High-Yield Flashcards by Jennifer Becker

Which Anti-cancer drug can cause nephrotoxicity & ototoxicity?

Cisplatin

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Which alkylating agent Tx brain cancer & is lipid soluble?

Carmustine

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Which HAART drug can cause peripheral neuropathy & fatal pancreatitis?

Didanosine

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Tx pregnant HIV+ females w/ ?

Zidovudine

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Which is the only HAART med affected by gastric pH & food in the stomach?

Didanosine

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Which HAART med is used to BOOST serum concentrations of other HAARTs?

Ritonavir

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Pharmacologic action of Methotrexate

inhibits B- & T-cells, bone marrow suppression, CCS for S, causes n/v, inhibition of dihydrofolate reductase

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Which drug binds to thymidylate synthetase?

Fluorouracil

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Which anticancer med is known to cause cardiomyopathy?

Daunorubicin & Doxorubicin

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Which anticancer med is often used to treat RA & SOT?

Cyclophosphamide & Methotrexate

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Which anticancer drug/s disrupt the mitotic spindle?

Vincristine & Vinblastine

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Which NRTIs have action against HBV

Lamivudine, Emtricitabine, Tenofovir

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Which anticancer drug binds to Topoisomerase II & DNA

Etoposide

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Which anticancer drug/s only have delayed toxicity?

Fluorouracil & Cytorabine

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Which anticancer drug promotes MT polymerization?

Paclitazel

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Which anticancer drug inhibits DNA pol?

Cytarabine

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Which anticancer drug causes Cushing’s Syndrome?

Prednisone & Dexamethasone

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Which anticancer drug actually has tumor promoting side effects?

Tamoxifen

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Which anticancer drug is used to treat Ckit GI stromal tumors?

Imatinib mesylate

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Zidovudine S/E

anemia, neutropenia

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Lamivudine S/E

Hepatitis flare if pt has HBV

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Abacavir S/E

HSN rxn - rash

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Emtricitabine S/E

hyper pigmentation of palms/soles; BEST tolerated NRTI

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Tenofovir S/E

renal toxicity

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Which HAART causes CNS S/E like dizziness, confusion, inability to concentrate?

Efavirenz

Which HAART causes neural tube defects?

Efavirenz

Which HAART causes circumoral numbness & peripheral parethesias?

Ritonavir

Which HAART causes nephrolithiasis?

Indinavir

Which HAART causes lipodystrophy?

Atazanavir (PI inhibitors)

Chloroquine & Hydrochloroquine S/E

retinal & corneal toxicity

Do not use Chloroquine & Hydrochloroquine in pts w/

psorasis or poyphyria

Which anti-helminthic drug can cause similar toxicity as aspirin OD?

Quinine & Quinidine gluconate

Which anti-helminthic drug can be used as a muscle relaxant?

Quinine & Quinidine gluconate

Do not use Quinine & Quinidine gluconate in pts w/

pregnant patients

Resistance to Chloroquine & Hydrochloroquine

efflux pump

Which antimalarial drug may cause permanent discoloration of teeth in neonates?

Doxycycline

Mefloquine S/E

aggravation of latent psychoses, Seizures

Doxycycline S/E

phototoxicity

Treatment for a tapeworm (Cestode)?

Praziquantel

Tx for C. difficile?

Metronidazole

Triple therapy for H. pylori

Metronidazole, Clarithromycin, Bismuth & PPI

Tx for B. fragilis?

Metronidazole

T. vaginalis Tx

Metronidazole

Metronidazole causes EtOH interactions bc it inhibits?

aldehyde dehydrogenase

Antimuscarinic anticancer drug

Paclitaxel

Albendazole S/E

hepatotoxicty & leukopenia

Prevention of nausea in cancer pts on chemotherapy

metoclopramide

Prednisone S/E

weight gain, obesity, osteoporosis, adrenal suppression, cushiness syndrome, hypernatremia, cataracts, peptic ulcers, infections

Tamoxifen S/E

visual disturbances, endometrial cancer

Most potent anti-inflammatory agent

Dexamethasone

Antiemetic use

prochlorperazine

Acute dystonia

muscle spasms, facial grimacing, torticollis, twitching

Tx of enuresis?

Imipramine

Clozapine, Olanzapine, Quetiapine, Ziprasidone MOA

D4 & 5-HT-2 antagonist

Risperidone MOA

D2 & 5-HT-2 antagonist

Tx of Neuropathic pain

Duloxetine

Aripiprazole MOA

agonist/antagonist at D2 & 5-HT-1

Tx for Parkinson's pt w/ psychosis

Clozapine

Nicotine Withdrawal/Dependence Tx

Buproprion

Nighttime depression Tx

Trazodone & Nefazodone

NMS

rigidity, hyperthermia, stupor (Ca2+ release from SR)

Tx of NMS

Bromocryptine & Dantrolene

Tx for bipolar pt w/ sick sinus syndrome or hypothyroidism?

valproic acid, carbamazepine

Lithium S/E

polydipsia, polyuria, hypothyroidism, arrhythmia, edema, tremor weight gain, teratogenic effects

Valproic acid S/E

hepatotoxicity

Least likely antidepressant to cause CV or seizure effects?

SSRIs

Greatest CNS stimulation

d-amphetamines

NSAID effect on Lithium?

decrease excretion

Na+ effect on Lithium?

low Na+ diet leads to Lithium retention

Which drug may causes orthostatic hypotension, but then cause HTN in crisis situations?

MAO-I (Phenelzine, Tranylcypromine)

MAO-I S/E

CNS Stimulation, orthostatic hypotension, liver damage, reduction in b-adrenergic receptors w/ long-term use, tyramine/sympathimimetic agents may cause HTN crisis