Histo - code

Question 1

Which 2 proteins in the epithelium does CHOLERA toxin act on?

Answer 1

ZO-1 & ZO-2

Both help maintain tight junctions

Question 2

What 3 proteins seal tight junctions in epithelium?

Answer 2

JAM, Claudin, occludin

Question 3

Clostridium bacteria destroys what protein in tight junctions, causing increased fluid flow and diarrhea?

Answer 3

Claudin

Question 4

The basal lamina is composed of 6 things:

Answer 4

Lamina & collagen 4 (ep)

Fibronectin (fibroblasts)

Heparan sulfate proteogylcan (perlecan)

Nidogen/entactin (glycoproteins)

Question 5

What layer of skin are Merkel cells found?

Answer 5

Stratum basale

Question 6

What layer of skin are langerhans cells found in?

Answer 6

Stratum spinosum

Question 7

What layer are melanocytes found in?

Answer 7

Stratum basale

Question 8

What is the enzyme that creates melanin, and from what does melanin derive from?

Answer 8

Tyrosine + tyrosinase -> DOPA -> melanin

Question 9

Epidermolysis bullosa simplex is a disorder caused by a mutation where?

Answer 9

Intermediate filaments of hemidesmosomes

Question 10

Junctional epidermolysis bullosa is caused by a mutation where?

Answer 10

Type 17 collagen - attaches cell membrane to basal lamina

Question 11

Dystrophic epidermolysis bullosa is caused by a mutation where?

Answer 11

Type 7 collagen - anchors fibril loops

Question 12

What lethal autoimmune disease affects the desmosome protein desmoglein, causing blistering?

Answer 12

Pemphigus vulgaris