malabsorption
- Coeliac, H pylori, gastrectomy, IBD, bariatric
Dietary deficiency
- Vegetarian, vegan, pregnancy
Increased demand
- Children/Pregnancy
Chronic liver disease/Crhonic kidney disease

IDA Mimics - Chronic disease, thalasaemia, lead poisoning, sideroblastic

Hx:
SOCRATES
Fatigue, weakness, exercise tolerance
Dizziness on sitting/standing
Pallor
Pain any where? Radiating to back
Bowel symptoms
Bladder symtptoms
Swelling anywhere
Recent surgery
Craving for ice/dirt/starch
NSAIDS/Epigastric pain/reflux
Periods!
Chronic diarrhoea, GI surgery
H pylori
What diet
RA/CKD/Chronic
Autoimmune
Loss of weight / fevers/rigors/sweats
Recent infection
Yellow/liver/kidney/

EXAMINE

Ix:
FBC, Iron sudies
Coeliac, breath test, LFT if chronic liver disease
Stool cal pro / colonoscopy/endoscopy
CT AP
CXR

50
Q

Dislocated shoulder

A

Ddx:
Anterior EXT ABD - FOOSH
Posterior INT ADD - Seizure, electrocution, FOOSH
Inferior ARM above - high energy trauma, hyperabduction

Other causes
Fractures
Rotator cuff injury
Labral tear
AC joint
Brachial plexus
Septic arthritis
Shoulder impingement

See shoulder pain for Hx IX

Important for axillary nerve and radial pulse

3 view x-ray

Humeral head where is it

Hill sachs - cortical defect for choronic

Glenoid rim fracture - Recurrent instability

CT/MRI

51
Q

Anorexia/weight loss

A

Ddx
Systemic/Malignancy - GI, Lung, Haematological, RA/SLE, Chronic infection (TB, HIV, Endocarditis)
GI - Coeliac, IBD, Pancreatitis, PUD, gastropareasis, stricture/cancer of oesophagus
Endocrine - Hyperthyroidism, Adrenal, DM, CKD
Psychiatric - Eating disorder, depression/anxiety, dementia/ALS, Substance use
TB/HIV/Parasite
Medication - Stimulants, Chemotherapy, metformin, SSRI’s
Post GI surgery, Radiation
heart failure
COPD

Hx:
SOCRATES
Amount
Intentional vs not intentional
Normal appetite but weight loss, loss of appetitie, early satiety, difficulty swallowing, painful swallowing
Diarrhoea, steatorhea
Fevers/night sweats/rigors
Abdominal pain, rectal bleeding
Tremor, heat intolerance, palpitations, skin changes including hyperpigmentation, salt craving, dementia, memory loss, weakness/change in sensation
Family history cancers - lung, liver, bowel, prostate, breast, blood
Alcohol, drugs, smoking
Recent travel
Medication - suppressant, chemo, SSRI
Heart failure
COPD
Systems review

EXAMINE including BMI

Ix:
FBC - anaemia, WCC infection
CRP - infection, malignancy
LFT - malignancy, albumin
UEC - Electrolyte imbalance from metabolic, CKD
CMP - malnutrition paraneoplastic
TFT , ACTH, Serology (coeliac, HIV)
Stool examination, culture, calprotectin

CXR/Abdominal USS/CT AP
Endoscopy/Colonoscopy

52
Q

Post operative fever

A

Ddx
Atelectasis, Aspiration, Pneumonia, SIRS, UTI, Central line, drug fever, wound, DVT/PE, C difficile, Deep surgical infection, Endocarditis, HITS
Normal inflammatory response
Undiagnosed malignancy/lymphoma

Hx:
Onset, recurrent, level
Sustained, spiking
Feeling of hot
Rigors/sweats
Cough/runny nose/sob
Deep breathing post-op, sitting out of bed
Dysuria/frequency/flank pain
Redness, pain, discharge at wound site
Diarrhoea, nausea+vomiting
Leg swelling, redness of leg, calf pain, previous clot in leg
Abdominal pain
Mobilising
Eating
Rash anywhere on body
Systems review
Confusion?

