Historic Discoveries Exam 2

Question 1

pericyte function, regulation of SkM, diffusion, krogh cylinder

Answer 1

August Krogh

Question 2

first discovered the BBB

Answer 2

Ehrlich

Question 3

stained the brain via spinal fluid

Answer 3

Goldman

Question 4

proposed the “hematoencephalic barrier”

Answer 4

Lewandowsky

Question 5

mean transit time (MTT) equation

Answer 5

Stewart

Question 6

discovered AQPs

Answer 6

Agre

Question 7

discovered gas channels

Answer 7

Boron

Question 8

related Co2 to climate change, Q10, equation with activation energy

Answer 8

Arrhenius

Question 9

warm blooded animals in cold climates are larger in body size than relatives in warm climates

Answer 9

Bergmann

Question 10

scaling

Answer 10

Schmidt-Nielsen

Question 11

larger animals live longer than smaller

Answer 11

Aristotle

Question 12

symmorphosis

Answer 12

Weibel

Question 13

“bioblasts”

Answer 13

Altman

Question 14

coined “mitochondria”

Answer 14

Benda

Question 15

stained mito with Janus B redox dye

Answer 15

Michaelis

Question 16

suggested mito as the site of respiration

Answer 16

Kingsbury

Question 17

confirmed mito as the site of respiration

Answer 17

Kennedy and Lehninger

Question 18

endosymbiotic theory

Answer 18

Sagan

Question 19

genome complexity - euks have very high gene power (resulting in more proteins)

Answer 19

Nick Lane

Question 20

color of blood in artery (bright red) vs vein (dark red), homeostasis

Answer 20

Claude Bernard

Question 21

respiration occurs in the tissues

Answer 21

Pfluger

Question 22

absorption of O2Hb

absorption of deO2Hb

Answer 22

Seyler (O2Hb)

Strokes (deO2Hb)

Question 23

“histohaematin”

Answer 23

MacMunn

Question 24

“radiospectroscope”

Answer 24

Lubbers and Niesel

Question 25

chemiosmosis (ATP synthesis) is a “primary energy conserving event”

Answer 25

Peter Mitchell

Question 26

CytC aa3 reflectance spectrum, NIRs methods

Answer 26

Vandervliet

Question 27

discovery of cytochrome oxidase 
3 cytochromes (a, b, c)

Answer 27

David Kaelin

Question 28

increased O2 = increased glycolysis

action spectra, “atmungsferment”

Answer 28

Otto Warburg

Question 29

5 states of mito respiration

Answer 29

Britton Chance

Question 30

just sufficient O2

Answer 30

LaManna

Question 31

mito defects implicated in lots of diseases (African mtDNA are most diverse)

Answer 31

Douglas Wallace