High Yield Facts Flashcards
Chest xray of pt who is Alcoholic with fever, chills, and obvious signs of pleural issue within the lung cavity. What microbe is suspected?
Klebsiella pneumonia
HIV Markers correlate with:
p24
gp120
gp41
P34= Old HIV infection
GP120/GP41 help bind and fuse the virus inside the cell
Tx for C.trachomatis
MOA of Tx
Azithromycin
or
Doxycycline
African American taking Primaquine and has dark urine. What blood disorder ?
G6PD Deficiency
Sudden death, thick myocardium, and decreased diastolic function
Hypertrophic Cardiomyopathy (HCM)
History of anemia, scleral icterus, hepatoslenomegaly, Hb=9 and Hct=33%, unconjugated bilirubin with peripheral smear of LARGE ROUND ERYTHROCYTES w/o Central Pallor?
Hereditary Spherocytosis
History of gastritis, anemia, and atrophic glossitis. Low B12. What results due to pernicious anemia?
Loss of Intrinsic Factor
Patient has rhonchi that indicates aspiration of food. Vomits all meals since birth in a 3 day old child
Tracheoesophageal fistula
What change in sleep electrical activities is seen in depressed patients?
Decreased delta sleep waves
Most specific testing for HIV
Western blot (PROTEIN)
Mechanism of Cyanide poisoning
Cyanide binds to iron of cytochrome oxidase
Tx for friends and close contacts of a patient with N.meningitis
MOA of Tx
Rifampin
MOA:
Serum Iron 500
Ferritin 10
TIBC 500 (elevated)
Low Hb
Anemia of Iron Deficiency
Rheumatoid Arthritis feature
Synovitis
Osteoarthritis Features
Heberden nodes
Osteophytes
Bone eburnation
Subchondral Bone formation
3yr old Immigrant w/ sever cough described as short coughs with copious mucous followed by a peculiar grunt. What is the illness?
Bordetella Pertussis aka Whooping Cough
Anaphylaxis Drug allergy occurs via
Good Pasture pathophysiology and HSR?
Rheumatoid arthritis HSR?
Type 1 HSR = IgE Crosslinking
Good Pasture = Type II HSR
Rheumatoid arthritis = Type III HSR = immune complex
Alcoholic patient with liver disease and hyperlipidemia.
What drug is contraindicated and why?
What is an alternative drug that can be given?
ATORVASTATIN aka Lipitor
Inhibits HMG-Coa Reductase and damages liver and muscle cells.
Alternative: Gemfibrozil
Fever, yellow sputum w/ blood and large cavity lesion in upper right lobe of lung
Granulomatous lesion with acid fast bacilli (TB). Cavitation description always refers to TB
Young AA female with SOB, diffuse lymphadenopathy, subcutaneous nodules, fine dry crackles on lung auscultation. Hilar Lymphadenopathy
Disease?
What will be elevated in disease process?
Sarcoidosis
ACE and Alpha1Hydroxylase enzyme levels will be elevated
Bloody diarrhea, continuous inflammation from rectum. Inflammation involves mucosa w/o involving entire thickness
Disease?
Ulcerative Colitis involves the mucosa and submucosa inflammation
Succinylcholine will have a prolonged effect due to what enzyme deficiency?
Deficiency of Pseudocholinesterase
Median nerve w/ carpal tunnel will cause pain in which part of the hand?
Radial half of the palm
ST segment elevations in Leads V3-V4 are due to what?
LAD occlusion. Most common location for MI
Iron is maintained in a reduced state by what?
NADPH
What cells lack mitochondria?
Red Blood Cells
Anti-dsDNA Antibody is related to what disease?
SLE
Anti-centromere antibody is related to what disease?
CREST Syndrome
Relative refractory period of cardiac potential in Purkinje fibers is what phase?
Phase 3 which is efflux of K+
Primary Biliary Cirrhosis is associated with what autoimmune antibody?
