Histories Flashcards

(66 cards)

1
Q

LUTS

A

Differentials:
Infective - UTI/prostatitis/in setting of stone
Benign - BPH/Stricture, constipation, Medications (Diuretics), Diabetes insipidus
Malignant - Prostate cancer / Bladder cancer (primarily trigone lesions)
Neurological - MS/Parkinson’s

History questions:
Storage
- If frequency - caffeine + water intake
Voiding
Acuity of symptoms
Dysuria/Flank pain
Fevers/Rigors/Sweats
Haematuria
- If yes –> smoking, occupational exposures, past pelvic radiotherapy
FmHx urological/breast/ovarian, bony pain, fatigue
Altered bowel habit
New medications, recent surgery
Any new weakness / change in sensation / parasthesia’s / PmHx/FmHx neurological disease or Diabetes
Previous UTI’s / Previous pelvic trauma / Previous STI’s

Investigations:
Bedside - urine dipstick, DRE, PVR, uroflow, Bladder diary
Urine MCS
Lab - PSA (if no concern of infection), FBC, Coags (if haematuria), eGFR (determine whether can do CT IVP if haematuria), CRP (if concern of infection)
Imaging - RTUS to size prostate vs CT non-con/IVP depending on Hx, MRI prostate

Treatment
Abx - 4 weeks cipro for prostatitis, 7/7 for UTI in male
Medical management - Duodart vs Tamsulosin (if concern for ED)
Operation
- Consider flexi if haematuria/microhaematuria or significant symptoms of urgency/UUI w/ risk factors of TCC (suggestive of trigonal tumour) or as part of UTI workup for younger male or if concern that there is a stricture (can also do RGUG in this case).
- Consider TURP/GLL/HOLEP/Urolift if refractory to medical management / patient preference (urolift doesn’t have retrograde ejaculation)
- TP Biopsy –> PSMA PET –> prostatectomy vs EBRT vs active surveillance vs watchful waiting vs ADT + novel hormonal agent

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2
Q

Headache/SAH
- Sudden collapsed, headache + vomiting in 31M

A

Differentials:
Intracerebral haemorrhage 2ndary to AVM, hypertensive haemorrhage, trauma
Intracranial infection - Meningitis,
Venous sinus thrombosis

Other things but not this situation:
Tumour
Carotid/Vertebral artery dissection
Giant cell arteritis - Temporal artery
Other benign causes of headache -

History:
SOCRATES
Acuity of onset of symptoms
Trigger of symptoms - before, during, after
Signs of meningism - neck stiffness, photophobia
Trauma -
Visual disturbances - brainstem compression
Weaknesses / sensory changes
Fevers/rigors/sweats
Hx of smoking / drug use / aneurysm / seizures
FmHx/PHx connective tissue disorder / PCKD
Vaccinations - meningitis/covid (venous sinus thrombosis)
Recent surgery / medical presentation / immunosuppression

Exam:
Vitals
Consciousness
GCS
Head trauma
Cranial nerve - pupillary size + reactivity + EOM –> brainstem compression
Signs of meningeal irritation
Limb weakness / sensory changes - Full neurological

Treatment:
Endovascular coiling vs Craniotomy + surgical clipping
- Coiling more favourable with narrow neck
- Coiling more favourable for posterior circulation aneurysms as difficult to access
- Coiling more favourable when active vasospasm and swelling (retracting hazardous)

Risk of vasospasm for 3 weeks following aneurysm (peaks at 7-10)
- Electrolytes, no medical complications etc. important
- Give nimodipine as per local guidelines

CSW syndrome vs SIADH
- CSW –> ANP –> reduced urinary sodium + water through kidneys (Urine Na&raquo_space;> Normal in CSF AND evidence of clinical and biochemical hypovolaemia (CVP and HCT)

CSW –> sodium and volume replacement
SIADH –> Fluid restriction

If in doubt better to treat as per CSW

Risk factors:
Prior aneurysm, smoking, cocaine, HTN, FmHx aneurysms and connective tissue disorder (e.g. Marfan)

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3
Q

Neck Lump
- 58M with 6/12 hx of neck swelling (not painful)

A

This one likely thyroid as elevates on swallowing (thyroid swellings elevate because they are enveloped by pretracheal fascia which attaches thyroid to laryngopharynx)

Thyroid Ddx:
MNG - colloid, hyperplastic, adenomatous)
Solitary nodule
- Cystic degeneration colloid
- Follicular adenoma
- Thyroid carcinoma - papillary/follicular/medullary/anaplastic
- Focal area of nodularity within Hashimoto’s

Other Ddx:
Infective
- Reactive lymphadenopathy – increase in size of the cervical lymph nodes in response to infection
- Sialadenitis
Neoplastic
- Lymphoma – a haematological malignancy that commonly causes lymphadenopathy
- Head and Neck Cancer or Salivary Gland Tumour
- Metastatic disease spread
- Skin lump, ranging from benign (e.g. lipoma) to malignant (skin cancer)
Vascular - Carotid body tumour (see below)
Inflammatory - Sarcoidosis
Traumatic - Haematoma
Autoimmune - Thyroid disease, such as Graves’ disease
Congenital
- Cystic hygroma (see below)
- Thyroglossal cyst (see below)
- Branchial cyst (see below)
- Dermoid cyst – a cystic type teratoma, form along the lines of embryological fusion, can present as midline painless lumps, more common in children and young adults

History:
SOCRATES
Duration of onset
How it has changed over time and recently
Painful/painless
Precipitating factors - recent infection
Lumps or bumps elsewhere
Dysphagia/dysphonia/dyspnoea/noisy breathing/hoarseness/haemoptysis
Fevers/rigors/sweats/unintentional loss of weight
Signs of thyroid - temperature, bowels, periods, appetite, weight gain vs loss
- HYPER - Appetite, weight loss, palpitations, bowel habit (diarrhoea), heat intolerance, tremor, nervousness, muscle weakness, anxiety, sweating
- HYPO - Cold intolerance, constipation, tiredness, poor appetite, weight gain, forgetfulness, dryness of skin, menorrhagia, anaemia, carpal tunnel
Opthalmic history - diplopia and grittiness
Smoker/alcohol/FmHx head and neck cancer/Radiation exposure (ionising radiation for acne, tonsillitis, excessive facial hair, thymic enlargement)
Immunosuppressive conditions
Change in bowel habit / nausea / vomiting

OE:
ENT
Cranial nerves
Thyroid (front, laterally and behind)
- Thrill/bruit
- Venous distension
- Pemberton + Horner
- How does it move withs wallowing
- Diffuse goitre or one side
- How does thyroid feel
- Tracheal deviation
- Lymphadenopathy
- Retrosternal extension
- Stigmata of thyroid disease
- Assess swallowing, cough, phonation
Rest of body - proximal myopathy, pre-tibial myxoedema, carpal tunnel, reflexes, thyroid acropathy, thyroid eye exam (ophthalmoplegia, lid lag, proptosis, exophthalmos, chemosis, conjunctivitis)

Ix:
TFT - TSH, T4
Thyroid anti-bodies - Thyroid peroxidase, Anti-thyroglobulin, TSH receptor antibodies
CMP
Nuclear scanning of thyroid nodule - limited role
USS +/- FNA (low false negative for FNA, non-diagnostic 5-10%)
- Irregular margin, micro-calcification, solid rather than cystic, vascularity centrally
- Lymph nodes

If FNA shows follicular lesions that are indeterminate –> hemithyroidectomy for tissue diagnosis –> proceed to total if required (10-20% malignant from tissue diagnosis)

If papillary or medullary –> total thyroidectomy w radioactive iodine ablation and suppressive thyroxine (most tumours are TSH dependent)

Risks
- Bleeding, infection, pain
- Damage to RLN, EBSLN, trachea
- Hypocalcaemia rare (2 functioning glands in each side of neck)

Prognosis
- Follicular 85% 10 year survival - check with nuclear scanning, USS, and Thyroglobulin levels
- Papillary -
- Anaplastic -
- Medullary -

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4
Q

NOF

  • 85yo post fall
A

Ddx:
Fracture - pelvis or hip
Haematoma alone
Muscle tear
Ligament / tendone
Intra-abdominal

History:
SOCRATES
MIST
Before, during, after
- Rule out cardiac causes if required
Loss of consciousness / head strike
Able to mobilise after
Cuts - tetanus
Any witnesses
Previous injuries to that area
Other injuries or places where it hurts
Any recent illnesses
Change in neurology
PmHx - OP, cancer, etc.
Fasting

Ix:
CT

Tx:
Fascia-iliaca / femoral nerve block
Analgesia - multi-modal
Usually operative management - arthroplasty
Delirium preventative measures
Laxatives

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5
Q

RLQ Pain

A

Ddx:
Bowel - Meckel’s, Appendicitis, malignancy constipation, IBD, hernia, bowel obstruction, ileitis
Gallbladder/Liver possible
Urinary- Renal colic, other kidney pathologies
Gynae - Ovarian cyst rupture, ectopic pregnancy, other gynae pathology
Vascular - Mesenteric infarct
MSK - Abdominal strain
Other - mesenteric adenitis

Hx:
For each of the systems as above

Ix:
Beta-HCG, urine dipstick + MCS
Bloods - FBC, UEC, CRP, LFT
CT -

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6
Q

Portal Hypertension

A

Portal hypertension DDx
Liver related:
Pre-hepatic - Right sided heart failure, constrictive pericarditis
Hepatic - Cirrhosis vs non cirrhosis causes (schistosomiasis, sarcoid, granulomatous), Portal vein thrombosis, Budd-Chiari
Post-hepatic - Splenic vein thrombosis, biliary pathology

Systemic related:
Coagulopathy
Drugs
Nodular hyperplasia

Hx:
SOCRATES
Acute vs chronic
Yellowing of skin and eyes
Encephalopathy, infection, vomiting blood
Swelling in legs or tummy
Easy bruising or bleeding
Unintentional weight loss
Fevers/rigors/sweats
FmHx liver disease/clotting issues
Full after eating
Alcohol, hepatitis, autoimmune disease, fatty liver, iron, copper
Travel/Live to Africa or recent other travel
Issues with heart
Sexual and drug history

Ix:
FBC, UEC, CRP, LFT, Coag - could consider thrombophilia panel, could also consider AFP
Need USS
CT may be required
EUS or MRI

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7
Q

AAA

A

Pain, hypotension, pulsatile mass

Ddx:
Renal colic
diverticulitis
bowel ischaemia
Degenerative disc disease
Ovarian torsion

Abdominal / back pain - pain radiating to back
- How long for
- Any sudden change
Any evidence of leg pain on walking distances
Ulcers / infections / blockages on legs
Hx of hypertension, smoking, FmHx of aneurysm, lipids, diabetes
Marfan’s, ehler’s danlos - joint dislocations, hyperextensivity, issues with eyes, collapsed lung
Other vascular - heart disease, carotid disease etc.
Previous staph, syphilis infections

Think about AMPLE

Exam:
Looking for marfanoid appearance, pulsating abdomen, obviously ischaemic legs, sweating, pain
Observations - would want to make sure not in shock
Go straight to abdomen - will do rest of body after
Inspect - no pulsatile mass
General palpation
Two hands to see if can palpate in inspiration if fat for the aorta
Then do aorta and iliac bruits
Going to legs then heart and face
Femoral artery palpation, popliteal, DP, PT, CRT, observe for any ischaemic ulcers, make sure nil stigmata distal emboli
Heart , pectus excavatum/carinatum
Neck - carotid, carotid bruit

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7
Q

Ischaemic limb:

A

Ddx
Vascular causes
ALI - embolisim, thrombosis, trauma
CLI - atherosclerosis, vasculitis, vasculopathy from radiation

Non-vascular causes
Compartment syndrome
Nec fasc / cellulitis
DVT causing venous gangrene
Spinal cord pathology
Vasospastic disorder
Cold exposure / frostbite
Gout
Septic arthritis

Hx:
Pain where
Any other regions
Is it on walking and relieved by rest
How long walking
Any night pain, specifically anything that wakes you up from sleep
- If calf pain but no foot pain potentially not ischaemic pain (worst supplied regions should be painful)
If night pain - relieved by standing up and going for walk or hanging leg off bed
Any fevers/rigors/sweats
Any smoking history
Diabetes, lipids, HTN, heart disease/stroke
Pax FmHx - renal failure, hypothyroidism, gout
Other medical conditions
Anaesthetic history
Drug history and allergies
Social history - related to rehab

Ask questions about neurological causes
Ask about mechanical causes

EXAMINE + ABI of not CLI

Ix:
BSL at bedside, prudent ECG as well if vasculopathic
FBC, UEC, CRP, Coag
CT angiography / Doppler USS / Angiogram+/-plasty

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7
Q

Groin lump

A

Should The Children Ever Find Lumps Readily

Size/site/shape/surface/skin changes/symmetry/scars
Temperature/tenderness/transillumanability
Colour/Consistency/Compressibility
Edge/Expansility and pulsatility
Fluctuation/Flud thrill/Fixation
Lymph nodes/Lumps elsewhere
Resonance/Relations/Neurovascular status

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8
Q

Ambulance Handover

A

IMIST + AMPLE

Identity of patient
Mechanism and time
- speed, what hit, anyone else
Injuries
Signs and symptoms and how they are faring
- A, B, C, D, all obs
- Any LOC, self-extrication, walking on scene
Treatment they have done

AMPLE / AMBO

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9
Q

Dysphagia

A

Ddx:
Mechanical vs coordination

Intra-luminal, luminal, extra
motility vs neuro

Intra - Foreign body, oesophageal web, plummer vinson

Luminal - Cancer, oesophagi’s, barrett’s, benign stricture, chemical stricture

Extra - Retrosternal goitre, lung cancer, pharyngeal pouch, head and neck cancer

motility - spasm, achalasia
neuro - MG, bulbar palsy, cerebrovascular accident - 9, 10, 12 or coordination difficulty

Hx:
Liquids, solids, both - which started first
Sudden vs gradual, how long
Does it get stuck, does it feel like difficult to swallow - where is the difficulty
Regurgitate?
Full meal?
Where does it feel like food gets stuck
Any pain or painless (if pain cancer vs infection/ulcer)
GORD/reflux
Weight loss or chest infection?
Thyroid disease symptoms or previously
Any auto-immune / allergy related conditions
Any radiation / surgery / endoscopy / smoking
FmHx

Investigations:
FBC - eosinophils, WCC
EUC - baseline b4 PPI, sometimes electrolyte abnormalities
TFT if suspicion thyroid
Iron studies - if anaemic / plummer vinson
CRP - If infection
CMP - Para-neoplastic - also b4 PPI
Barium swallow, FNE, Endoscopy
CT oral contrast depending on presentation

More
H pylori infection

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10
Q

Haematemesis

A

Ddx
PUD
Variceal bleeding
- Other bleeding from rectum, ascites, jaundice, etc.
Tumour
- Constitutional symptoms
Mallory weiss - N+V excessive
Systemic cause of bleeding

Ensure not haemoptysis!!!

Prior to vomiting blood were they vomiting at all / nauseous
Do they normally have dyspepsia / chest pain before or after eating
Any malaena or change in bowel habit
Any recurrent use of NSAIDS or aspirin
Any diagnosed liver disease, have they ever noticed they were yellow
Any haemorrhoids, distended abdomen, easy bruising
Immunisations / needle use / alcohol intake / smoking
Any fevers/rigors/sweats/weight loss
Previous medical history, anaesthetic risk, allergies
Social and family history

If they are confused more likely hepatic encephalopathy as ammonia from urea not being metabolised adequately

Terlipressin for splanchnic vasoconstriction reduce flow through portosystemic shunt

Code blue and call on call endoscopist
ABCDE - need to intubate urgently to protect airway
Oxygen +++
Massive haemorrhage protocol, 2 wide bore IV, terlipressin, try and avoid over filling –> raises portal pressure and promotes further bleeding (better to give blood itself and aim for CVP 6-10, Pulse <100, Systolic >100 / MAP 65
May need to consider lactulose etc. if encephalopathic - keep monitoring
IDC for fluid status monitoring, ensure doesn’t become coagulapathic from massive haemrrhage
Must commence IvAbx as this prevents late septic complications
Sepsis may even sometimes (from SBP) lead to increased portal venous flow and lead to the variceal bleeding

When stable - focussed assessment including chart review, history, examination and then formulate plan

IR can consider TIPPS / embolisation if EBL not helpful

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11
Q

Hoarseness of voice

A

Consider - Oesophageal mass, Lung mass, otherwise could be primary throat/RLN issue from neck mass or thyroid mass

Could also be haematological or iatrogenic

Ddx
Infectious - Laryngitis, Croup, Laryngeal TB, Candida
Structural - Vocal cord nodule, HPV, Trauma, Paralysis of cord
Neurological - RLN palsy, Vagus nerve lesion (stroke, tumour), Parkinson’s disease, MG, ALS
Malignant - Cancer of larynx, thyroid, lung and oesopaghus
GI - Reflux, functional dysphonia
Endocrine - Hypothyroidism

Hx:
SOCRATES
Acute vs chronic
Intermittent or persistent
Dysphagia, dysphonia, SOB, Cough
Coughing up blood, progressive worsening
Lump
Fevers/rigors/sweats/unintentional loss of weight
Alcohol, smoking
Vaccinations, recent infection, TB previously
Reflux
Trauma
Weaknes/changee in sensation - FmHx neurological disease or cancer of larynx, thyroid or parathyroid, head and neck, oesophagus, blood
Heat/cold sensitivity, fatigue, weight gain, loss of hair, dry skin, palpitations or tremor
Easy bruising, lots of infections, anaemia
Immunosuppressed

EXAMINE

Ix:
FBC, UEC/CMP, TFT, CRP
USS if lump +/- FNA etc.
Could do CXR
Endoscopy/Laryngoscopy
CT for staging

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12
Q

Varicose veins + venous ulcer

A

Hx:
Previous DVT
Recurrent varicose veins / previous treatment
Stroke with weakness, neuromuscular disease
MSK injury of the area
Any abdominal pain, PR bleeding, PV bleeding
Any abdominal congestion, fevers/rigors/sweats

