Histology surface epithelium Flashcards
protein of zona occludens that maintains barrier between adjacent cells and apical and lateral domains
Occludin
forms the backbone of each zonula occludens strand
forms the extracellular aqueous channels for paracellular passage of ions
claudins
formation of occluding junctions in endothelial cells betwwen endothelial cells amd monocytes
zipper and seal functions
barrier against paracellular diffusion
Junctional adhesion molecule (JAM)
pathway of substance transport that requires energy
across the plasma membrane of the epithelial cells
Transcellular pathway
across zonula occludens between two adjacent cells
paracellular pathway
The permeabilityy of occluding junction depends on:
molecular composition of aonula occludens strands
number of active aqueous channels
claudins
responsible for the formation of extracellular aqueuous channel
claudins
mechanical stability for epithelial cells
found on lateral cwll surface and basal domain of epithelial cells
structural unity
with signal transduction
cell to cell recognition
interacts with intrmediate filaments
Adhering or anchoring junction, zona adherens
part of every anchoring junction on. oth kayeral and basal cell surfaces
cell adhesion molecules (CAM)
allows cells to easily join and dissociate
selective adhesiveness
linked through a variety of intravellular proteins to components of cell cytoskeleton
cytoplasmic domains
transmembrane Ca+ dependent CAMS
regulate mechanisms of growth snd cell differentiation
Cadherins
interact with extracellular matrix molecules and with actin filaments of cytoskeleton
controls cell movement and shape
integrins
expressed on WBC wnd endothelial cells
mediate neutrophil-endothelial cell recognition
involved in directing lymphocytes
selectins
mediate homotypic cell to cell adhesion
Ig superfamily (IgSF)
for epithelial surface integrity
continuous band belt-like configuration
witn E cadherin
zonula adherens
anchoring crll to cell junction that provides a strong attchement
macula adherens (desmosome)
cytoplasmic bundles containing bundle
cillia
inter al structure found in the hair.ike extensionsof the apical plasma membrane
axoneme microtubule based
where axoneme. extends from centriole-derived microtubule
basal body
what are the classification of cillia?
motile
primary
nodal
numerous on the apical domain of many epithelial cells
with flagella to transports
erm
has 9+2 axonemal organization
motile cillia
solitary prijections found on eukaryotic cells
monocilia-single cilium per cell
immotile
chemosensors, light sensors, sound perception
primary ciliia (monocilia)
found in bilaminarembryonicdisc of the embryo(gastrulation)
surroundsprimitive node
performs rotational movement
for early embryonic development
nodal cillia
short, fine, hair-like structures
motil cilia
thin darkstaining band extending across the cell at the base of the cilia
basal bodies
from the tip of the cilium to its base
9+2 microtubule array