Anti-mitochondrial antibodies
Systemic emboli cause what?
Paradoxical embolism
Hb curve LEFT shift occurs from what?
Carbon monoxide (HbCO)
Decreased 2,3 BPG
Cold
Where is the Posterior Descending artery (PDA) located?
Distal to the Left subclavian a.
Hallucinations right before waking up is known as?
Hallucinations upon falling asleep is known as?
Hypnopompic
Hypnagogic
What cell type is dependent exclusively on glucose for fuel?
RBC
Hepatic dysfunction patients should be on what restriction diet?
HTN patients should be on what diet?
LOW PROTEIN for patients with liver issues
HTN patients should Restrict Salt (Na+)
What is the MOA for Fondaparinux?
Inhibits the formation of Factor Xa
Why does it take time for Warfarin’s to be effective?
Clotting factor degradation rates take time
Renal failure that is reversible is called?
What is a significant finding for it?
Acute Tubular Necrosis (ATN)
Muddy brown casts in the urine (Acute renal failure)
Thrombocytic thrombocytopenic purpura (TTP)
Features?
Peripheral blood smear?
What should not be given to these patients?
Fever, neurological deficits, purpura, hemolysis, anemia
Schistocytes
They SHOULD NOT BE GIVEN PLATELETS since they could thrombose again.
Infant with cataracts, deafness, pulmonic stenosis, microcephaly, blue lesions on the body. What is the causal agent?
Rubella Virus
Triad: Microcephaly, Cataracts, Deafness
Pregnant women with tingling in hands. What structure contributes to the tingling?
Flexor Retinaculum
Young child w/ fatigue, exercise intolerance after play, cyanosis, and systolic ejection fraction murmur at LSB
What is the disease?
What would a catheter in the RV show?
Tetralogy of Fallot: VSD, Pulmonary stenosis, RV hypertrophy, and Cyanosis
Increased BP
Person exposed to second hand smoke for life, Xray with peripheral opacity. What disease?
Bronchoalveolar Adenocarcinoma..always occurs peripherally in lung
40yr old male, vague abdominal pain, weight loss, diarrhea.
What is the disease?
What is seen upon closer exam?
Crohn’s Disease
Will show sarcoid like “NONCASEATING TRANSMURAL EPITHELIOID GRANULOMAS” in the intestinal wall
Acetaminophen toxicity results in what?
Centrilobular necrosis of the liver
Most specific test for diagnosis of SLE
Anti-ds DNA antibodies
Rheumatic valve disease patient will have what kind of murmur?
Describe the murmur
Mitral Stenosis: snapping early diastolic click and mid diastolic rumble. Also described as a low pitched diastolic rumble preceded by opening snap
SNAP= Stenosis
Scar tissue in the brain is created by what?
Astrocytes
What are the macrophages of the CNS system?
Microglia
What muscle helps to initiate ABduction of the shoulder?
What innervates it?
Supraspinatus innervated by…
25 yo woman experiences transient cerebral ischemia. She’s found to have upper limb BP asymmetry. What is the disease?
Takayasu Disease: large vasculitis in young women that commonly affects the aorta aka “Pulseless disease”
25 yo woman with nontender erythematous rash over her nose, cheeks, and polyarthritis. What will lab tests show?
Anti-Smith or Anti-ds DNA antibodies for SLE
Hepatic conjugation involves?
Glucoronide formation
Potency of gas depends on?
Oil/Gas partition coefficient and membrane solubility
Phase 1 of acute inflammation–Vasodilation and increased blood flow are caused by?
Bradykinin
Most common place for obstruction hydrocephalous after traumatic injury is?
Cerebral Aqueduct of Sylvius
Narrowed mainstem bronchus by 50% will lead to what change in airway resistance?
Greater than 100%
Conductance is proportional to the diameter to the fourth power, narrowing of lumen by 50% would increase airway resistance 16 fold
Child with calcified mass in the suprasella region and peripheral blindness
Disease?