KTW syndrome PW syndrome

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13
Q

Raynauds

A

Ddx BADCAT

Blood disorders (polycythaemia), arterial drugs (BB, OCP), connective tissue disorders (RA, SLE, Scleroderma), Trauma

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14
Q

Thyroid history

A

Hyper
Increased appetite with loss of weight
Preference for cold
Increased sweating
Proximal myopathy with wasting and weakness
Diarrhoea + Frequency
Thacycardia + AF
Ameno/oligomenorrhea
Nervousness/irritability
Fine tremor

Hypo:
Weight gain and decreased appetite
Preference for hot weather
Dry skin, loss of hair
Muscle fatigue
Constipation
Bradycardia
Menorrhagia
Slow thought, depression, dementia
Symptoms of carpal tunnel syndrome

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15
Q

Causes of ptosis

A

Unilateral -
3rd nerve palsy
Horner’s - partial
Syphilis

Bilateral
Congenital ptosis
Myopathies - MG, dystrophia myotonica
Syphilis

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16
Q

Salivary gland tumour

A

Ddx
Benign - pleomorphic adenoma, warthog’s tumour, basal cell adenoma,
Malignant - Mucoepidermoid, adenoids cystic, acidic cell, carcinoma ex pleomorphic adenoma, SCC, lymphoma, metastatic
Mimicers - Sialadenitis, sialolithiasis, sjogren’s, IGG4 related disease, Sarcoidosis

Hx:
How quickly growth and pain
Any pain with eating
Any warmth or hot skin
Hard consistency vs soft
Fixed to skin
Weakness in muscles of face
Sensation near ear (greater auricular nerve) or face
Pus?
Dry mouth, dry eyes
Autoimmune diseases or connective tissue disease (RA, SLE)
Fevers/rigors/sweats/unintentional weight loss
Smoking history
Radiation
Other past medical history
Immunisations
Bruising/infections/known other cancer
Skin cancers - history of being in the sun a lot

What is Sjogren’s syndrome?
* Autoimmune condition - 90% occur in women at an average age of 50 years
* Intermittent or constant swelling of one or all of the salivary glands
* Clinical diagnosis if at least two of the following triad is present:
Keratoconjuctivitis sicca (dry eyes)
* Xerostomia (dry mouth)
* Associated connective tissue disorders
such as rheumatoid arthritis (50% of cases), scleroderma, systemic lupus erythematosus, polymyositis or polyarteritis nodosa
* If no associated connective tissue disorders are present, this is known as primary Sjbgren’s disease (note that Mikulicz syndrome is enlargement of the salivary and lacrimal glands secondary to sarcoidosis, lymphoma or tuberculosis, associated with dry mouth and dry eyes, but no arthritis)
* Pathology is lymphocyte-mediated destruction of the exocrine glands secondary to 8-cell hyper-reactivity and associated loss of suppressor T-cell activity
* Patients are at 40x increased risk of developing lymphoma, usually 8-cell non-Hodgkin’s type
* Several antibodies present, e.g. anti-salivary antibodies, rheumatoid factor, but two specific antibodies present - anti-SSA-Ro and anti-SSS-La

EXAMINE

Ix:
USS +/- FNA
CT/MRI for staging or to check facial nerve involvement
Autoimmune panel if Sjogren’s (ANA, Anti-RO/LA) + IGG4
Swab culture
FBC, CRP

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17
Q

Digital clubbing

A

Ddx

Gastro - cirrhosis, IBD, Malabsorption, lymphoma
Resp - Bronchial SCC, Lung disease (CF), Fibrosing alveoli’s, Mesothelioma
Cardiac - Cyanotic congenital heart disease, IE, Atrial myxoma
Rare - Familial

Cause - Multifactorial - TNF, Vagus affected, increased growth hormone, vasodilatation of nail-bed vessels secondary to unidentified factor which normally inactivated in lung, platelet precursors fragmented within pulmonary circulation - trapped in peripheral vasculature

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18
Q

Surgical jaundice

A

Pre, hepatic, post

Ddx; post op
Haemolysis from transfusion
Hepatic- anaesthetics, sepsis, intra/post operative hypotension
Post - bile duct injury

How long have you been yellow for
Any weight loss/appeitite/back pain
Fevers/rigors/sweats
Immunisations
Stool/urine
Pruritus
Foreign travel, recent blood transfusion
Alcohol
OCP/Phenothiazines
Drug use
Previous surgery - gallstones

Acuity of symptoms onset and then
Start with - any pain at all or any pain around meal-times
Any fevers/rigors/sweats
Previous gall bladder surgery or gall stones
Any change in bowel habit, PR bleeding
Any dark urine at all
Any itching
Any fatigue and unexplained loss of weight
Have you got any known liver disease or disease of the blood
Any recent blood loss or blood transfusion
Then ask about travel, IVDU, alcohol, sick contacts, unsafe sexual practices, tattooing or body piercing, recent illness, recent new medications
Any autoimmune diseases
Smoking, Pmhx, allergies, social history and family history

Ix:
At a minimum
Urine if dark urine make sure not haematuria
FBC - platelets, wbc
UEC - hepatorenal, urea, baseline
LFT - differentiate between cause
CRP - inflamattory/infective
Liver USS
Can do serology, AFP, other tumour markers, liver screen etc. depending on Hx
CT also depending on Hx including quad phase

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19
Q

Duputreyns

A

(a) What i s your differential diagnosis?
The differential diagnosis includes:
* Skin contracture - look for scar from previous wound
* Tendon contracture - thickened area, which moves on passive flexion of involved finger
* Congenital contracture of the little finger - affects PIPJ
* Ulnar nerve palsy - ring and little fingers are hyperextended at MCPJ and flexed at PIPJ.

Describe any tethering or pitting of the skin on the palmar aspect of the hand, and also note the appearance of any visible cords Look for scars from previous surgery
*
* Describe any flexion deformities at the metacarpophalangeal and proximal interphalangeal joints (MCPJ and PIPJ) of the involved fingers

  • Look for involvement of the thumb and the first web space (a sign of more aggressive disease)
  • Ask the patient to turn his hands over to look for Garrod’s pads (thickening of the subcutaneous tissues) over the PIPJ.
    Feel
  • Palpate the swelling, particularly noting its fixation to skin
  • Does the other palm have similar thickening? Move
  • Assess the range of motion in the involved fingers
  • Note the presence of fixed deformities by passively moving the involved joints.

(b) What conditions are associated with
Oupuytren’s contracture?
We have found the following mnemonic helpful to remember the associations - DEAFEST PAIL:
Diabetes mellitus Epilepsy
Age (positive correlation) Family history (autosomal
dominant)/Fibromatoses*
Epileptic medication (e.g. phenobarbitone) Smoking
Trauma and heavy manual labour Peyronie’s disease (fibrosis of the corpus
cavernosum - seen in 3% of patients with
Dupuytren’s)
AIDS
Idiopathic (most common)
Liver disease (secondary to alcohol).

(a) What i s the underlying pathophysiology of the condition?
Local microvessel ischaemia is thought to result in increased activity of xanthine oxidase, resulting in superoxide free radical production that in turn stimulates myofibroblast proliferation and type Ill collagen formation. Specific platelet-derived and fibroblast growth factors also play a role in the aetiology. Allopurinol, which inhibits xanthine oxidase, may help to reduce symptoms.
The process of chronic inflammation is thought to be essential to the subsequent fibrosis (see Further reading).

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20
Q

Carpal tunnel

A

DDx
* Anatomical abnormalities:
* Bone - previous wrist fractures, e.g.
Calles fracture, acromegaly
* Soft tissues - lipomas, ganglia
* Physiological abnormalities:
* Inflammatory conditions - rheumatoid arthritis, gout
* Alterations of fluid balance - pregnancy, menopause, hypothyroidism, obesity, amyloidosis, renal failure
* Neuropathic conditions - diabetes mellitus, alcoholism.
*Overuse / idiopathic

(b) Name one investigation you might perform before offering this lady treatment?
Nerve conduction studies:
* Symptoms of carpal tunnel syndrome can be mimicked by higher (more proximal) lesions of the median nerve. These high lesions are characterized by loss of sensation over the thenar eminence due to involvement of
the palmar cutaneous branch, and loss of the relevant forearm flexors (especially flexor pollicis longus)
* Symptoms may also be due to cervical nerve root lesions (e.g. secondary to a cervical disc herniation) or thoracic outlet syndrome
* Nerve conduction studies also assist in determining the severity of the lesion.

