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Heme And Lymph > High Yield Genetic Markers > Flashcards

High Yield Genetic Markers Flashcards

1
Q

T-ALL

A

NOTCH 1

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2
Q

Both B-ALL and T-ALL

A

Tdt - terminal deoxynuckeotidyl transferase

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3
Q

Markers found in B-ALL

A

CD19, PAX5, CD10

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4
Q

Translocations associated with ALL:

A

T(12;21) - GOOD

T(9;22) - BAD

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5
Q

Surface markers for CLL/SLL?

A

CD 23 and CD 5

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6
Q

Worse prognosis for CLL is associated with these genes:

A

ZAP70 and NOTCH 1

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7
Q

Translocation that causes follicular lymphoma?

A

T(14;18)
Also see BCL2
CD5-

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8
Q

DLBCL genetics?

A

BCL6, possibly BCL2 if it transformed from follicular

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9
Q

Genetic markers in Burkitt lymphoma?

A

c-MYC +

BCL2 -

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10
Q

Plasma cells in multiple myeloma are positive for?

A

CD138 and CD56

Translocations with cyclin D1 = GOOD
Deletions = BAD

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11
Q

Gene associated with lymphoplasmacytic lymphoma?

A

MYD88

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12
Q

Translocation in mantle cell lymphoma?

A

T(11;14) - cyclin D1

CD5+, CD23-

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13
Q

Genetic mutations in hairy cell leukemia?

A

BRAF

CD11c, CD25, CD103, and annexin A

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14
Q

Which disease is associated with mycobacterial infections?

A

Hairy cell leukemia

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15
Q

Which disease is associated with ALK+, CD30+?

A

Anaplastic large cell lymphoma

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16
Q

Which disease is associated with HTLV1?

A

Adult T cell leukemia (tropical spastic paraparesis)

17
Q

Which disease is associated with CLA, CCR4, and CCR10?

A

Mycosis fungoides

CLA = cutaneous leukocyte antigen

18
Q

What are the cell surface markers for large granular lymphocytic leukemia?

A

T cell type: CD3+
NK cell type: CD3-, CD56+

Both will have mutations in STAT3

19
Q

Which virus is associated with extranodal NK/T cell lymphoma?

A

EBV

These are CD3-, CD21- though

20
Q

What are the markers for the classic types of Hodgkin?

A

PAX5, CD15, and CD30

21
Q

Cell surface markers for uncommon type of Hodgkin?

A

CD19 and CD20 +

CD15 and CD30 -

22
Q

AML translocation with the best prognosis?

A

T(15;17)

23
Q

AMLs with good prognosis translocations?

A

T(8;21) and INV(16)

24
Q

Chromosomal abnormalities in MDS?

A

Monosomy of 5 or 7
Deletions
Trisomy 8 (involves cMYC)

25
Q

Genetic mutation in CML?

A

T(9;22) - Philadelphia chromosome

BCR-ABL fusion gene

26
Q

Genetic mutation in PV?

A

JAK2 point mutation

27
Q

Genetic mutations in ET and PM?

A

JAK2 or MPL point mutation

28
Q

Genetic mutation in systemic mastocytosis?

A

KIT point mutation

29
Q

Cell surface markers in Langerhans Histiocytosis?

A

S-100, CD1a, CCR7

Plus a mutation in BRAF

Heme And Lymph (3 decks)

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