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Pharm Exam 8 > High-Yield > Flashcards

High-Yield Flashcards

1
Q

Which Anti-cancer drug can cause nephrotoxicity & ototoxicity?

A

Cisplatin

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2
Q

Which alkylating agent Tx brain cancer & is lipid soluble?

A

Carmustine

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3
Q

Which HAART drug can cause peripheral neuropathy & fatal pancreatitis?

A

Didanosine

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4
Q

Tx pregnant HIV+ females w/ ?

A

Zidovudine

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5
Q

Which is the only HAART med affected by gastric pH & food in the stomach?

A

Didanosine

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6
Q

Which HAART med is used to BOOST serum concentrations of other HAARTs?

A

Ritonavir

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7
Q

Pharmacologic action of Methotrexate

A

inhibits B- & T-cells, bone marrow suppression, CCS for S, causes n/v, inhibition of dihydrofolate reductase

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8
Q

Which drug binds to thymidylate synthetase?

A

Fluorouracil

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9
Q

Which anticancer med is known to cause cardiomyopathy?

A

Daunorubicin & Doxorubicin

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10
Q

Which anticancer med is often used to treat RA & SOT?

A

Cyclophosphamide & Methotrexate

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11
Q

Which anticancer drug/s disrupt the mitotic spindle?

A

Vincristine & Vinblastine

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12
Q

Which NRTIs have action against HBV

A

Lamivudine, Emtricitabine, Tenofovir

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13
Q

Which anticancer drug binds to Topoisomerase II & DNA

A

Etoposide

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14
Q

Which anticancer drug/s only have delayed toxicity?

A

Fluorouracil & Cytorabine

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15
Q

Which anticancer drug promotes MT polymerization?

A

Paclitazel

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16
Q

Which anticancer drug inhibits DNA pol?

A

Cytarabine

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17
Q

Which anticancer drug causes Cushing’s Syndrome?

A

Prednisone & Dexamethasone

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18
Q

Which anticancer drug actually has tumor promoting side effects?

A

Tamoxifen

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19
Q

Which anticancer drug is used to treat Ckit GI stromal tumors?

A

Imatinib mesylate

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20
Q

Zidovudine S/E

A

anemia, neutropenia

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21
Q

Lamivudine S/E

A

Hepatitis flare if pt has HBV

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22
Q

Abacavir S/E

A

HSN rxn - rash

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23
Q

Emtricitabine S/E

A

hyper pigmentation of palms/soles; BEST tolerated NRTI

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24
Q

Tenofovir S/E

A

renal toxicity

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25
Q

Which HAART causes CNS S/E like dizziness, confusion, inability to concentrate?

A

Efavirenz

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26
Q

Which HAART causes neural tube defects?

A

Efavirenz

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27
Q

Which HAART causes circumoral numbness & peripheral parethesias?

A

Ritonavir

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28
Q

Which HAART causes nephrolithiasis?

A

Indinavir

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29
Q

Which HAART causes lipodystrophy?

A

Atazanavir (PI inhibitors)

30
Q

Chloroquine & Hydrochloroquine S/E

A

retinal & corneal toxicity

31
Q

Do not use Chloroquine & Hydrochloroquine in pts w/

A

psorasis or poyphyria

32
Q

Which anti-helminthic drug can cause similar toxicity as aspirin OD?

A

Quinine & Quinidine gluconate

33
Q

Which anti-helminthic drug can be used as a muscle relaxant?

A

Quinine & Quinidine gluconate

34
Q

Do not use Quinine & Quinidine gluconate in pts w/

A

pregnant patients

35
Q

Resistance to Chloroquine & Hydrochloroquine

A

efflux pump

36
Q

Which antimalarial drug may cause permanent discoloration of teeth in neonates?

A

Doxycycline

37
Q

Mefloquine S/E

A

aggravation of latent psychoses, Seizures

38
Q

Doxycycline S/E

A

phototoxicity

39
Q

Treatment for a tapeworm (Cestode)?

A

Praziquantel

40
Q

Tx for C. difficile?

A

Metronidazole

41
Q

Triple therapy for H. pylori

A

Metronidazole, Clarithromycin, Bismuth & PPI

42
Q

Tx for B. fragilis?

A

Metronidazole

43
Q

T. vaginalis Tx

A

Metronidazole

44
Q

Metronidazole causes EtOH interactions bc it inhibits?

A

aldehyde dehydrogenase

45
Q

Antimuscarinic anticancer drug

A

Paclitaxel

46
Q

Albendazole S/E

A

hepatotoxicty & leukopenia

47
Q

Prevention of nausea in cancer pts on chemotherapy

A

metoclopramide

48
Q

Prednisone S/E

A

weight gain, obesity, osteoporosis, adrenal suppression, cushiness syndrome, hypernatremia, cataracts, peptic ulcers, infections

49
Q

Tamoxifen S/E

A

visual disturbances, endometrial cancer

50
Q

Most potent anti-inflammatory agent

A

Dexamethasone

51
Q

Antiemetic use

A

prochlorperazine

52
Q

Acute dystonia

A

muscle spasms, facial grimacing, torticollis, twitching

53
Q

Tx of enuresis?

A

Imipramine

54
Q

Clozapine, Olanzapine, Quetiapine, Ziprasidone MOA

A

D4 & 5-HT-2 antagonist

55
Q

Risperidone MOA

A

D2 & 5-HT-2 antagonist

56
Q

Tx of Neuropathic pain

A

Duloxetine

57
Q

Aripiprazole MOA

A

agonist/antagonist at D2 & 5-HT-1

58
Q

Tx for Parkinson’s pt w/ psychosis

A

Clozapine

59
Q

Nicotine Withdrawal/Dependence Tx

A

Buproprion

60
Q

Nighttime depression Tx

A

Trazodone & Nefazodone

61
Q

NMS

A

rigidity, hyperthermia, stupor (Ca2+ release from SR)

62
Q

Tx of NMS

A

Bromocryptine & Dantrolene

63
Q

Tx for bipolar pt w/ sick sinus syndrome or hypothyroidism?

A

valproic acid, carbamazepine

64
Q

Lithium S/E

A

polydipsia, polyuria, hypothyroidism, arrhythmia, edema, tremor weight gain, teratogenic effects

65
Q

Valproic acid S/E

A

hepatotoxicity

66
Q

Least likely antidepressant to cause CV or seizure effects?

A

SSRIs

67
Q

Greatest CNS stimulation

A

d-amphetamines

68
Q

NSAID effect on Lithium?

A

decrease excretion

69
Q

Na+ effect on Lithium?

A

low Na+ diet leads to Lithium retention

70
Q

Which drug may causes orthostatic hypotension, but then cause HTN in crisis situations?

A

MAO-I (Phenelzine, Tranylcypromine)

71
Q

MAO-I S/E

A

CNS Stimulation, orthostatic hypotension, liver damage, reduction in b-adrenergic receptors w/ long-term use, tyramine/sympathimimetic agents may cause HTN crisis

Pharm Exam 8 (3 decks)

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