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21
Q

Lumbar disc

A
  • Age
  • Occupation
  • Features of the pain, especially site,
    radiation, any history of injury, and relieving
    and exacerbating factors
  • Neurological symptoms (e.g. weakness, numbness and paraesthesia) and their distribution
  • Sphincter disturbance - bladder and bowel symptoms (unlikely in patients used for examination purposes)
  • Effect on patient’s lifestyle, e.g. work, sleep
  • Previous treatments, e.g. use of analgesia, physiotherapy, caudal epidurals, operative
    intervention
    Explore other causes of back pain, e.g. diseases of the pancreas, abdominal aortic aneurysm, loin pain from renal causes.
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22
Q

Breast Lump

A

DDx
Benign - Fibroadenoma, breast cyst, fibrocystic change, lactational adenoma, lipoma, phyllodes tumour, hamartoma
Malignant - Ductal carcinoma, lobular, inflammatory breast cancer, paget’s disease of the nipple, phyloddes
Inflammatory - Mastitis, abscess, necrosis, mondor’s disease, granulomatous mastitis

Hx
SOCRATES
Lump history, lymph node history
Nipple discharge
Skin changes to breast
Risk factors
Menstruation early, late menopause, late age of first pregnancy or no pregnancy
HRT
Family history - BRCA? other cancers?
Fevers rigors sweats
Weight loss, back pain, shortness of breath
Autoimmune/Inflammatory diseases
Trauma, irritation, cream, allergy of skin anywhere else
Other health issues, allergies
Previous surgeries, anaesthetic risk
Social history, profession, requirement for reconstruction

Triple - Exam, USS +/- FNA, Mammogram —> Core biopsy/excisional biopsy –> definitive treatment +/- hormonal treatment

Mammography concerning features =
Mass of increased density
Ill defined margins
Speculated stellate architecture
Miicrocalcifications
Distortion of breast anatomy

extensive DCIS component, multi-focal disease, patient preference reasons for not sparing breast procedure, previous collagen vascular disorders