EXAMINE

Ix:
Urine dipstick, ECG (right heart strain)
FBC, CRP - infection
UEC - dehydration/kidney function in setting sepsis
LFT - drug reaction

Blood cultures/urine cultures/sputum culture/wound swab/Faecaes PCR
CXR
Doppler USS vs CTPA

53
Q

Paediatric neck mass

A

Ddx
Congenital - branchial cleft, thyroglossal, dermoid, cystic hygroma, teratoma
Infectious (MOST COMMON) - Reactive, bacterial, tuberculous, mycobacterial, cat stretch, viral, fungal, septic thrombophlebitis, abscess
Inflammatory - Kawasaki, JIA, Sarcoidosis
Neoplastic - Lymphoma, leukaemia, neuroblastoma, thyroid, salivary gland tumour
Vascular - AVM, Haemangioma
Neuroblastoma

Hx:
SOCRATES
Pain, onset, stable, soft/fim, mobile/fixed
Fever/sore throat/weight loss/night sweats
Dysphagia, hoarseness, cough, skin changes, SOB
Skin changes
Recent infections, travel
Cat scratch/animal exposure
Immunosuppresion
Family history of cancer/autoimmune disease
Conjunctivitis/rash
Thyroid symptoms
Exposure to smoking
Weakness/chagne in sensation/Dizziness
Bleeding bruising

Ix:
EXAMINE

FBC, CRP - infection
Viral panel / serology
Throat swab / blood culture
LDH /
USS +/- FNA
CXR

54
Q

Supraclavicular Mass

A

DDx
Lymphadenopathy - Reactive, granulomatous disease, lymphoma, metastatic (stomach, pancreas, colon breast on left, thoracic lung and oesophagus breast on right), leukaemia
Infectious - TB, Lymphadenitis (Staph/Strep), Cat scratch, fungal, vira
Congenital - Cyst - branchial or thyroglossal
Vascular - Carotid body tumour, subclavian artery aneurysm, jugular vein DVT
Cancer - Thyroid cancer, Salivary gland, sarcoma
Goitre/Sarcodiosis

Hx:
SOCRATES
Fixed, hard vs mobile
Painful
Warm/red
Growing
Night sweats/fevers/unintineional loss of weight/rigors
Which side
Sore throat, recent travel, TB, skin infections, dental infections
Cough, blood, sob
Difficulty breathing, N+V, early steatite, vomiting blood, maelaena
Easy bruising/infections
Breast lump - pain, discharge
Thyroid symptoms
Radiation
Other malignancies
Immunosuppressed
Smoking/alcohol/HPylori/Reflux
Weakness/ change in sensation/numbness down either arm or anywhere
Cool peripheries
Ulcers/skin changes

Ix:
EXAMINE

Lymph node, thyroid, neck, abdominal, respiratory, breast

FBC, CRP infection, malignancy, LFT in case GI origin, UEC - urea bleeding, baseline uec

Optional
TB/HIV/EBV/CMV
CEA/Ca19.9, AFP, PSA, TFT

USS +/- FNA
X-ray if resp
CT staging

55
Q

Tongue ulcer

A

DDx
Viral - HSV, VZV, HPV, HIV
Bacterial - Syphilis, TB
Fungal - Candidaisis, immunocompromised
Inflammatory - Aphthous, behcet’s disease, IBD, Reiter’s (reactive arthritis)
Benign - Papilloma/fibroma/haemangioma
Premalignant - leukoplakia/erythroplakia
Malignant - SCC, lymphoma, kaposi
Metabolic - CKD Stomatitis, IDA/B12
Drug - Chemo/Bisphosnophate/NSAID

Hx:
SOCRATES
How long for
Healing or not
Painful or painless
Lymphadenopathy
Fevers/rigors/sweats/loss of weight
Smoking / Alcohol / FmHx cancer / Tongue
Any other lumps anywhere else
Immunosuppression / DM / IBD / Autoimmune disease
Joint pain / issues with urinating (pain) / red eyes infected
Skin lesions in genital area
Final infection / viral infection
Vaccinations
Previous Herpes / potential new risk (new sexual contact)
Previous TB / cough / sob
Recent travel
What medications
Any cancer
Dizziness sitting standing

