Histo/Path of Cartilage

Question 1

3 types of cartilage

Answer 1

Hyaline
Elastic
Fibrocartilage

Question 2

Perichondrium

Answer 2

Outer fibrous CT sheath
Contains vascular supply for avascular cartialge
Inner chondrogenic layer is essential for growth and maintenance
Absent on articular cartilage and fibrocartilage

Question 3

What type of collagen is in

1. Hyaline
2. Fibrocartilage

Answer 3

1. Type 2

2. Type 1

Question 4

Arthropathy

Answer 4

General term for any disease of joint

Ex: arthritis, trauma, etc

Question 5

OA definition

Answer 5

Chronic progressive disease of joints characterized by degeneration of articular cartilage resulting in structural and functional changes
Few inflammatory cells identified
Inflammatory mediators are involved

Question 6

Early changes of OA

Answer 6

Chondrocytes proliferate, release inflammatory mediators
Remodelling of cartilage matrix
Secondary changes in synovium and subchondral bone (fissuring and clefting)

Question 7

Late changes of OA

Answer 7

Loss of chondrocytes
Loss of cartilage
Subchondral changes (eburnation)
Sclerosis of underlying cancellous bone
Subchondral bone cysts
Osteophytes

Question 8

Clinical features of OA

Answer 8

Stiff, tender, and painful joints
Typically increases with use
Usually oligoarticular
No extra articular features

Question 9

3 types of symptomatic relief

Answer 9

Pain relief (NSAIDs, injections)
Modify activities
Arthroplasty