Craniopharyngioma (supratentorial mass)
What common causes Nasopharyngeal Carcinoma?
Ebstein Barr virus (EBV)
Common drug addiction
Oxycodone
Tick bite 10 days ago, fever, headache, peripheral rash that spreads to involve the trunk and face. Petechiae present from BP cuff.
Disease?
Cause?
Rickettsia rickettsii caused by tick
AA female around 35yo with fever, weight loss, arthralgia, Lymphadenopahy and hypergammaglobulinemia, hyperuricemia and restrictive pattern of lung disease.
Disease?
Chest Xray will reveal what?
Sarcoidosis. Will show hilar adenopathy on xray
Small population in a study, the significance of the results will be most limited what what?
Type II Error
Adequate sample size protects against this error, which is beta or false negative, the incorrect acceptance of the null hypothesis.
Type I Error would be thinking the results are true when they are false.
Elderly hospitalized with nosocomial pneumonia (upper lobar) with organism that has “mucoid agar growth”
Klebsiella pneumonia
Absolute risk = 1/100,000 but health car workers contract it 50x the rate of general population. What is the number of healthcare workers who require immunization to prevent one additional case?
2000
Since healthcare workers have 50x risk then their rate of infection is 50/100,000 = 1/2,000. The NNT is the inverse of the absolute risk ratio (1/2000)
19yr old woman with multiple erythematous lesions with silvery scales, pitting lesions in the nails. Lab test with HLA-B27.
Disease?
Psoriatic arthritis
Enzyme in Kreb cycle found in the inner mitochondrial membrane?
Succinate Dehydrogenase
60yo alchoholic in early stages of recovery. What agent will block cravings?
Naltrexone
What is the rescue drug to help with opioid overdose?
Naloxone
Pt with hypertrophic cardiomyopathy and primary AV block should be treated by?
What’s the drug MOA?
Verapamil (Non-DHP)
MOA:
Slow acetylators are at increased risk for drug induced lupus by what drug?
What’s the drug MOA?
Procainamide
MOA:
Psychiatric patient recently put on medication and develops increased urinary output. What are they taking?
Lithum sulfate…blocks the effects of ADH and likes to cause Nephrogenic DI
What are the features of Nodular Hyaline Glomerulosclerosis?
Diabetes affect the kidney and leads to Mesangial deposits and KM granules
Young boy with history of joint pains. Tea colored urine. Weakness in arms and legs without obvious deformity. Cartilaginous pigmentation of pinnae. Degenerative arthritic changes in long bones?
Diagnosis?
Deficiency?
Alkaptonuria due to deficiency homogentisic oxidase
Will lead to accumulation of homogentisic acid in joints, dark/black urine and pigmented cartilage.
40yr old man with new onset dyspnea, tachypnea, headache, confusion. Has cherry red color of skin and mucous membranes. Toxin is lethal via effects on Hb and by?
Carbon Monoxide poisoning leads to Inhibition of the activity of cytochrome oxidase
70 yr old man with pancreatic cancer, new onset dizziness, cold extremities, chest pain. Blowing systolic murmur heard best at the apex. Echo shows SMALL FIBRIN DEPOSITS randomly on the MITRAL AND AORTIC VALVES.
Disease?
Nonbacterial Thrombotic Endocarditis
Deep knife wound to the leg. Site of entry is purplish and very tender. Evidence of gas production by surrounding tissue. What microbe is responsible?
Clostridium Perfringens causes skin necrosis with black debris and gas
Fever, Night sweat, weight loss, cervical lymphadenopathy. Lymph node has large reticulum cell multinucleated, bi- and tri-lobed masses.
Disease?
Hodgkin’s Disease with REED STERNBERG cells (large cells with bi- or trilobed nuclei) present
Most important excretory product of protein/nitrogen metabolism is?
Urea
Child below 5th percentile for height/weight but in 95th for head circumference. Teeth are carious and xray show bone demineralization.