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23
Burn history
IMIST from ambulance What burnt patient - fire, electricity, oil, gas Duration of contact Ignition of clothing? Closed environment? ALOC VIolent movement / trauma associated when falling What PPE worn AMPLE ABCDE - EMST Want to do secondary survey + assess which burns are deep dermal or full thickness, or partial derma Capillary vasodilatation and recruitment closed capillary loops --> major extravasation of plasma to all interstitial tissues --> persists in areas under burn --> shock Deep tissue death + vascular thrombosis = worsens this Compartment syndrome highly likely Without skin = rapid cooling with exposure --> raise room temperature + glad wrap Bicarbonate to alkalinise urine making pigments water soluble (haemochromogens) 4thj degree = deep to subcutaneous fat Watch for ARF and sepsis
24
PR Bleeding
Ddx Lower GI - Haemorrhoids, fissure, diverticular, CRC, angiodysplasia, proctitis (radiation, IBD, infection), ischaemic colitis Upper GI - PUD, varices, fistula Small bowel - Crohn's, Meckel's, GIST/Carcinoid/Adenocarcinoma Vascular - Coagulopathy, thrombocytopenia, HHT Hx: SOCRATES Where when how often blood Painful/painless/colour Chronicitity Mucous/pus Diarrhoea/frrequency Constipation before episode Symptoms better or worse after food Fevers/rigors/sweats/suspicious food/unintentional weight loss Recent travel Fatigue/Dizziness on sitting or standing/Palpiations FmHx auto-immune/IBD/Cancer FOBT/Colonoscopy Recent NSAID or anticoagulant use Radiation/SMoking/Alcohol Liver disease/yellow skin H pylori/dyspepsia/ Easy bruising/bleeding elsewhere/petechiae Skin lesions Systems review MUST EXAMINE INCLUDING DRE Ix: FBC, UEC - urea, iron studies, LFT, CRP Colonoscopy CT angiography Capsule endoscopy
25
CLI DDx
Spinal canal disease Sciatia Peripheral neuropathy Risk factors Smoking diabetes, HTN, Genetic Dyslipidaemia Aetiology - Atheroscloeris, buergers, vasculitis, arterial trauma, adventitial disease,
26
Breathlessness and weight loss
DDx Respiratory - Lung cancer, tuberculosis, COPD, interstitial lung disease, pulmonary fibrosis, pulmonary embolism, metastatic cancer Cardiovascular - Heart failure, pulmonary hypertension, endocarditis Infectious - Tuberculosis, HIV/AIDS, chronic fungal infections Haem - Lymphoma, anaemia, leukaemia Metabolic/Endocrine - Hyperthyroidism, adrenal insufficiency, diabetes Autoimmune - Sarcoidosis, rheumatoid lung disease, systemic lupus erythematosus (SLE) Hx Nature and severity of shortness of breath After how much Exertion How rapidly did this develop Rest, during night, when lies flat (how many pillows, wake up sob) Cough, productive, blood Weight loss Fevers/rigros/sweats Smoking history Asbestos Family hsitory Foreign travel Family history other cancers Previous blood clots or DVT Hoarseness of voice Difficulty swallowing FBC, UEC, CMP, LFT CXR ABG Sputum MCS, AFB, Cytology
27
Hypertension
DDx: Hx: SOCRATES Rule out hypertensive crisis - irritability, headache, visual disturbances, confusion, altered consciousness, seizures Renal disease - polyuria, nocturne, dysuria, thirst, haematuria, colic, lethargy, general malaise Phaeo- sweating, palpitations, anxiety, tremor - in paroxysms Cushings - truncal weight gain, thinning of skin, easy bruising, proximal myopathy, striae, hirsutism Heart failure symptoms Back pain Chest pain NSAIDS, OCP, HTN drugs, Steroids, Antidepressants Tobacco, alcohol, illicit drugs Family history Known renal disease, pre-eclampsia when pregnant, known arterial disease Thyroid disease
28
Collapsed young man
Ddx - head trauma, tumour, mets, stroke, CNS infection, metabolic disorder - hypoglycaemia, hyponatraemia, hyperclacaemia, medication, drug withdrawal Risk factors - non-compliance, viral, abuse of alcohol, sleep deprivation How did seizure start, any aura Any focal or lateralising features at seizure onset Seizure duration Time taken to recover What happened before, during and after Any witnesses FmHx, associated symptoms (fevers) Past history head trauma, neurological illness, cardiovascular, cancer, drug and alcohol consumption
29
Leg weakness / foot drop
FINISH THIS Sudden onset or gradual Any associated pain at all Any preceding trauma, stretch, peripheral nerve injury Any weakness in any other limb or region on the same side Any back pain Any symptoms on the other side as well Any fevers/rigors/sweats Any unexplained weight loss Any headache, any nausea or vomiting - particularly in the morning or when's training Any seizures Any visual symptoms, weakness, numbness anywhere else, Bowel and bladder disturbance Any autoimmune disease Any immunosuppression or diabetes Family history of anything to do with brain, norves, brainstemV
30
Vertigo
Need to distinguish whether they are lightheadded for which Ddx - Cardiac arryhtmia, postural hypotension, anaemia, hypoglycaemia, loss of consciousness (syncope or epilepsy) Otherwise vertigo - world spinning around them - spontaneous, recurrent, changes in posture Need to clarify whether peripheral or central - vertebrobasilar ischaemia, dyelinatioatn, cerebellar disease, migraine, vasculitis CNS, neuromyelitis optica - temporal lobe epilepsy - cerebelloponine angle tumour - deafness, ataxia, facial sensory loss Peripheral - BPPV, vestibular neuronitis, meniers disease, middle ear dieseae Vestibular apparatus vs vestibular nuclei and connections Hearing loss Vision loss, Tinnitus New weakness / change in sensation / difficulty walking or balancing What brings on symptoms How long for Fevres/rigors/sweats Headache or any pain N+Vomiting, tongue biting or incontinence Cardiac risk factors and diseases Family history and personal history of any neurological diseases, migraines, tumours FINISH THIS
31
Back
DDx Vascular - Intermittent claudication - Chronic venous insufficiency MSK - Joint disease - Muscle/ligament injury - Stress fracture Neurogenic - SCiatica - Spinal canal stenosis - Cauda equina syndrome How long Any associated pain Is it shooting - how far down does it go (if not further than knee probs not sciatica) Any associated weakness / change of sensation Any bowel or bladder changes Any fevers/rigors/sweats , recent infection Any loss of weight, constitutional symptoms, neurological disease/tumoru FmHx Any clots / vascular issues Cardiac issues Hx FINISH THIS
32
Joint History approach
Site Quality Severity - effect on life Time course ?insidious Context - recent illness, STI, trauma, travel Aggravating factors Relieving factors Fevers/rigors/sweats Sensory/Weakness Sore throat Weight loss Headache Gait disturbance Rashes ulcers Genital discharge Dysuria Sicca symptoms Raynauds Diarrhoea Autoimmune, IBD, OP, bleeding disorder IVDU/smoking/eTOH Occupation
33
Constipation
Structural - associated pain, bulge, constitutional symptoms, onset, family history - Hernia - Cancer - Appendicitis - Intusseception - IBD? Dietary - Alcohol - Caffeine - Dehydration Medications - Opioids - Anti-histamines - Laxative use - Anti-diarrhoeals Metabolic/Endocrine - Hypercalcaemia - Hyperparathyroidism - Hypothyroidism Neuromuscular - Parkinson's - Cauda Equina Congenital - Hirschprung's - Cystic fibrosis FINISH THIS
34
How to differentiate between ulcers
DDx Arterial Neuropathic Pressure Venous Other Ddx same as leg laceration Hx: SOCRATES Location, pain Leg swelling, aching, heaviness, itching Varicose veins, DVT, obesity, prolonged standing, previous venous surgery Severe pain worsening with elevation, claudication, rest pain, cold feet Smoking, diabetes, hypertension, dyslipidaemia, PVD, Painless, numbness, tingling, burning Diabetes, alcoholism, spinal cord disease Fevers/rigors/sweats Immobility, malnutrition, sensory loss Exam: Location Margins, exudate Surrounding skin Peripheral pulses Capillary refill Complete neurological exam - monofilament and vibration testing Confirmatory tests Doppler USS ABI CT angiography HBA1c May require imaging to rule out deep infection such as CT
35
Leg laceration
Ddx: Traumatic Sharp force Blunt force Crush Avulsion Bite wounds Non-traumatic Infectious - Nec fasc - Cellulitis - Mycobacterial or fungal infection - Cutaneous anthrax Ulcer - Venous, arterial, neuropathic, pressure AUtoimmune/Derm - Pyoderma gangrenosum - Epidermolysis bullosa - Vasculitis - Lichen sclerosis SCC/BCC/Melanoma History: SOCRATES Foreign material, what object, how, dirty, tetanus, occupation Pain - out of proportion? Wound progressionl Walk / cold feet / neurological symptoms Anywhere else Fevers/rigors/sweats Risk factors for causes - ulcers, skin condition, skin cancer, auto-immune, derm, Unintentional loss of weibght / radiation Auto-immune Recent travel Previous TB MUST EXAMINE including neurological exam Ix: Wound swab!!, BSL at bedside!! FBC - infection UEC - Risk for PAD CRP - Inflamamtory/INfection Blood cultures - infection HBA1c - diabetic LFT - Albumin ?poor healing Autoimmune panel X-ray for gas CT? ABI/USS/ MRI for OM Punch vs excision biopsy
36
Loin Pain
DDx Renal - stone, RCC, pyelo, abscess, infarction, trauma, obstructive uropathy GI - Appendix, diverticulitis, IBD, Gall bladder, Pancreatitis Vascular - AAA, Retroperitoneal haemorrhage MSK - Muscle strain, vertebral pathology, herpes zoster Reproductive - Torsion - ovary and testicular, endometriosis, PID Neurological - Radiculopathy, spinal cord compression, diabetic Hx: SOCRATES LUTS, haematuria, dysuria Fevers/rigors/sweats/loss of weight Bowel habit, Malaena, Jaundice, Pruritus Previous surgeries of bowel, kidney, reproductive Leg pain on walking, Previous easy bruising/bleeding, anticoagulation Strain, previous issues with back, trauma, burning followed by pain and rash on one side of body Periods / scrotal pain / discharge Any trouble with sensation around anus, any weakness/change in sensation I WOULD EXAMINE Ix: Urine dip + MCS, BSL/ECG if required but unlikely FBC, UEC, CRP, LFT, Coag CT depending otherwise USS repro
