Histopathology

Question 1

Describe the vascular and cellular responses in acute inflammation.

Answer 1

Vascular responses in an acute inflammation: vasodilation (increased blood vessels), serous, abscess, etc.

Cellular responses in an acute inflammation: increased numbers of immune cells (macrophages, neutrophils (dominant), mast cells, monocytes, plasma cells and fibroblasts.

Question 2

What may be possible outcome of an acute inflammation?

Answer 2

Possible outcomes of an acute inflammation is scaring of the tissue caused by fibroblast-associated repair.

Question 3

What cell types dominate in chronic inflammation?

Answer 3

The cells that dominates an chronic inflammation are the lymphocytes, macrophages, neutrophils

Question 4

Give examples of causes of chronic inflammation.

Answer 4

Persistent viral inflammation, hot/warm cancer, autoimmune diseases, etc.

Question 5

What are giant cells? In what type of inflammation would you expect to find giant cells?

Answer 5

Giant cells consists of multiple macrophages fused together. These are typically found in the chronic inflammatory diseases like Crohn’s disease.

Question 6

What type of lymphocytes dominate in granulomatous infection?

Answer 6

The lymphocyte dominating the granulomatous infections (Crohn’s disease) is T cells.

Question 7

In addition to routine histochemical methods, such as HE staining, we often use immune staining of sections to identify specific cell types. What cells types express CD3, CD20, or CD68, respectively?

Answer 7

CD3 - T cells
CD20 - B cells
CD68 - macrophages