EXAMINE - Neck + ENT

Ix:
FBC, CRP - infection
UYEC - Uraemiec stomatitis
IDA/VItamin B12/Folate
HBA1c
Autoimmune panel potentially
PCR swab / MCS / Syphilis / fungal culture
Quantiferon test

USS +/- Xray if dental involvement or CXR if chest
CT vs MRI depending on that

FNAC vs biopsy

56
Q

Hip Pain

A

Ddx
MSK - OA, FAI, Labral tear, Greater trochanter, AVN, Hip/Stress fracture, Muscle strain, Snapping hip, Legg-Calve Perthes, SCFE
Neurological - SCiatica, Piriformis, Lumbar spinal stenosis, femoral neuropathy, meralgia paresthetica
Inflammatory - IBD, RA, Gout/Pseudogout
Infective - Septic, OA, Tuberculosis, Lyme
Referred- Lumbar, inguinal hernia, SI joint, Pelvic (prostate appendix ovary)
Vascular - Claudication, DVT
Trauma
Neoplastic - Primary, mets, lymphoma

Hx:
SOCRATES
Onset
Worsened by activity or better with it
Clicking / locing
Corticosteroid use/alcohol.trauma/deep persistent pain
Morning stiffness
Weakness/change in sensation
Where pain going to
Other joints
Red, swollen
Fevers/rigors/swetas/weight loss
Functional status, occupation,
Bowel / bladder /saddle anaesthesia
Recent travel, recent infection with urethritis and conjunctivitis
Abdominal pain, hernia, Back pain, Numbness
Pain with exertion relieved by rest with cool peripheries, ulcers on legs
DVT, Clotting issues
Respiratory / urinary symptoms
Autoimmune disease

Ix
Joint aspirate
FBC, CRP - infection
UEC - baseline prior to NSAIDs
LFT - ALP
Uric/CMP - gout/pseudogout / PTH
RF/Anticcp
Vitamin D

X-Ray
USS
CT/MRI

57
Q

Knee pain

A

DDx
Patellofemoral syndrome
Patellar tendinitis
Quadriceps tendinopathy
Osgood-Schlatter disease
Meniscus
MCL
Pes anserine
IT band
Baker’s cyst
Hamstring

Other
Arthritis - OA, Septic, RA, inflammatory, reactive
DVT / Popliteal arter entrapment
Gout / Psuedogout
Metastases, MM
PVD

Hx:
SOCRATES
Pivot / contact injury
Red /fevers/rigors/sweats/untentional loss of weight/warm knee
Pop sound
Swelling
Locking/clicking
Worse with stairs/squatting OR jumping
Runner / occupation
Morning stiffness, crepitus, worsens with activity or sitting
Knee extension
Bilateral / systemic symptoms / other joints / skin changes / nail changes
Recent illness including GI/GU with conjunctivitis and urethritis
Previous gout / issues with kidney stones
Shooting pain / weakness/change in sensation / cool peripheries
DVT / clotting / calf
Pain on walking / CVD / Lipids/diabetes
Hypothyroidism related pain
Neck mass / constipation / confusion

EXAMINE:
Neurovascular + joint above and below
Consider ABI

Ix:
BSL, Joint aspirate
FBC, CRP infection
Anti-RA + Anti CCP
Blood cultures
CMP, uric acid
ANA/DsDNA, HLAB27
HBA1c
Vitamin D
TSH
LFT - ALP for bony mets
USS / X-ray
MRI

58
Q

Shoulder pain

A

Ddx - Rotator cuff pathology, biceps tendonitis, arthritis (OA, septic, RA), inpingment, deletion, AC, Clavicle fracture, nerve entrapment, referred pain from neck, frozen shoulder (diabetes and hypothyroidism), polymyalgia rheumatic, cardiac, gallbladder, lung
Thoracic outlet syndrome - first rib
Thrombosis / aneurysm

