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(J2) WBCs, Spleen, and Thymus > High Yield > Flashcards

High Yield Flashcards

1
Q

What is t(8:14) associated with?

A

Burkitt lymphoma

(worst lymphoma (8 letters) transormations (14 letters), Burkitt lymphoma is one of the fastest growing tumors)

MYC

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2
Q

What is t(9:22) associated with?

A

Chronic myelogenous leukemia

Philadelphia chromosome

BCR-ABL fusion product

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3
Q

What is t(15:17) associated with?

A

Acute promyelocytic leukemia (Acute myeloid leukemia subtye)

Retinoic receptor α (RARα)

Auer rods (Myeloperoxidase (MPO) crystals)

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4
Q

What is t(11;14) associated with?

A

Mantle cell lymphoma

cyclin-D1

G1 -> S transition

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5
Q

What is t(14;18) associated with?

A

follicular lymphoma

BCL-2

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6
Q

What is a “starry sky” appearance associated with?

A

Burkitt lymphoma

Macrophage “stars” eating necrotic cells with background of dense B cells “sky”

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7
Q

What is basophila associated with?

A

Chronic myeloid leukemia

basophils are rarely elevated, in CML, there is an over proliferation of all granulocytes, which includes basophils

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8
Q

What are Auer rods associated with?

A

Acute myeloid leukemia

Auer rods = aggregates of myeloperoxidase (MPO)

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9
Q

What are B signs?

A

S/x associated with B cell neoplasms

consists of generalized symptoms:

  • fever
  • weight loss
  • fatigue
  • pain
  • night sweats
  • pruritis
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10
Q

What are dacrocytes (“teardrop cells”) most associated with?

A

Primary myelofibrosis

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11
Q

What are smudge cells associated with?

A

CLL

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12
Q

What leukemia/lymphoma are CD5+ B cells associated with?

A

CLL

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13
Q

What leukemia/lymphoma is associated with a marrow fibrosis and a “dry tap”.

A

Hairy cell leukemia

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14
Q

What leukemia/lymphoma is associated with overexpression of Bcl-2?

A

follicular lymphoma

t(14;18)

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15
Q

What leukemia/lymphpoma is associated with CD15+ and CD30+ cells?

A

Hodgkin lymphoma

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16
Q

What leukemia/lymphoma is NF-κB activation associated with?

A

Hodgkin lymphoma

(frequently but not always through EBV)

17
Q

What type of lymphoma/leukemia is peroxidase associated with?

A

Myleoid differenitated cell types

18
Q

What type of lymphoma/leukemia is non-specific esterase associated with?

A

Monocytic differenitated cell types

19
Q

What type of lymphoma/leukemia is BCL-6 most associated with?

A

diffuse large B-cell lymphoma

20
Q

What type of lymphoma/leukemia is BRAF most associated with?

A

Hairy cell leukemia

(J2) WBCs, Spleen, and Thymus (12 decks)

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