37
Haematuria
Ddx: Urological TCC/Prostate cancer/RCC UTI Stones BPH Trauma Radiation cystitis Iatrogenic Schistosomiasis Non-urological Systemic - Coagulopathy, vasculitis, sickle cell Vascular - Renal artery dissection, malignant hypertension, aneurysm rupture Renal - PCKD, Glomerulonephritis Drug induced - abx, ibuprofen, cyclophosphamide Pseudo - jaundice, rhabdo, porphyria, beeturia, drugs (rifampicin) Hx: SOCRATES Painful vs painless - Smoking, occupation, exposure to paints/dyes Infective vs non-infective Constitutional symptoms LUTS Previous urological and fmHx of urological/kidney/other cancer or no cancer Pelvic radiation stones / neck mass / constipation Bleeding / bruising / epistaxis / bleeding anywhere else Trauma Travel overseas Hypertension / headache/blurry vision Medications Cough/chest infection/swelling in legs After finish Hx - do systems review --> Notice skin yellow, recent long run / long lie, eating beetroot, weakness/change in sensation Examine patient Ix: Urine dip + MCS Urine cytology x3 Urine red cell morphology FBC, UEC, CRP, Coag, PSA, LFT if suspicion of pseudo/coagulopathy, autoimmune panel if worried about auto-immune, sickle cell screening CT IVP/RTUS Flexible cystoscopy
38
Scrotal Swelling
Ddx Urological Torsion / torsion of appendage Epididymo-orchitis SCrotal trauma Fournier's Iatrogenic Tumour Kidney stone Varicocele/Spermatocele/Hydrocele Idiopathic Non-urological Hernia Parasitic infection Lymphadenopathy Oedema Hx: SOCRATES Sudden onset and when Pain and if so - Constant / coming and going Able to get over or not Testes in origin or scrotum LUTS? Haematuria? Dysuria? Fevers/rigors/sweats/unintentional weight loss FmHx cancer Trauma Flank pain / previous kidney stones Heavy lifting / previous hernia Recent overseas travel / any travel Swelling anywhere else in body Lumps or bumps anywhere else Examine!! - Able to get over / under, transilluminate, prehn, cremasteric, Ix: Urine dip + MCS Urine STI screen USS FBC - anaemia/wcc, CRP - inflammatory/infection, UEC - stone AFP, LDH, Beta HCG CT CAP if feels obvious tumour or CT AP if large hernia
39
Post op chest pain
Ddx Cardiac - MI, Pericarditis, Tamponade Pulmonary - PE, PTX, Pneumonia GI - Oesophageal rupture, GORD, PUD MSK - pre-existing Surgical - related to laparoscopy or thoracotomy etc. Anxiety LUQ Abdominal pain - Pancreatitis, Haemorrhage, Mesenteric ischaemia, splenic infarct or pain, aortic dissection, kidney stone, herpes zoster: Hx: SOCRATES Acute vs chronic Pre-op or only post op Insidious Related to breathing? Exertional? Sitting up or lying down? After or before food? SOB / cough / coughing up blood Fevers/rigors/sweats Cardiac risk factors - Previous MI, FmHx, Diabetes, Dyslipidaemia, HTN Leg swelling or pain Palpitations or dizziness especially on sitting or standing Previous blood thinners / previous DVT Ix: ECG Trop, ABG (alkalosis), FBC, CRP, Coag CXR - PTx, Pneumonia, Widened mediastinum or mediastinal air CTPA/Gastrograffin swallow Echocardiogram
40
Diarrhoea
DdX: Viral/bacterial/antibiotic/parasitic - gastroenteritis IBD IBS Cancer Bile acid diarrhoea / CLD Coeliac/Lactose/Pancreatitis related/SIBO Endocrine / Metabolic - Hyperthyroidism, Carcinoid, VIPoma, Addison's Medication induced Post surgical - short bowel/fistula/dumping syndrome Hx: SOCRATES How many stools Acute / chronic Watery/Bloody Tenesmus, fevers/rigors/sweats/unintentional weight loss Abdominal pain ?relieved by diarrhoea Recent travel FmHx CRC/IBD/Autoimmune Iron deficiency / steatorrhea, after dairy ingestion/gluten Yellow skin, pruritus, Liver disease, biliary surgery, gall bladder Tremors/AF/Loss of hair/Heat insensitivity/ Hyperpigmentation of skin and low blood pressure (dizziness on sitting and standing) Flushing/dehyrdration Antibiotics/Laxatives/PPI/Metformin Recent surgery Stool culture + MCS, calprotectin FBC, CRP, TTG IGA, LFT, UEC for dehydration, consider lipase, May require colonoscopy especially if overdue ACTH and cortisol if Addisons'
41
Abdominal pain
Ddx: RUQ - Cholecystitis, Cholangitis, hepatitis, Liver abscess, Pyelo, Kidney stone LUQ - Gastritis, PUD, Pancreatitis, Splenic infarction or rupture, Pyelo, Kidney stone Epigastric - GORD, MI, Aortic dissection RLQ - Appendicitis, Crohn's, Torsion/cyst rupture, ectopic LLQ - UC, Ovarian, Diverticulitis Generalised or vascular - Mesenteric ischaemia, AAA, Peritonitis, Cystitis, Any malignancy - Kidney, Bowel, Liver, Other Hx: SOCRAATES When start Radiate Fever/vomiting/diarrhoea/weight loss/blood in stool/change in bowel habit Previous surgeries, CVD, Smoking, NSAIDS Urinary symptoms, dysuria Medications - NSAID, Opoid Stones Gynaecological hx, urological hx Autoimmune/IBD FmHx any of above including any cancers Previous gallstones/pancreatitis Jaundice, pruritus, liver disease things Sexual hx, discharge Muscular strain Must examine!!! Including DRE Ix: FBC, UEC, CRP, LFT, Lipase CT AP
42
Haemoptysis
Ddx Respiratory PE Bronchial artery rupture Lung cancer TB Pneumonia Abscess Aspergillosis COVID, Influenza, viral pneumonia COPD SLE/Vasculitis Bronchiectasis Non-respiratory Coagulopathy. TTP AAA Mitral stenosis Heart failure Ensure not haematemesis Iatrogenic Hx: SOCRATES How much and since when Fresh or dark red Blood streaked sputum? Fevers/night sweats/weight loss Smoking, TB, Travel Surgery OCP Pleuritic chest pain, shortness of breath, leg swelling Orthopnoea, PND Nosebleeds brusing, bleeding gums, epistaxis Haematuria, joint pain, rash Autoimmune Anticoagulant EXAMINE Ix: Sputum MCS, ECG FBC, Coag, UEC (urea), CRP Depending on Hx could do D-dimer/ANCA/Anti-GBM and LFT CXR at a minimum Otherwise CT Chest/CTPA Bronchoscopy? Endoscopy?
43
Melanoma
Ddx: Skin cancers - BCC, SCC, kaposi Benign skin lesion - seborrheic keratosis, blue/spitz nevus, solar lentigo, pigmented dermatofibroma Pre-malignant - atypical naves, lentigo maligns, actinic keratosis Addison's disease, PIH, Drug eruption, tattoo Hx: SOCRATES - Raised, flat, vascular, changing with time, itchy, bleeding, crusting Trauma or irritation Sun exposure, occupation, whether wear sunscreen or not (and where), tanning bed, moles Often get sunburnt, fair skin, red/blond hair FmHx Other skin lesions Previous skin cancers Fevers/rigors/sweats/unexplained weight loss Bony pain, persistent headache, vision changes Autoimmune diseases or immunosuppression Do you feel weak, tired, episodes of fainting or light headedness on standing, hyperpigmentation, N+V or diarrhoea Systems review Ix: EXAMINE Dermascopy Excisional biopsy Could do FBC, CRP ensure not infected lesion, Coags if indicated
44
Post-operative pain (abdominal)
DDx Expected post-operative Wound and soft tissue complication - infection/haematoma/seroma/dehiscence Abscess/peritonitis/NF Post-operative haemorrhage, compartment syndrome, ischaemia nerve injury, neuropathic pain Pneumothoraxi, Bowel obstruction, urinary retention MI / PE / DVT Pneumonia Ileus Hx: SOCRATES Fever, erythema, wound discharge Dizziness sitting and standing, cool peripheries Abdominal distention N+V SOB/chest pain hypoxia Leg swelling, redness, diaphoresis Previous cardiac history if chest pain Diabetes obesity smoking immunosuppression EXAMINE - bladder scan, DRE - pelvic abscess, DVT Ix: Urine dipstick + MCS, ECG, FBC, CRP - inflammation infection UEC - post op ileus electrolyte Trops LFT - bile leak liver dysfuction Coag - DIC ABG - acidosis - ischemia, sepsis CTPA/Doppler USS Wound MCS CXR for pneumonia CT for anastomotic leak
45
DVT risk pre-op
DDx/Risk Immobilisation Malignancy Pregnancy Thrombophilia/Antiphospholipid syndrome Recent surgery Previous DVT Nephrotic syndrome Ortho/Abdominal/pelvic surgery/neurosurgery/>3 hour surgery OCP Wells - Active cancer (treatment ongoing or within 6 months) +1 Paralysis, paresis, or recent immobilization of a limb +1 Bedridden for ≥3 days or major surgery in past 4 weeks +1 Localized tenderness along deep venous system +1 Swelling of entire leg +1 Calf swelling >3 cm compared to other leg +1 Pitting edema +1 Collateral superficial veins (non-varicose) +1 Alternative diagnosis more likely -2 Virchow - stasis, hypercoagubility, Endothelial Hx: SOCRATES Leg pain, swelling, redness Immobilisation Chest pain, SOB, Haemoptysis Neurological deficits (PFO), stroke like Weight loss, night sweats, unexplained fatigue, Previous DVT PE History of clots - factor 5 protein C/S, APLS Smoking OCP, HRT Recent surgery EXAMINE Ix: D Dimer Coags Thrombophilia Venous doppler USS CTPA Echo
46
Post-operative delirium
Ddx: Infective - Pneumonia, UTI, wound, Sepsis of other cause, post-operative Metabolic - hypoxia, hypoglycaemia, electrolyte, uraemia Neurological - stroke, seizure, haematoma, pre-existing dementia Medications - opioids, benzodiazepines, anti-cholintergics, polypharmacy, alcohol withdrawal, anaesthetic related Cardiovascular - hypotension, hypertensive crisis, MI Uncontrolled pain, psychosis, surgical stress response Ensure not psychiatric, dementia, POCD Hx: SOCRATES Fluctuating or persisitent Lucid? Fever/rigors/sweats Tachycardia/cough/dyspnoea/chest pain/weakness/change in sensation/agitation/rtremors/dehydration/pain Urinary symptoms Wound Post-operative course DVT/PE Drugs given New medications previous Delirium Pre-existing cognitive impairment Bowels Systems review EXAMINE - bladder scan, DRE Ix: ECG, BSL FBC, CRP, UEC, LFT (hepatic encephalopathy) Blood cultures, CXR, Urine MCS ABG Tox screen CT Brain RTUS USS doppler
47
Pre-op bruising