HX:
SOCRATES
Trauma/overuse
Night pain
Morning pain
Stiffness
Other joints
Overhead activities
Occupation
Previous dislocation
Functional activities?
Clicking
Numbness/weakness/change in sensation
Facial flushing when raise arms up
Drooping eyelid
Fevers/rigors/sweats/unintentional loss of weight
Chest pain / SOB / diaphoresis / issues with gallbladder / skin yellow
Cough / Issues with lungs / Smoker / Recent
Cool arm / weak pulses / clotting issues
Diabetes . Hypothyroidism/ Lipids/ Hyperthyroidism
laparoscopic surgery

EXAMINE + shoulder + neck/elbow/neurovascular assessment

Ix:
Joint aspiration / BSL / ECG (ensure no cardiac cause)
FBC, CRP if infection
Troponin if indicated
X-ray
Consider TFT + HBA1c
USS / MRI after that
Nerve conduction studies

59
Q

Foot pain

A

Ddx:
Heel pain - Plantar fasciitis, Achilles tendonitis, calcanea stress fracture, tarsal tunnel
Arch/midfoot - flatfoot, lisfranc, tibialis posterior dysfunction, stress fracture
Forefoot - morton’s neuroma, stress fracture, metatarsalgia
Toe - Gout, bunion, hammer toi, freiberg
Generalise - Peripheral neuropathy, arthritis, vascular, infection, reactive

Hx:
SOCRATES
Trauma / fall / twisting injury
Weight bear?
Fevers/rigors/sweats/Unintentional weight loss/redness/swelling
Other joint pain
Morning stiffness / worse on movement / exertion / improves with activity?
Worse with weight bearing?
Tight shoes?
Sudden pain, previous gout or pseudo gout
Diabetes / Alcohol intake / Smoker
Foot drop / weakness / change in sensation / tingling
Any skin lesions
Any conjunctivitis / urethritis / recent viral infection
Autoimmune disease
PVD / CVD/ HTN/LIpids
DVT/clots/PE

EXAMINE

Ix
BSL / wound aspirate if indicated / wound mCS
FBC, CRP infection
UEC, CMP - electrolyte related
X-Ray - trauma, arhtiritis
MRI - if soft tissue/stress fracture
USS for DVT/PAD

60
Q

Sciatica

A

Ddx
Lumbar spine pathology - Herniated disc, spinal stenosis
Nerve entrapment - diabetic neuropathy
MSK - SI joint dysfunction, hamstring pain, hip pathology
Vascular - PAD, DVT
Referred pain - Hip osteoarthritis, pelvic tumour, endometriosis
Metastatic cancer / primary cancer
Localised infection
Trauma
Hypothyroidism

Hx
SOCRATES
Sharp, radiating pain
Worsening with bending or improving with lying down
Worsen with walking relieved by bending forward
Radicular symptoms
Bilateral leg weakness / urinary retention / saddle anaesthesia / constipation
Aggravated by sitting
Burning / tingling / numbness / stocking-glove pattern
Foot drop / lateral leg numbness / worse with prolonged crossing legs
Diabetes / nutritional deficiency / alcohol use
Muscle strain / over-use of muscles
Infection / trauma / skin cut / pus
Issues with hip joint or any other joint
Leg pain with walking, CVD, Relieved by rest or hanging leg over bed
Unilateral calf swelling, pain, redness, DVT/PE, Clotting issues
Abdominal pain / fevers / rigors/swetas/unintentional loss of weight
Endometriosis? - cyclic pain and pain before menstruation
Other cancers - previously treated
Hypothyroidism?
Any issues with lung / prostate / liver / bowel - systems review
Renal disease / neck mass - hyperparathyroidism

EXAMINE - straight leg test, FABER, ABI

Ix:
BGL
X-ray spine vs MRI
EMG
Doppler USS
FBC, CRP - infection / autoimmune disorder
Vitamin - B12 if alcoholic or HBA1c
UEC, CMP - muscle spasm
LFT - for ALP
Blood cultures if sepsis
RA Anti-CCP
TSH

