Histopathology and cytopathology Flashcards

1
Q

What do histopathologists use?

A

Biopsies
Resection specimens- from surgery
Frozen sections- real time diagnosis
Post-mortems

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2
Q

What do cytopathologists use?

A

Smears

Fine needle aspirates

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3
Q

What are the questions that are asked when reviewing histopathology biopsies?

A

Is it normal?
Is it inflamed and if it is, what is the cause?
Is it cancer and if it is, what type is it?

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4
Q

What are the questions that are asked when reviewing resection specimens?

A

How far has the cancer spread?

Is it all out?

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5
Q

How are sections obtained?

A

Specimen must be properly labelled
Fix in formalin
Embed in paraffin wax
Cut sections

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6
Q

What do we do with the sections?

A

Stain e.g. gram, ZN
Identify specific antigens using antibodies = immunohistochemistry
Carry out molecular tests

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7
Q

How long does it take cytopathology and histopathology results to reach the clinician?

A

Cytopathology - pretty fast
Frozen section- 30 minutes
Biopsies- 2-3 days
Resection specimens 5-7 days

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