Ddx: Medications - anticoagulant, anti-platelet, NSAID, SSRI, Corticosteroid Platelet disorders - thrombocytopenia, platelet dysfunction, congenital platelet disorder Coagulation factor deficiency - Hemophilia A/B, Liver disease, Vitamin K deficiency (warfarin, prolonged antibiotics, malabsorption) Vascular fragility - Euler's Danos, Marfan Systemic - CKD, Liver disease, MM Nutritional - Vitamin C and K Cushings/Diabetes/CKD/Age/Hematologic Amyloidosis/DIC sepsis related Hx: SOCRATES Spontaneous, trauma, mucosal bleeding, petechiae, haemarthrosis, haematoma Location, Epistaxis, GI bleeding, haematuria Liver disease, anticoagulants Medications CKD/Cushing's Fatigue, weight loss, fevers, rigors, sweats Weight gain, moon face, buffalo hump Skin changes Autoimmune disorder Infective signs - Chest, urine, skin - chronic infections Neurological signs? Food alcohol intake Smoking EXAMINE Ix: FBC, Blood film, Clotting, LFT, UEC - CKD, D-dimer, Von willebrand, Factor 8 and 9, Vitamin C and K Cortisol CT/Brain MRI? Abdominal USS - Hepatosplenomegaly Bone marrow biopsy
48
Projectile vomiting in child
Ddx Hypertrophic pyloric stenosis (early) Intestinal atresa Malrotation with midgut volvulus Metabolic disorder - GORD Food intolerance Infections Intra-cranial pressure Gastroenteritis Increased intracranial pressure Appendicitis Toxin ingestion Liver disesase Metabolic disorder (urea cycle defect), organic academia Hx: SOCRATES Projectile or not Bilious or not Bloody or coffee ground Feeds Morning Abdominal distension or pain/constipation Weight loss, dehydration, ltheragy Drawing up of legs Bulbing fontanelle, seizures Fever, poor feeding, irritability, neck stiffness Unintentional loss of weight FmHx cancer N+V Smelly urine, Diarrhoea, Premature, issues with pregnancy Pre-eclampsia FmHx GI issues Yello0w, scratching, EXAMINE - pyloric mass, ICP, bulging fontanelle, fluid status Ix: Glucose, urinalysis FBC, CRP UEC - electrolyte LFT, Ammonai, Gas - alkalosis = stenosis, acidosis sepsis/shock/inborn errors Bilirubin/LOFT - neonatal liver disease
49
Incontinence
DDx Stress - weak pelvic floor (previous complicated birth), cachexia, previous prostatic surgery, pelvic organ prolapse, rectal prolapse Urge - infection, detrusor overactivity, TCC at trigone Overflow incontinence - HPCUR, BOO (cancer or non-cancer) Functional incontinence - Dementia, stroke Neurological - MS, Parkinson's stroke, spinal cord injury Metabolic - DM, Hypercalcaemia with nephrogenic DI medications - diuretics, anticholinergics, opioids Mixed Hx: SOCRATES SUI/UUI LUTS - haematuria Rule out infection, fevers/rigors/sweats/flank pain/rUTI's FmHx prostate cancer / PSA Unintentional loss of weight Smoking, occupational exposures, blood thinners, pelvic radiation Prolapse of organs Pregnancy history Surgical history Weakness/change in sensation anywhere Obesity Mediations COPD/Cough Situational Stones / constipation / abdominal pain EXAMINE INCLUDING DRE and PV exam UROFLOW Ix: FBC, CRP, UEC (HPCUR), HBA1c, Calcium (hypercalcium), PSA blood test Urine dipstick + MCS RTUS + Cystoscopy MRI spine if neurological cause Further down the track urodynamics to diagnose detrusor overactivity Rule out reversible causes Pelvic floor physio Bladder training Medication - Anti-cholinergics, oestrogen, ISC Sling/botox/sacral nerve stimulation/TURP
50
Iron deficiency anaemia
DDx Blood loss - GI bleeding, menorrhagia, post surgical, haematuria, blood donation Malabsorption - Coeliac, H pylori, gastrectomy, IBD, bariatric Dietary deficiency - Vegetarian, vegan, pregnancy Increased demand - Children/Pregnancy Chronic liver disease/Crhonic kidney disease IDA Mimics - Chronic disease, thalasaemia, lead poisoning, sideroblastic Hx: SOCRATES Fatigue, weakness, exercise tolerance Dizziness on sitting/standing Pallor Pain any where? Radiating to back Bowel symptoms Bladder symtptoms Swelling anywhere Recent surgery Craving for ice/dirt/starch NSAIDS/Epigastric pain/reflux Periods! Chronic diarrhoea, GI surgery H pylori What diet RA/CKD/Chronic Autoimmune Loss of weight / fevers/rigors/sweats Recent infection Yellow/liver/kidney/ EXAMINE Ix: FBC, Iron sudies Coeliac, breath test, LFT if chronic liver disease Stool cal pro / colonoscopy/endoscopy CT AP CXR
50
Dislocated shoulder
Ddx: Anterior EXT ABD - FOOSH Posterior INT ADD - Seizure, electrocution, FOOSH Inferior ARM above - high energy trauma, hyperabduction Other causes Fractures Rotator cuff injury Labral tear AC joint Brachial plexus Septic arthritis Shoulder impingement See shoulder pain for Hx IX Important for axillary nerve and radial pulse 3 view x-ray Humeral head where is it Hill sachs - cortical defect for choronic Glenoid rim fracture - Recurrent instability CT/MRI
51
Anorexia/weight loss
Ddx Systemic/Malignancy - GI, Lung, Haematological, RA/SLE, Chronic infection (TB, HIV, Endocarditis) GI - Coeliac, IBD, Pancreatitis, PUD, gastropareasis, stricture/cancer of oesophagus Endocrine - Hyperthyroidism, Adrenal, DM, CKD Psychiatric - Eating disorder, depression/anxiety, dementia/ALS, Substance use TB/HIV/Parasite Medication - Stimulants, Chemotherapy, metformin, SSRI's Post GI surgery, Radiation heart failure COPD Hx: SOCRATES Amount Intentional vs not intentional Normal appetite but weight loss, loss of appetitie, early satiety, difficulty swallowing, painful swallowing Diarrhoea, steatorhea Fevers/night sweats/rigors Abdominal pain, rectal bleeding Tremor, heat intolerance, palpitations, skin changes including hyperpigmentation, salt craving, dementia, memory loss, weakness/change in sensation Family history cancers - lung, liver, bowel, prostate, breast, blood Alcohol, drugs, smoking Recent travel Medication - suppressant, chemo, SSRI Heart failure COPD Systems review EXAMINE including BMI Ix: FBC - anaemia, WCC infection CRP - infection, malignancy LFT - malignancy, albumin UEC - Electrolyte imbalance from metabolic, CKD CMP - malnutrition paraneoplastic TFT , ACTH, Serology (coeliac, HIV) Stool examination, culture, calprotectin CXR/Abdominal USS/CT AP Endoscopy/Colonoscopy
52
Post operative fever
Ddx Atelectasis, Aspiration, Pneumonia, SIRS, UTI, Central line, drug fever, wound, DVT/PE, C difficile, Deep surgical infection, Endocarditis, HITS Normal inflammatory response Undiagnosed malignancy/lymphoma Hx: Onset, recurrent, level Sustained, spiking Feeling of hot Rigors/sweats Cough/runny nose/sob Deep breathing post-op, sitting out of bed Dysuria/frequency/flank pain Redness, pain, discharge at wound site Diarrhoea, nausea+vomiting Leg swelling, redness of leg, calf pain, previous clot in leg Abdominal pain Mobilising Eating Rash anywhere on body Systems review Confusion? EXAMINE Ix: Urine dipstick, ECG (right heart strain) FBC, CRP - infection UEC - dehydration/kidney function in setting sepsis LFT - drug reaction Blood cultures/urine cultures/sputum culture/wound swab/Faecaes PCR CXR Doppler USS vs CTPA
53
Paediatric neck mass
Ddx Congenital - branchial cleft, thyroglossal, dermoid, cystic hygroma, teratoma Infectious (MOST COMMON) - Reactive, bacterial, tuberculous, mycobacterial, cat stretch, viral, fungal, septic thrombophlebitis, abscess Inflammatory - Kawasaki, JIA, Sarcoidosis Neoplastic - Lymphoma, leukaemia, neuroblastoma, thyroid, salivary gland tumour Vascular - AVM, Haemangioma Neuroblastoma Hx: SOCRATES Pain, onset, stable, soft/fim, mobile/fixed Fever/sore throat/weight loss/night sweats Dysphagia, hoarseness, cough, skin changes, SOB Skin changes Recent infections, travel Cat scratch/animal exposure Immunosuppresion Family history of cancer/autoimmune disease Conjunctivitis/rash Thyroid symptoms Exposure to smoking Weakness/chagne in sensation/Dizziness Bleeding bruising Ix: EXAMINE FBC, CRP - infection Viral panel / serology Throat swab / blood culture LDH / USS +/- FNA CXR
54
Supraclavicular Mass
DDx Lymphadenopathy - Reactive, granulomatous disease, lymphoma, metastatic (stomach, pancreas, colon breast on left, thoracic lung and oesophagus breast on right), leukaemia Infectious - TB, Lymphadenitis (Staph/Strep), Cat scratch, fungal, vira Congenital - Cyst - branchial or thyroglossal Vascular - Carotid body tumour, subclavian artery aneurysm, jugular vein DVT Cancer - Thyroid cancer, Salivary gland, sarcoma Goitre/Sarcodiosis Hx: SOCRATES Fixed, hard vs mobile Painful Warm/red Growing Night sweats/fevers/unintineional loss of weight/rigors Which side Sore throat, recent travel, TB, skin infections, dental infections Cough, blood, sob Difficulty breathing, N+V, early steatite, vomiting blood, maelaena Easy bruising/infections Breast lump - pain, discharge Thyroid symptoms Radiation Other malignancies Immunosuppressed Smoking/alcohol/HPylori/Reflux Weakness/ change in sensation/numbness down either arm or anywhere Cool peripheries Ulcers/skin changes Ix: EXAMINE Lymph node, thyroid, neck, abdominal, respiratory, breast FBC, CRP infection, malignancy, LFT in case GI origin, UEC - urea bleeding, baseline uec Optional TB/HIV/EBV/CMV CEA/Ca19.9, AFP, PSA, TFT USS +/- FNA X-ray if resp CT staging
55
Tongue ulcer
DDx Viral - HSV, VZV, HPV, HIV Bacterial - Syphilis, TB Fungal - Candidaisis, immunocompromised Inflammatory - Aphthous, behcet's disease, IBD, Reiter's (reactive arthritis) Benign - Papilloma/fibroma/haemangioma Premalignant - leukoplakia/erythroplakia Malignant - SCC, lymphoma, kaposi Metabolic - CKD Stomatitis, IDA/B12 Drug - Chemo/Bisphosnophate/NSAID Hx: SOCRATES How long for Healing or not Painful or painless Lymphadenopathy Fevers/rigors/sweats/loss of weight Smoking / Alcohol / FmHx cancer / Tongue Any other lumps anywhere else Immunosuppression / DM / IBD / Autoimmune disease Joint pain / issues with urinating (pain) / red eyes infected Skin lesions in genital area Final infection / viral infection Vaccinations Previous Herpes / potential new risk (new sexual contact) Previous TB / cough / sob Recent travel What medications Any cancer Dizziness sitting standing EXAMINE - Neck + ENT Ix: FBC, CRP - infection UYEC - Uraemiec stomatitis IDA/VItamin B12/Folate HBA1c Autoimmune panel potentially PCR swab / MCS / Syphilis / fungal culture Quantiferon test USS +/- Xray if dental involvement or CXR if chest CT vs MRI depending on that FNAC vs biopsy