61
Q

Intermittent claudication

A

Ddx
Vascular - PAD, Popliteal artery entrapment, buergers - ensure not CLI
Neurological - spinal stenosis, sciatica, cauda equina
MSK - Chronic extensional compartment, myositis, tendonitis
Venous- Chronic venous insufficiency, DVT
Haematologic - Sickle cell, polycythemiae, Electrolyte
Other rare - cystic adventitial, iliac artery endofibrosis

Hx:
SOCRATES
Leg pain with exertion
Diminished pulses ,cool peripheries
Smoker, raynaud’s, unilateral vs bilateral
Diabetes, HTN, Lipids
Relieved by lower leg vs relieved by bending forward
Radiating pain from back to leg
Sensory loss, weakness
Saddle anaesthesia, urinary retention
Proximal vs distal pain, fevers/rigors/sweats, unintentional loss of weight
Leg swelling ++, worsening with standing and improving with elevation
Previous DVT, clotting issues, PE
Recent crush injury / long lie / burn / etc.
Intermittent painful crises in other areas too, muscle cramps, weakness, arryhthmia, sickle cell disease in family
Occupation / Endurance athlete

EXAMINE make sure not compartment syndrome
- Normal resting pressure <10mmHg

If resting pressure >30-40 then diagnostic OR Delta P <30mmHg (Diastolic - Compartment = Delta P)

Ix:
ABI, ECG + BSL if vasculopathic
FBC, CRP - inflammatory
Blood film sickle cell
UEC, CMP ensure not metabolic disturbance cramp
Doppler USS - arterial vs venous disease
CT angiography
Spinal MRI if spinal disease

62
Q

OA

A

Ddx
Inflammatory arthritis
RA, psoriatic arthritis, gout, pseudo gout
Septic arthritis
Hemochromatosis, acromegaly, hyperparathyroidism
SLE, Scleroderma
Reactive arthritis
Charcot joint
Mets, MM, primary bone cancer

Hx:
SOCRATES
Other joints, how long
Weight bearing joints, morning stiffness, asymmetric, worsens with activity
History of trauma, obesity, joint overuse, metabolic disorders
Fevers/rigors/sweats/unintentional loss of weight
Painless joint swelling, deformity, sensory loss
Skin plaques, auto-immune conditions
Conjunctivitis, urethritis following GI/GU infection, recent other illness, recent travel
Sacroilitis/axial stiffness
Gout / sudden severe pain
Kidney stones / constipation / neck mass / kidney issues
Issues swallowing / fingers go red easily

Ix:
FBC, CRP for infection
X-ray - joint space narrowing, osteophytes, subchondral sclerosis
Could do RF, Anti-CCP, ANA, Anti-DSDNA if suspected
Joint aspiration also possible

63
Q

Erectile dysfunction

A

Ddx
Vascular - CVD/PVD, HTN, Diabetes, Smoking
Neurological - Peripheral neuropathy, MS, Spinal cord injury, stroke
Hormonal - Hypogonadism, hyperprolactinaemia, thyroid dysfunction
Psychogenic - Anxiety, depression, performance anxiety, relationship issues
Medication induced - Anti-hypertensives, SSRI’s, antipsychotics, opioids
Structural - Peyronie/Trauma
Lifestyle - Obesity, sedentary, alcohol, drug use

Hx:
SOCRATES
Libido / Ejaculation / Situational / Morning erections / Masturbating / Able to penetrate
Onset acute or chronic
DM, HTN, Heart disease, PVD, Lipids
Weakness / change in sensation / stroke previously/ spinal cord injury
Previous surgery / trauma / radiation
Skin lesions
Fatigue, muscle loss, depression, galactoraea, heat/cold intolerance, weight gain or loss
History of depression/anxiety/stress with partner
Finish history- ask about antipyschotics SSRI antihypertensives, recreational drugs
Skin lesions / curve / painful erection
Other illnesses, fevers, sweats, rigors, loss of weight

Ix:
Testosterone
Prolactin
TSH
Glucose
Lipid
USS