Disease?
SEs of therapy for this condition include?
Rickets
Treatment may cause Hypercalcemia
What is the cellular marker for Reed Sternberg cells
CD30+
Pt has seizure in ER. BITTER ALMOND BREATH Trismus and must be mechanically ventilated and expires. MOA of toxic effect of the cellular hypoxia produced by the formation of the inactive complex of cyanide and XX?
Complex IV (Cytochrome oxidase) = Cyanide
Massive splenomegaly, Low Hb, Low Hct, Elevated WBC count, and low leukocyte alkaline phosphatase
Chronic Myelogenous Leukemia (CML)
The low leukocyte alkaline phosphatase and the WBC>100k are giveaways
What drug improves efficiency of the heart, typically given to patients with previous history of heart failure?
IV DIGOXIN
CHF can shift the starling curve left via a positive iotrope
55yo, not married, lives alone, and forms no normal social relationship. Has magical thoughts. Alone and strange thoughts
SCHITZOTYPICAL
Combination of impaired social interaction and odd thinking, behavior, and speech.
Inability to name object with vision alone without aid of touch
Visual Agnosia
Oxidative phosphorylation happens where?
Inner Mitochondrial membrane
Necrosis of renal papillae in women with proteinuria
Diabetes Mellitus commonly associated with renal papillary necrosis
Pts that take Phenothiazine are at risk for developing what?
Masked facies and altered gait. Extrapyramidal SEs similar to parkinsons since dopaminergic.
Ebstein’s anomaly associated with maternal-fetal exposure to lithium carbonate, the anomaly includes?
Ventricular displacement of the Tricuspid valve
Hexose monophosphate shunt is regulated by?
Ratio of NADPH/NADH ratio
Contaminated water disease causes pulmonary HTN w/ Cor pulmonale heart disease. A variant form of the ivader is commonly seen in Egypt where it is linked to causing SCC of the bladder.
Disease?
Schistoscomiasis due to Schistosoma haematobium that leads to SCC of the bladder
Fast knee reflex is mediated by what tract?
Vestibulospinal
What is the electrolyte content of the bronchial mucus in a CF patient?
Low Chloride
High Elastase
Sweat had elevated chloride
MAO inhibitors + Patient having wine/cheese can lead to bad rxn. What drugs would be an issue?
Tranylcypromine sulfate (Phenelzine, Isocarboxazid)
Diet of mainly corn, pruritic skin rash, diarrhea, red tongue, altered mental status
Deficiency of Vit B3 (NIACIN) = Pellagra
50yo with deterioration of cognitive function via a prion
Subacute Spongiform Ecephalopathy
Melanin pigmentation of oral mucosa, lips, hands, scrotum, and complaints of hematochezia. What would you expect to find upon colonoscopy?
Disease?
Peutz Jegher Syndrome
Will see HAMARTOMAS on colonoscopy.
Irregular spasmodic movements of face and arms and loss of recent memories and impaired judgment
Changes in Caudate nucleus due to DECREASED GABA
4yr old with Lymphoblasts on peripheral blood sample
Translocation?
Acute Lymphocytic (Lymphoblastic) Leukemia
t(12;21)
32 yr old women during second trimester have heat intolerance, nervous, tremor, increased resting HR, proptosis. What would be found on histological section?
Diffuse Thyroid Hyperplasia with follicular hypercellularity and colloidal shrinkage aka GRAVES DISEASE (common in pregnancy)
Fatigue, weakness, balance difficulties, with positive Romberg sign and Macrocytic anemia.
What’s the vitamin deficiency?
What test would identity the deficiency?
Vitamin B12
Schilling’s Test: measures Vit B12 absorption w/ and w/o IF
How can you identify manic type of patients?
Mood disturbance, Hyperactivity, GRANDIOSITY, decreased need for sleep, RACING THOUGHTS, PRESSURED SPEECH, and involvement in dangerous activities.