56
Hip Pain
Ddx MSK - OA, FAI, Labral tear, Greater trochanter, AVN, Hip/Stress fracture, Muscle strain, Snapping hip, Legg-Calve Perthes, SCFE Neurological - SCiatica, Piriformis, Lumbar spinal stenosis, femoral neuropathy, meralgia paresthetica Inflammatory - IBD, RA, Gout/Pseudogout Infective - Septic, OA, Tuberculosis, Lyme Referred- Lumbar, inguinal hernia, SI joint, Pelvic (prostate appendix ovary) Vascular - Claudication, DVT Trauma Neoplastic - Primary, mets, lymphoma Hx: SOCRATES Onset Worsened by activity or better with it Clicking / locing Corticosteroid use/alcohol.trauma/deep persistent pain Morning stiffness Weakness/change in sensation Where pain going to Other joints Red, swollen Fevers/rigors/swetas/weight loss Functional status, occupation, Bowel / bladder /saddle anaesthesia Recent travel, recent infection with urethritis and conjunctivitis Abdominal pain, hernia, Back pain, Numbness Pain with exertion relieved by rest with cool peripheries, ulcers on legs DVT, Clotting issues Respiratory / urinary symptoms Autoimmune disease Ix Joint aspirate FBC, CRP - infection UEC - baseline prior to NSAIDs LFT - ALP Uric/CMP - gout/pseudogout / PTH RF/Anticcp Vitamin D X-Ray USS CT/MRI
57
Knee pain
DDx Patellofemoral syndrome Patellar tendinitis Quadriceps tendinopathy Osgood-Schlatter disease Meniscus MCL Pes anserine IT band Baker's cyst Hamstring Other Arthritis - OA, Septic, RA, inflammatory, reactive DVT / Popliteal artery entrapment Gout / Psuedogout Metastases, MM PVD Hx: SOCRATES Pivot / contact injury Red /fevers/rigors/sweats/untentional loss of weight/warm knee Pop sound Swelling Locking/clicking Worse with stairs/squatting OR jumping Runner / occupation Morning stiffness, crepitus, worsens with activity or sitting Knee extension Bilateral / systemic symptoms / other joints / skin changes / nail changes Recent illness including GI/GU with conjunctivitis and urethritis Previous gout / issues with kidney stones Shooting pain / weakness/change in sensation / cool peripheries DVT / clotting / calf Pain on walking / CVD / Lipids/diabetes Hypothyroidism related pain Neck mass / constipation / confusion EXAMINE: Neurovascular + joint above and below Consider ABI Ix: BSL, Joint aspirate FBC, CRP infection Anti-RA + Anti CCP Blood cultures CMP, uric acid ANA/DsDNA, HLAB27 HBA1c Vitamin D TSH LFT - ALP for bony mets USS / X-ray MRI
58
Shoulder pain
Ddx - Rotator cuff pathology, biceps tendonitis, arthritis (OA, septic, RA), inpingment, deletion, AC, Clavicle fracture, nerve entrapment, referred pain from neck, frozen shoulder (diabetes and hypothyroidism), polymyalgia rheumatic, cardiac, gallbladder, lung Thoracic outlet syndrome - first rib Thrombosis / aneurysm HX: SOCRATES Trauma/overuse Night pain Morning pain Stiffness Other joints Overhead activities Occupation Previous dislocation Functional activities? Clicking Numbness/weakness/change in sensation Facial flushing when raise arms up Drooping eyelid Fevers/rigors/sweats/unintentional loss of weight Chest pain / SOB / diaphoresis / issues with gallbladder / skin yellow Cough / Issues with lungs / Smoker / Recent Cool arm / weak pulses / clotting issues Diabetes . Hypothyroidism/ Lipids/ Hyperthyroidism laparoscopic surgery EXAMINE + shoulder + neck/elbow/neurovascular assessment Ix: Joint aspiration / BSL / ECG (ensure no cardiac cause) FBC, CRP if infection Troponin if indicated X-ray Consider TFT + HBA1c USS / MRI after that Nerve conduction studies
59
Foot pain
Ddx: Heel pain - Plantar fasciitis, Achilles tendonitis, calcanea stress fracture, tarsal tunnel Arch/midfoot - flatfoot, lisfranc, tibialis posterior dysfunction, stress fracture Forefoot - morton's neuroma, stress fracture, metatarsalgia Toe - Gout, bunion, hammer toi, freiberg Generalise - Peripheral neuropathy, arthritis, vascular, infection, reactive Hx: SOCRATES Trauma / fall / twisting injury Weight bear? Fevers/rigors/sweats/Unintentional weight loss/redness/swelling Other joint pain Morning stiffness / worse on movement / exertion / improves with activity? Worse with weight bearing? Tight shoes? Sudden pain, previous gout or pseudo gout Diabetes / Alcohol intake / Smoker Foot drop / weakness / change in sensation / tingling Any skin lesions Any conjunctivitis / urethritis / recent viral infection Autoimmune disease PVD / CVD/ HTN/LIpids DVT/clots/PE EXAMINE Ix BSL / wound aspirate if indicated / wound mCS FBC, CRP infection UEC, CMP - electrolyte related X-Ray - trauma, arhtiritis MRI - if soft tissue/stress fracture USS for DVT/PAD
60
Sciatica
Ddx Lumbar spine pathology - Herniated disc, spinal stenosis Nerve entrapment - diabetic neuropathy MSK - SI joint dysfunction, hamstring pain, hip pathology Vascular - PAD, DVT Referred pain - Hip osteoarthritis, pelvic tumour, endometriosis Metastatic cancer / primary cancer Localised infection Trauma Hypothyroidism Hx SOCRATES Sharp, radiating pain Worsening with bending or improving with lying down Worsen with walking relieved by bending forward Radicular symptoms Bilateral leg weakness / urinary retention / saddle anaesthesia / constipation Aggravated by sitting Burning / tingling / numbness / stocking-glove pattern Foot drop / lateral leg numbness / worse with prolonged crossing legs Diabetes / nutritional deficiency / alcohol use Muscle strain / over-use of muscles Infection / trauma / skin cut / pus Issues with hip joint or any other joint Leg pain with walking, CVD, Relieved by rest or hanging leg over bed Unilateral calf swelling, pain, redness, DVT/PE, Clotting issues Abdominal pain / fevers / rigors/swetas/unintentional loss of weight Endometriosis? - cyclic pain and pain before menstruation Other cancers - previously treated Hypothyroidism? Any issues with lung / prostate / liver / bowel - systems review Renal disease / neck mass - hyperparathyroidism EXAMINE - straight leg test, FABER, ABI Ix: BGL X-ray spine vs MRI EMG Doppler USS FBC, CRP - infection / autoimmune disorder Vitamin - B12 if alcoholic or HBA1c UEC, CMP - muscle spasm LFT - for ALP Blood cultures if sepsis RA Anti-CCP TSH
61
Intermittent claudication
Ddx Vascular - PAD, Popliteal artery entrapment, buergers - ensure not CLI Neurological - spinal stenosis, sciatica, cauda equina MSK - Chronic extensional compartment, myositis, tendonitis Venous- Chronic venous insufficiency, DVT Haematologic - Sickle cell, polycythemiae, Electrolyte Other rare - cystic adventitial, iliac artery endofibrosis Hx: SOCRATES Leg pain with exertion Diminished pulses ,cool peripheries Smoker, raynaud's, unilateral vs bilateral Diabetes, HTN, Lipids Relieved by lower leg vs relieved by bending forward Radiating pain from back to leg Sensory loss, weakness Saddle anaesthesia, urinary retention Proximal vs distal pain, fevers/rigors/sweats, unintentional loss of weight Leg swelling ++, worsening with standing and improving with elevation Previous DVT, clotting issues, PE Recent crush injury / long lie / burn / etc. Intermittent painful crises in other areas too, muscle cramps, weakness, arryhthmia, sickle cell disease in family Occupation / Endurance athlete EXAMINE make sure not compartment syndrome - Normal resting pressure <10mmHg If resting pressure >30-40 then diagnostic OR Delta P <30mmHg (Diastolic - Compartment = Delta P) Ix: ABI, ECG + BSL if vasculopathic FBC, CRP - inflammatory Blood film sickle cell UEC, CMP ensure not metabolic disturbance cramp Doppler USS - arterial vs venous disease CT angiography Spinal MRI if spinal disease
62
OA
Ddx Inflammatory arthritis RA, psoriatic arthritis, gout, pseudo gout Septic arthritis Hemochromatosis, acromegaly, hyperparathyroidism SLE, Scleroderma Reactive arthritis Charcot joint Mets, MM, primary bone cancer Hx: SOCRATES Other joints, how long Weight bearing joints, morning stiffness, asymmetric, worsens with activity History of trauma, obesity, joint overuse, metabolic disorders Fevers/rigors/sweats/unintentional loss of weight Painless joint swelling, deformity, sensory loss Skin plaques, auto-immune conditions Conjunctivitis, urethritis following GI/GU infection, recent other illness, recent travel Sacroilitis/axial stiffness Gout / sudden severe pain Kidney stones / constipation / neck mass / kidney issues Issues swallowing / fingers go red easily Ix: FBC, CRP for infection X-ray - joint space narrowing, osteophytes, subchondral sclerosis Could do RF, Anti-CCP, ANA, Anti-DSDNA if suspected Joint aspiration also possible
63
Erectile dysfunction
Ddx Vascular - CVD/PVD, HTN, Diabetes, Smoking Neurological - Peripheral neuropathy, MS, Spinal cord injury, stroke Hormonal - Hypogonadism, hyperprolactinaemia, thyroid dysfunction Psychogenic - Anxiety, depression, performance anxiety, relationship issues Medication induced - Anti-hypertensives, SSRI's, antipsychotics, opioids Structural - Peyronie/Trauma Lifestyle - Obesity, sedentary, alcohol, drug use Hx: SOCRATES Libido / Ejaculation / Situational / Morning erections / Masturbating / Able to penetrate Onset acute or chronic DM, HTN, Heart disease, PVD, Lipids Weakness / change in sensation / stroke previously/ spinal cord injury Previous surgery / trauma / radiation Skin lesions Fatigue, muscle loss, depression, galactoraea, heat/cold intolerance, weight gain or loss History of depression/anxiety/stress with partner Finish history- ask about antipyschotics SSRI antihypertensives, recreational drugs Skin lesions / curve / painful erection Other illnesses, fevers, sweats, rigors, loss of weight Ix: Testosterone Prolactin TSH Glucose Lipid USS