High Yield Cancer Drug Associations from DIT

Question 1

Forms a complex between topoisomerase II and DNA

Answer 1

Etoposide, teniposide

Question 2

alyklates DNA, toxicity -> pulmonary fibrosis

Answer 2

Busulfan

Question 3

fragments DNA, toxicity -> pulmonary fibrosis

Answer 3

Bleomycin

Question 4

blocks purine synthesis, metabolized by xanthine oxidase

Answer 4

Azathioprine, 6 mercaptopurine (6MP), 6 thioguanine (6TG). 6TG can be given w/ allopurinol

Question 5

Cross links DNA, nephrotoxic, ototoxic

Answer 5

Cisplatin, carboplatin

Question 6

nitrogen mustard, alkylates DNA (electrophile that binds DNA)

Answer 6

Cyclophosphamide

Question 7

Folic acid analog that inhibits dihydrofolate reductase

Answer 7

Methotrexate

Question 8

prevents tubulin disassemply

Answer 8

Paclitaxol and other taxols

Question 9

intercalates DNA, produces oxygen free radicals, cardiotoxic

Answer 9

Doxorubicin and danorubicin

Question 10

DNA alkylating agents used in brain cancer

Answer 10

Nitrosureas (‘mustines)

Question 11

prevents tubulin assembly

Answer 11

Vincristine and vinblastine

Question 12

inhibits thymidylate synthase -> decreased nucleotide synthesis

Answer 12

5-fluorouracil (5-FU)

Question 13

SERM- blocks estrogen binding to ER+ cells

Answer 13

Tamoxifen, Raloxifene

Question 14

mechanism similar to antivirals acyclovir and foscarnet

Answer 14

Cytarabine

Question 15

mechanism similar to fluoroquinilones

Answer 15

Etoposide, Teniposide

Question 16

mechanism similar to trimethoprim

Answer 16

Methotrexate

Question 17

monoclonal antibody against HER-2 (erb-B2)

Answer 17

Trastuzumab

Question 18

free radical induced DNA strand breakage

Answer 18

Bleomycin, doxorubicin, daunorubicin

Question 19

inhibitor of PRPP sythetase

Answer 19

6MP, Azathioprine

Question 20

reversible with leucovorin

Answer 20

Methotrexate

Question 21

treatment for choriocarcinoma

Answer 21

Methotrexate, vincristine, vinblastine

Question 22

treatment for AML

Answer 22

cytarabine

Question 23

treatment for CML

Answer 23

Busulfan, imatinib

Question 24

prevents breast cancer

Answer 24

Tamoxifen, Raloxifene

Question 25

treatment for testicular cancer

Answer 25

Etoposide, bleomycin, cisplatin (eradicate ball cancer)

Question 26

applied topically for AKs and basal cell cancers

Answer 26

5-FU

Question 27

treatment for childhood tumors (Ewings sarcoma, rhabdomysarcoma, Wilm’s tumor)

Answer 27

Dactinomycin (kids ACT out)

Question 28

inhibits ribonucletide reductase

Answer 28

hydroxyurea

Question 29

SE of hemorrhagic cystitis

Answer 29

cyclophosphamide, ifosfamide

Question 30

Ab against Philadelphia chromosome

Answer 30

imatinib

Question 31

What are the potential side effects of prednisone use?

Answer 31

Cushing like symptoms, acne, psychosis, peptic ulcers, osteoporosis, insomnia, hypertension, immunosuppression, cataracts, hyperglycemia (KNOW ALL OF THESE!!)

Question 32

Monoclonal antibody against CD 20, treats follicular lymphoma and RA (w/ methotrexate)

Answer 32

RItuximab

Question 33

Small molecule inhibitor of the BRAF kinase w/ the V600E mutation (tx metastatic melanoma)

Answer 33

Vemurafenib

Question 34

Monoclonal Ab gaginst VEGF

Answer 34

Bevacizumab