High Yield Genetic Markers

Question 1

T-ALL

Answer 1

NOTCH 1

Question 2

Both B-ALL and T-ALL

Answer 2

Tdt - terminal deoxynuckeotidyl transferase

Question 3

Markers found in B-ALL

Answer 3

CD19, PAX5, CD10

Question 4

Translocations associated with ALL:

Answer 4

T(12;21) - GOOD

T(9;22) - BAD

Question 5

Surface markers for CLL/SLL?

Answer 5

CD 23 and CD 5

Question 6

Worse prognosis for CLL is associated with these genes:

Answer 6

ZAP70 and NOTCH 1

Question 7

Translocation that causes follicular lymphoma?

Answer 7

T(14;18)
Also see BCL2
CD5-

Question 8

DLBCL genetics?

Answer 8

BCL6, possibly BCL2 if it transformed from follicular

Question 9

Genetic markers in Burkitt lymphoma?

Answer 9

c-MYC +

BCL2 -

Question 10

Plasma cells in multiple myeloma are positive for?

Answer 10

CD138 and CD56

Translocations with cyclin D1 = GOOD
Deletions = BAD

Question 11

Gene associated with lymphoplasmacytic lymphoma?

Answer 11

MYD88

Question 12

Translocation in mantle cell lymphoma?

Answer 12

T(11;14) - cyclin D1

CD5+, CD23-

Question 13

Genetic mutations in hairy cell leukemia?

Answer 13

BRAF

CD11c, CD25, CD103, and annexin A

Question 14

Which disease is associated with mycobacterial infections?

Answer 14

Hairy cell leukemia

Question 15

Which disease is associated with ALK+, CD30+?

Answer 15

Anaplastic large cell lymphoma

Question 16

Which disease is associated with HTLV1?

Answer 16

Adult T cell leukemia (tropical spastic paraparesis)

Question 17

Which disease is associated with CLA, CCR4, and CCR10?

Answer 17

Mycosis fungoides

CLA = cutaneous leukocyte antigen

Question 18

What are the cell surface markers for large granular lymphocytic leukemia?

Answer 18

T cell type: CD3+
NK cell type: CD3-, CD56+

Both will have mutations in STAT3

Question 19

Which virus is associated with extranodal NK/T cell lymphoma?

Answer 19

EBV

These are CD3-, CD21- though

Question 20

What are the markers for the classic types of Hodgkin?

Answer 20

PAX5, CD15, and CD30

Question 21

Cell surface markers for uncommon type of Hodgkin?

Answer 21

CD19 and CD20 +

CD15 and CD30 -

Question 22

AML translocation with the best prognosis?

Answer 22

T(15;17)

Question 23

AMLs with good prognosis translocations?

Answer 23

T(8;21) and INV(16)

Question 24

Chromosomal abnormalities in MDS?

Answer 24

Monosomy of 5 or 7
Deletions
Trisomy 8 (involves cMYC)

Question 25

Genetic mutation in CML?

Answer 25

T(9;22) - Philadelphia chromosome | BCR-ABL fusion gene

Question 26

Genetic mutation in PV?

Answer 26

JAK2 point mutation

Question 27

Genetic mutations in ET and PM?

Answer 27

JAK2 or MPL point mutation

Question 28

Genetic mutation in systemic mastocytosis?

Answer 28

KIT point mutation

Question 29

Cell surface markers in Langerhans Histiocytosis?

Answer 29

S-100, CD1a, CCR7 | Plus a mutation in BRAF