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Histopathology Flashcards

1
Q

Deals with processing and preparation of tissue and cell samples for microscopic examination by the pathologist

A

Histopathology

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2
Q

What profession is responsible in the Histopathology section?

A

Pathologist

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3
Q

Who & what contributed to the history of Histopathology?

A

Johannes Muller
Marcello Malphigi
Rudolf Virchow
Ferdinand Blum
Invention of Microtomes

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4
Q

“Father of Histopathology” / “Father of Histologic Pathology”

A

Johannes Muller

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5
Q

Authored the book “Elements of Physiology” which became the leading textbook in physiology for much of the nineteenth century

A

Johannes Muller

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6
Q

Johannes Muller authored the book ____________ which became the leading textbook in physiology for much of the nineteenth century

A

Elements of Physiology

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7
Q

“Founder of Pathology”/ “Father of Modern Anatomic Pathology”

A

Marcello Malphigi

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8
Q

Became renowned for his exploration of embryology and physiology of the glands and the viscera

A

Marcello Malphigi

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9
Q

Marcello Malphigi became renowned for his exploration of?

A

Embryology and Physiology of the glands and the viscera

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10
Q

Used different methods of fixation, one of which is heat fixation, to preserve tissues and other samples

A

Marcello Malphigi

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11
Q

What fixation did Malphigi utilized to preserve tissue samples

A

Heat fixation

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12
Q

“Founder of Pathology”/ “Father of Modern Anatomic Pathology”

Became renowned for his exploration of embryology and physiology of the glands and the viscera

Used different methods of fixation (discussed below), one of which is heat fixation, to preserve tissues and
other samples

A

Marcello Malphigi

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13
Q

“Father of microscopic pathology”

A

Rudolf Virchow

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14
Q

Credited to have established the world’s first pathology laboratory

A

Rudolf Virchow

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15
Q

Rudolph Virchow is credited to have established the world’s first ______?

A

pathology laboratory

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16
Q

Was the first scientist/ physician of the time who emphasized the study of the manifestation of diseases and infections, which are visible at the cellular level by means of a microscope

A

Rudolf Virchow

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17
Q

“Father of microscopic pathology”

Credited to have established the world’s first pathology laboratory

Was the first scientist/ physician of the time who emphasized the study of the manifestation of diseases and infections, which are visible at the cellular level by means of a microscope

A

Rudolf Virchow

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18
Q

Discovered the fixative effects of formaldehyde

A

Ferdinand Blum

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19
Q

Blum discovered the fixative effects of?

A

Formaldehyde

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20
Q

A machine used for cutting tissue blocks into thin slices called ribbons/ sections

A

Microtome

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21
Q

Microtome is a machine used for cutting tissue blocks into thin slices called

A

ribbons/ sections

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22
Q

4 types of Microtomes

A

Sliding Microtome
Rocking/ Cambridge Microtome
Minot/ Rotary Microtome
Freezing Microtome

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23
Q

Invented by George Adams Jr. in 1798

A

Sliding Microtome

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24
Q

Invented by Paldwell Trefall in 1881

A

Rocking/ Cambridge Microtome

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25
Invented by Minot in 1885-1886
Minot/ Rotary Microtome
26
Invented by Queckett in 1848
Freezing Microtome
27
Routine Process of the Histopathologic Examination
Routine Process: SAMPLE a.) Fixation b.) Dehydration c.) Clearing d.) Infiltration e.) Embedding TISSUE/ CELL BLOCK f.) Trimming g.) Sectioning SECTIONS/ RIBBONS h.) Staining i.) Mounting PREPARED SLIDE FOR MICROSCOPIC EXAMINATION BY PATHOLOGIST
28
What is the 1st process of the sample in routine histopathologic examination?
Fixation
29
What is the 2nd process of the sample in routine histopathologic examination?
Dehydration
30
What is the 3rd process of the sample in routine histopathologic examination?
Clearing
31
What is the 4th process of the sample in routine histopathologic examination?
Infiltration
32
What is the 5th process of the sample in routine histopathologic examination?
Embedding
33
After Embedding what would happen to the sample?
Tissue/ Cell Block
34
What is the 6th process of the tissue/ cell block in routine histopathologic examination?
Trimming
35
What is the 7th process of the tissue/ cell block in routine histopathologic examination?
Sectioning
36
After Sectioning what would happen to the tissue/cell block
Sections/ ribbons
37
What is the 8th process of the section/ ribbon in routine histopathologic examination?
Staining
38
What is the 9th process of the tissue/ cell block in routine histopathologic examination?
Mounting
39
After Mounting what will be done to the sections/ ribbons?
PREPARATION OF SLIDE FOR MICROSCOPIC EXAMINATION BY PATHOLOGIST
40
Preserving the tissue specimen in as life-like a manner as possible
Fixation
41
What is the routine fixative used in the process Fixation?
Routine fixative: 10% formalin
42
Preserving the tissue specimen in as life-like a manner as possible Routine fixative: 10% formalin
Fixation
43
A process of removing water from the specimen
Dehydration
44
In this process it utilizes increasing concentrations of ethyl alcohol
Dehydration
45
Dehydration utilizes increasing concentrations of?
Ethyl alcohol
46
Process of removing water from the specimen Utilizes increasing concentrations of ethyl alcohol
Dehydration
47
A process which removes the dehydrating agents from the sample and replacing it with a fluid miscible with wax
Clearing
48
It is also known as De-alcoholization
Clearing
49
True or False: Clearing produces an opaque appearance of the sample
False Translucent appearance of the sample
50
What is the routine clearing agent in the process of Clearing (De-alcoholization)?
Routine clearing agent: Xylene
51
Removing dehydrating agents from the sample and replacing it with a fluid miscible with wax Produces a translucent appearance of the sample Routine clearing agent: Xylene
Clearing (De-alcoholization)
52
A process where the clearing agent is removed and replaced a fluid that will cover the cavities resulting in a firmer consistency of the sample
Infiltration
53
Also known as Impregnation
Infiltration
54
What is the routine infiltration medium used in the process of Infiltration
Routine infiltration medium: Paraffin
55
Process where the clearing agent is removed Clearing agent is replaced with a fluid that will cover the cavities resulting in a firmer consistency of the sample Routine infiltration medium: Paraffin
Infiltration (Impregnation)
56
The process of arranging the infiltrated tissue inside a mold containing a medium which is then allowed to solidify
Embedding (Casting/ Blocking)
57
What is the routine embedding medium in the process of Embedding?
Routine embedding medium: Paraffin
58
Process of removing excess paraffin wax from the block
Trimming
59
Tissue blocks are cut into thin slices called ribbons/ sections
Sectioning
60
Also known as Microtomy
Sectioning
61
Application of dyes on the sections for studying the architectural pattern of the tissue and physical characteristics of the cell
Staining
62
Process of placing a cover slip on the stained tissue
Mounting
63
Mounting is a process of placing a cover slip on the stained tissue using what type of mounting medium?
Routine mounting medium: Canada Balsam
64
Process of placing a cover slip on the stained tissue using a mounting medium Routine mounting medium: Canada Balsam
Mounting

PMLS FINALS (2 decks)

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