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Hematology > High Yield Cancer Drug Associations from DIT > Flashcards

High Yield Cancer Drug Associations from DIT Flashcards

1
Q

Forms a complex between topoisomerase II and DNA

A

Etoposide, teniposide

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2
Q

alyklates DNA, toxicity -> pulmonary fibrosis

A

Busulfan

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3
Q

fragments DNA, toxicity -> pulmonary fibrosis

A

Bleomycin

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4
Q

blocks purine synthesis, metabolized by xanthine oxidase

A

Azathioprine, 6 mercaptopurine (6MP), 6 thioguanine (6TG). 6TG can be given w/ allopurinol

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5
Q

Cross links DNA, nephrotoxic, ototoxic

A

Cisplatin, carboplatin

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6
Q

nitrogen mustard, alkylates DNA (electrophile that binds DNA)

A

Cyclophosphamide

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7
Q

Folic acid analog that inhibits dihydrofolate reductase

A

Methotrexate

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8
Q

prevents tubulin disassemply

A

Paclitaxol and other taxols

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9
Q

intercalates DNA, produces oxygen free radicals, cardiotoxic

A

Doxorubicin and danorubicin

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10
Q

DNA alkylating agents used in brain cancer

A

Nitrosureas (‘mustines)

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11
Q

prevents tubulin assembly

A

Vincristine and vinblastine

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12
Q

inhibits thymidylate synthase -> decreased nucleotide synthesis

A

5-fluorouracil (5-FU)

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13
Q

SERM- blocks estrogen binding to ER+ cells

A

Tamoxifen, Raloxifene

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14
Q

mechanism similar to antivirals acyclovir and foscarnet

A

Cytarabine

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15
Q

mechanism similar to fluoroquinilones

A

Etoposide, Teniposide

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16
Q

mechanism similar to trimethoprim

A

Methotrexate

17
Q

monoclonal antibody against HER-2 (erb-B2)

A

Trastuzumab

18
Q

free radical induced DNA strand breakage

A

Bleomycin, doxorubicin, daunorubicin

19
Q

inhibitor of PRPP sythetase

A

6MP, Azathioprine

20
Q

reversible with leucovorin

A

Methotrexate

21
Q

treatment for choriocarcinoma

A

Methotrexate, vincristine, vinblastine

22
Q

treatment for AML

A

cytarabine

23
Q

treatment for CML

A

Busulfan, imatinib

24
Q

prevents breast cancer

A

Tamoxifen, Raloxifene

25
Q

treatment for testicular cancer

A

Etoposide, bleomycin, cisplatin (eradicate ball cancer)

26
Q

applied topically for AKs and basal cell cancers

A

5-FU

27
Q

treatment for childhood tumors (Ewings sarcoma, rhabdomysarcoma, Wilm’s tumor)

A

Dactinomycin (kids ACT out)

28
Q

inhibits ribonucletide reductase

A

hydroxyurea

29
Q

SE of hemorrhagic cystitis

A

cyclophosphamide, ifosfamide

30
Q

Ab against Philadelphia chromosome

A

imatinib

31
Q

What are the potential side effects of prednisone use?

A

Cushing like symptoms, acne, psychosis, peptic ulcers, osteoporosis, insomnia, hypertension, immunosuppression, cataracts, hyperglycemia (KNOW ALL OF THESE!!)

32
Q

Monoclonal antibody against CD 20, treats follicular lymphoma and RA (w/ methotrexate)

A

RItuximab

33
Q

Small molecule inhibitor of the BRAF kinase w/ the V600E mutation (tx metastatic melanoma)

A

Vemurafenib

34
Q

Monoclonal Ab gaginst VEGF

A

Bevacizumab

Hematology (1 decks)

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