Berylliosis mimics sarcoidosis in xrays. What industry do workers commonly obtain this disorder?
METAL PLANTs providing beryllium products to the AEROSPACE PROGRAM
Leads to restrictive lung disease
Irritable Bowel Syndrome associated with what?
Associated with PRETIBIAL ERYTHEMA NODOSUM and pyoderma gangrenosum lesion over ankle and uveitis
4yr old with Lymphopenia, failure to thrive, recurrent infections with normal and opportunistic agents. Hyperuricemia
Deficiency of Adenosine Deaminase
Eaton Lambert Syndrome of impaired ACh release is associated with men who have?
Oat Cell Carcinoma of the lung aka small cell
Crystal violet by gram positive is due to?
Peptidoglycan layer
What is the primary lipid storage product in adipose?
Triacylglycerol
Rheumatic disease in 40yo with myalgias, weight loss, fatigue, what else will the patient most likely have?
POLYARTERITIS NODOSA is common in patients with rheumatoid arthritis
Prader Willi occurs how?
Differential methylation of genetic material dependent on parental source of inheritance
“Doctor, you are beginning to sound just like my mother” What is this an example of?
Transference
Chronic Alcoholic with WIDE BASED GAIT due to permanent damage to what structure?
Cerebellar Vermis
What characterizes Francisella Tularensis?
Gram negative zoonotic bacilus
Female with mosaicism variant of Down Syndrome
46XX, 47XX +21
What cell produces of beta-hCG?
Syncytiotrophoblast
“Reduce sentence each time inmate is cooperative” is an example of what?
Negative Reinforcement. Rewarding by removing a negative
Most common cause of Subarachnoid hemorrhage with the worst headache of their life?
What is it associated with?
Defect in ANTERIOR COMMUNICATING ARTERY (Berry Aneurysm)
Is associated with adult kidney disease
Sensory stimulus to contract and respond by relaxation when tension is too high as a way to protect the muscle
Golgi Tendon organ
Child with distended abdomen with mother w/ decreased amniotic fluid (Oligohydramnios), what is the most likely cause
Urethral valve obstruction
Livestock farmer with goats and cattle, 1 year long fever. What would you expect upon biopsy of the patient’s bone marrow?
Cause of the illness?
Granuloma from infection with BRUCELLA species with an undulant fever that can last years
Hyperthyroidism. What would be used to control arrhythmias?
Propanolol
Multiple myeloma monoclonal antibody
IgG spike
What is Bombesin?
Secretagogue on pancreatic acinar cells
Amphotericin B MOA to fight Candida infection?
Disruption of ergosterol containing membranes
What drug inhibits 5-lipooxygenase?
Zileuton
What drug can cause Asthma?
Aspirin
8yr old with ALL develops bilateral interstitial pulmonary infiltrates, diagnostic lung biopsy is performed and shows spherical structures within the alveoli of the lung impregnated with silver stain.
Cysts from Pneumocystis Carinii. (Any lung biopsy that reveals things with silver stain is automatically pneumo carinii)
Adrenal cortex cells that synthesize mineralcorticoids have an abundance of what structure?
SMOOTH ER which is the site of synthesis of steroids like mineralcorticoids, glucocorticoids, andrograns, estrogens
Transection of C7 will lead to…?
Bradycardia due to cutting off the sympathetic plexus
Nausea and vomiting symptoms are mediated by what region of the brain?
Area Postrema
Bee sting allergy rxn is mediated by?
IgE antibodies
Pet bird gave women severe mitral regurgitation..what microbe is responsible?
Chlamydia psittaci..causes both atypical pneumonia and endocarditis
HIV patient with bilateral large white areas with perivascular exudates and hemorrhages. What is the patient CD4 count?
<200, around 50/mm cubed
Kawarshiokor is caused by?
Protein deficiency. Worse prognosis than Marasmus (which is total calorie deficiency)
Colchicine MOA
Blockage of polymerization of microtubules