Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Renal SCE > Histology > Flashcards

Histology Flashcards

1
Q

Causes of Granular IgG on IF

A

Primary membranous, SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Causes of Linear IgG on IIF

A

Anti GBM disease, diabetes, monoclonal immunoglobulin deposition disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Causes of mesangial IgG staining

A

Lupus, IgA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Features of membranous Nephropathy

A

Thickened BM, Spikes on silver stain, subepithelial deposits
IgG4 subclasses

Note - mesangial deposits more likely in secondary MN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Features of FSGS

A

> 70% foot process effacement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Causes of subendothelial deposits

A

Lupus (class3-4), MPGN, cryoglobulinaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Causes of intramembranous deposits

A

Dense deposit disease, C3 factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Features of transplant glomerulopathy

A

Double contouring on silver stain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Features of Amyloid

A

Congo red, apple bifringe, PAS negative - look pale

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Features associated with IgA

A

KM55 - positive on renal Bx
Glomerulosclerosis
Tubulointerstitial fibrosis
Mesangial hypercellularity
Endocapillary hypercellularity
Crescents

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Features of post infection GN on renal Bx

A

Diffuse proliferative GN
Hypercellularity - monocytes and neutrophils
IIF - dominant C3 staining. some IgG
Starry sky pattern
Irregular mesangial and capillary wall pattern
SubEpitheilial humps / deposits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

C3 Glomeulonephritis

A

C3 deposits in the mesangium and subendothelial space

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Name 5 Lupus classes on histology

A

The standard classification divides these into five different patterns:

I - No disease
II - Mesangial proliferation
III - Focal proliferative
IV - Diffuse proliferative
V - Membranous.
VI = Sclerosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Histological features of Membranoproliferative glomerulonephritis aka Mesangiocapillary GN

A

Double contour / splitting of GBM = Tram Tracks
mesangial and endothelial cell proliferation,
expansion of the mesangial matrix
thickening of the peripheral capillary walls.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Features seen with BK infection

A

Cd4 positive staining
SV -40 antigen seen in tubular epithelial cells.
Inclusion bodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Features of Lupus

A

Proliferation of capillaries and obliteration of capillary loops - capillaries stain deep red =”wire loop” lesion
Full house immunology
increase in mesangial matrix volume
Subendothelial deposits
Mesangial fingerprinting

17
Q

Features of Alports on renal Bx

A

Loss of podocytes
Thin GBM - look’s like ‘basket weave’
Splitting of lamina densa
Looks similar to FSGS

18
Q

When do you see Kimmelstiel-Wilson lesions

A

Depict nodular glomerulosclerosis
Seen in diabetic related kidney disease.

19
Q

When do you see inclusion body’s versus owls eyes

A

Owl’s eyes = CMV
Inclusion bodys = BK (seen with SV 40)

20
Q

Features of Oxalate nephropathy on renal Bx

A

Calcium oxalate deposition within the tubular epithelial cells and lumen
Crystals appear translucent
Look like ‘fan-like’ / sheaf like / sunburst
Strongly birefringent under polarized light

21
Q

Features of glomerular nephropathy as they occur

A

1) Tubular cell hypertrophy - causes hyperfiltration
2) Thickening of GBM
3) Thickening of tubular membrane
4) Kimmelsteil- wilson nodules
5) Glomerular microaneurysums

22
Q

When do you see tubular reticulocyte inclusion bodies

A

SLE
HIV
interferon

23
Q

Difference between hyaline casts and fractured casts

A

fractured casts - cells around the edge due to it being an inflammatory process. Hyaline cells - no cells around the edge

24
Q

Differentials for increased inflammatory cells in transplant Bx

A

Tcell mediated rejection / cellular rejection
Viruses - BK

25
Q

Features on Bx in Light chain cast nephropathy

A

Aka myeloma cast nephropathy

Kappa on IF
Fractured casts

26
Q

Features of dense deposit disease

A

Intramembranous, sausage like deposits
Common cause is C3 nephritic factor- antibody which inhibits Factor H, allowing uncontrolled activation of the alternative pathway of complement. Causes very low levels of serum C3.

27
Q

Causes of cresents on renal Bx

A

ANCA
IgA /HSP
Lupus
Anti GBM
Post infectious GN

28
Q

Features of IgG4 on renal biopsy

A

IgG4 positive Plasma cell
lymphocytic infiltration in the tubulointerstitial compartment
Storiform fibrosis

29
Q

Features of Class 2-3-4-5 lupus

A

Class 2 = Mesangial proliferation
Class 3 = <50% gloms affected
Class 4 = >50% gloms affected
Class 5 = Subepithelial deposits

30
Q

Features of acute tubular necrosis on renal Bx

A

Flattening of tubular cells
Intratubular cast formation
History of muddy brown / granular casts

Renal SCE (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions