Higher Brain Functions Flashcards
Describe the theory of localization of higher brain centers?
Theory that specific areas of the brain are associated with particular physical and physiological functions
1. Motor cortex -
2. somatosensory cortex - auditory
3. visual cortex -
4. auditory cortex -
5. Broca’s area - word formation
6. Wernicke’s area - language comprehension intelligence
Describe the hemispheric lateralization of the left hemisphere?
LEFT hemisphere - VALL (Language)
- Verbal aspects of consciousness
- Analytical reasoning
- Logic
- Linguistic Skills
Describe the hemispheric lateralization of the right hemisphere?
RIGHT hemisphere - SHAME (Spatial)
- Spatial
- Holistic
- Artistic
- Musical
- Emotional
What 3 components of the nervous system influence behavior?
- The secretory hypothalamus
- The autonomic nervous system
- Diffuse modulatory systems
What is the function of the secretory hypothalamus?
Regulates homeostasis by controlling hormonal release of the pituitary gland
What are the 3 functional zones of the hypothalamus?
Lateral
Medial
Periventricular
Describe the cells in the periventricular zone of the hypothalamus?
- suprachiasmatic nucleus (circadian rhythm)
- cells that control the ANS and regulate the outflow of the autonomic innervation of the visceral organs
- neurosecretory neurons that extend axons down toward the stalk of the pituitary gland
Describe the function of the magnocellular neurosecretory cells of the hypothalamus?
• Magnocellular neurosecretory cells release two neurohormones into the bloodstream :
1. Oxytocin: levels rise during sexual or intimate behaviors, promotes social bonding, stimulates uterine contractions, milk ejection
2. Vasopressin/antidiuretic hormone (ADH): regulates blood volume and salt concentration
Describe the function of the parvocellular neurosecretory of the hypothalamus?
• Parvocellular neurosecretory cells control the anterior pituitary
- Their axons do not extend all the way into the anterior lobe so they secrete
hypophysiotropic hormones into the hypothalamo-pituitary portal circulation
> The hormones bind to specific receptors, causing pituitary cells to either secrete or stop secreting hormones
E.g. follicle-stimulating hormone, luteinizing hormone, thyroid-stimulating hormone, adrenocorticotropic hormone/corticotropin, growth hormone, prolactin
What are the typical principles of diffuse modulators systems?
- Typically, the core of each system has a small set of neurons (several thousand).
- Neurons of the diffuse systems arise from the central core of the brain, most of them from the brain stem.
- Each neuron can influence many others because each one has an axon that may contact more than 100,000 postsynaptic neurons spread widely across the brain.
- The synapses made by many of these systems release transmitter molecules into the extracellular fluid, so they can diffuse to many neurons rather than be confined to the vicinity of the synaptic cleft.
Describe the noradrenergic diffuse modulatory system?
• arises from the locus coeruleus
• Besides being a neurotransmitter in the peripheral ANS, NE is also used by neurons of the tiny locus coeruleus in the pons
• Locus coeruleus cells are involved in the regulation of attention, arousal, and sleep-wake cycles, learning and memory, anxiety and pain, mood, and brain metabolism
- cells fire most rapidly during wakefulness and are most quiet during sleep
Describe the serotonergic diffuse modulators system?
•arise from raphe
• Serotonin-containing neurons are mostly clustered within the nine raphe nuclei
• Each nucleus projects to different regions of the CNS
- Those more caudal, in the medulla, innervate the spinal cord, where they modulate pain-related sensory signals
- Those more rostral, in the pons and midbrain, innervate most of the brain in much the same diffuse way as do the locus coeruleus neurons
• Similar to neurons of the locus coeruleus, raphe nuclei cells fire most rapidly during wakefulness and are most quiet during sleep
Describe the dopaminergic diffuse modulatory system?
•arises from the substantia nigra and the ventral regimental area
• The dopaminergic projection from the midbrain innervates the limbic system which is involved in reward and motivation behaviour
Describe the cholinergic diffuse modulatory system?
• arises from the basal forebrain and brain stem
1. Medial septal nuclei: provide the cholinergic innervation of the hippocampus,
2. Basal nucleus of Mevnert:
provides most of the cholinergic innervation of the neocortex
• Activation of these acetylcholine neurons leads to an acutely awake and excited nervous system.
What is the function of the limbic system?
Responsible for those special types of behavior associated with emotion, learning and memory
What is the central element of the limbic system from a physiological point of view?
Hypothalamus